Abstract
Sclerosing lymphocytic lobulitis is an inflammatory disorder of the breast that is well recognised in women. It has only been reported previously in two men; two further men with the condition are described here. Both presented with a breast mass, and one was an insulin dependent diabetic. Biopsy specimens from both patients showed circumscribed perivascular and, to a lesser extent, periductal collections of B and T lymphocytes. Sclerosing lymphocytic lobulitis in the female breast shows predominantly perilobular inflammation. The predominantly perivascular distribution in men is consistent with the relative paucity of epithelium in the male breast. Interlobular fibrosis with epithelioid fibroblasts was also present.
Full text
PDF


Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Ashton M. A., Lefkowitz M., Tavassoli F. A. Epithelioid stromal cells in lymphocytic mastitis--a source of confusion with invasive carcinoma. Mod Pathol. 1994 Jan;7(1):49–54. [PubMed] [Google Scholar]
- Bártek J., Petrek M., Vojtesek B., Bártková J., Kovarík J., Rejthar A. HLA-DR antigens on differentiating human mammary gland epithelium and breast tumours. Br J Cancer. 1987 Dec;56(6):727–733. doi: 10.1038/bjc.1987.278. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Epenetos A. A., Bobrow L. G., Adams T. E., Collins C. M., Isaacson P. G., Bodmer W. F. A monoclonal antibody that detects HLA-D region antigen in routinely fixed, wax embedded sections of normal and neoplastic lymphoid tissues. J Clin Pathol. 1985 Jan;38(1):12–17. doi: 10.1136/jcp.38.1.12. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Giorno R. Mononuclear cells in malignant and benign human breast tissue. Arch Pathol Lab Med. 1983 Aug;107(8):415–417. [PubMed] [Google Scholar]
- Lammie G. A., Bobrow L. G., Staunton M. D., Levison D. A., Page G., Millis R. R. Sclerosing lymphocytic lobulitis of the breast--evidence for an autoimmune pathogenesis. Histopathology. 1991 Jul;19(1):13–20. doi: 10.1111/j.1365-2559.1991.tb00889.x. [DOI] [PubMed] [Google Scholar]
- Schwartz I. S., Strauchen J. A. Lymphocytic mastopathy. An autoimmune disease of the breast? Am J Clin Pathol. 1990 Jun;93(6):725–730. doi: 10.1093/ajcp/93.6.725. [DOI] [PubMed] [Google Scholar]
- Tomaszewski J. E., Brooks J. S., Hicks D., Livolsi V. A. Diabetic mastopathy: a distinctive clinicopathologic entity. Hum Pathol. 1992 Jul;23(7):780–786. doi: 10.1016/0046-8177(92)90348-7. [DOI] [PubMed] [Google Scholar]


