Skip to main content
NCBI home page
Journal of Clinical Pathology logoLink to Journal of Clinical Pathology
. 1996 Jul;49(7):595–597. doi: 10.1136/jcp.49.7.595

B cell lymphoma of the thymus and salivary gland.

C Di Loreto 1, L Mariuzzi 1, A De Grassi 1, C A Beltrami 1
PMCID: PMC500579  PMID: 8813963

Abstract

A case of primary low grade B cell lymphoma of the salivary gland associated with a low grade B cell lymphoma of the thymus and involvement of the skin is reported. The lesions in the salivary gland and in the thymus showed the typical features of a lymphoma arising from the mucosa associated lymphoid tissue (MALT) and comprised lymphatic follicles, centrocyte-like (CCL) cells and lymphoepithelial lesions. Immunohistochemistry and Southern blot analysis supported the hypothesis that these lesions can originate from the same cellular clone. These findings confirm the occurrence of low grade B cell MALT lymphoma in the thymus and the possibility of spread of MALT lymphoma to other mucosal sites.

Full text

PDF
595

Images in this article

596Image
on p.596
596Image
on p.596

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Giannotti B., Santucci M. Skin-associated lymphoid tissue (SALT)-related B-cell lymphoma (primary cutaneous B-cell lymphoma). A concept and a clinicopathologic entity. Arch Dermatol. 1993 Mar;129(3):353–355. [PubMed] [Google Scholar]
  2. Hieter P. A., Hollis G. F., Korsmeyer S. J., Waldmann T. A., Leder P. Clustered arrangement of immunoglobulin lambda constant region genes in man. Nature. 1981 Dec 10;294(5841):536–540. doi: 10.1038/294536a0. [DOI] [PubMed] [Google Scholar]
  3. Hieter P. A., Max E. E., Seidman J. G., Maizel J. V., Jr, Leder P. Cloned human and mouse kappa immunoglobulin constant and J region genes conserve homology in functional segments. Cell. 1980 Nov;22(1 Pt 1):197–207. doi: 10.1016/0092-8674(80)90168-3. [DOI] [PubMed] [Google Scholar]
  4. Hyjek E., Smith W. J., Isaacson P. G. Primary B-cell lymphoma of salivary glands and its relationship to myoepithelial sialadenitis. Hum Pathol. 1988 Jul;19(7):766–776. doi: 10.1016/s0046-8177(88)80259-4. [DOI] [PubMed] [Google Scholar]
  5. Isaacson P. G., Chan J. K., Tang C., Addis B. J. Low-grade B-cell lymphoma of mucosa-associated lymphoid tissue arising in the thymus. A thymic lymphoma mimicking myoepithelial sialadenitis. Am J Surg Pathol. 1990 Apr;14(4):342–351. doi: 10.1097/00000478-199004000-00005. [DOI] [PubMed] [Google Scholar]
  6. Isaacson P. G., Spencer J. Malignant lymphoma of mucosa-associated lymphoid tissue. Histopathology. 1987 May;11(5):445–462. doi: 10.1111/j.1365-2559.1987.tb02654.x. [DOI] [PubMed] [Google Scholar]
  7. Li G., Hansmann M. L., Zwingers T., Lennert K. Primary lymphomas of the lung: morphological, immunohistochemical and clinical features. Histopathology. 1990 Jun;16(6):519–531. doi: 10.1111/j.1365-2559.1990.tb01157.x. [DOI] [PubMed] [Google Scholar]
  8. Norton A. J., Isaacson P. G. Detailed phenotypic analysis of B-cell lymphoma using a panel of antibodies reactive in routinely fixed wax-embedded tissue. Am J Pathol. 1987 Aug;128(2):225–240. [PMC free article] [PubMed] [Google Scholar]
  9. Takagi N., Nakamura S., Yamamoto K., Kunishima K., Takagi I., Suyama M., Shinoda M., Sugiura T., Oyama A., Suzuki H. Malignant lymphoma of mucosa-associated lymphoid tissue arising in the thymus of a patient with Sjögren's syndrome. A morphologic, phenotypic, and genotypic study. Cancer. 1992 Mar 15;69(6):1347–1355. doi: 10.1002/1097-0142(19920315)69:6<1347::aid-cncr2820690608>3.0.co;2-c. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Clinical Pathology are provided here courtesy of BMJ Publishing Group

RESOURCES