Table 2.
Association between SNPs and lung cancer cases with emphysema as compared to cases without emphysema, assuming dominant genetic model for each SNPa
| SNP | Nearest gene(s) | Chr | Minor allele | African Americans (N = 352) | Whites (N = 260) | P interaction c | Total sample (N = 612) | ||
|---|---|---|---|---|---|---|---|---|---|
| MARFb | OR (95%CI) | MARFb | OR (95%CI) | OR (95% CI) | |||||
| rs2256721 | CHIA | 1 | T | 0.201 | 0.73 (0.47, 1.15) | 0.265 | 0.70 (0.41, 1.18) | 0.973 | 0.72 (0.51, 1.02) |
| rs6680778 | CHD1L | 1 | T | 0.344 | 0.80 (0.51, 1.24) | 0.178 | 0.70 (0.40, 1.23) | 0.801 | 0.78 (0.55, 1.10) |
| rs13144371 | IBSP | 4 | A | 0.109 | 1.86 (1.06, 3.26) | 0.219 | 1.57 (0.90, 2.72) | 0.523 | 1.60 (1.09, 2.36) |
| rs140750089 | FLJ14186 | 4 | A | 0.255 | 0.71 (0.45, 1.12) | 0.247 | 1.06 (0.63, 1.79) | 0.223 | 0.84 (0.60, 1.18) |
| rs303061 | LINC00518 | 6 | C | 0.216 | 1.29 (0.82, 2.02) | 0.220 | 0.83 (0.49, 1.41) | 0.131 | 1.06 (0.76, 1.49) |
| rs9501572 | HLA-B | 6 | G | 0.369 | 0.75 (0.48, 1.17) | 0.274 | 0.91 (0.54, 1.54) | 0.471 | 0.80 (0.57, 1.12) |
| rs3130071 | SNORA38, PRRC2A | 6 | T | 0.026 | 0.77 (0.27, 2.16) | 0.125 | 1.39 (0.78, 2.46) | 0.335 | 1.23 (0.76, 2.00) |
| rs6944332 | PMS2CL | 7 | G | 0.475 | 1.49 (0.86, 2.60) | 0.905 | 1.22 (0.60, 2.47) | 0.640 | 1.30 (0.85, 2.00) |
| rs199638324 | FAM86B2 | 8 | T | 0.030 | 1.30 (0.42, 4.00) | 0.004 | No test | — | 1.16 (0.38, 3.57) |
| rs1288775 | GATM, GATM-AS1 | 15 | T | 0.205 | 1.22 (0.78, 1.91) | 0.692 | 1.56 (0.48, 5.08) | 0.611 | 1.34 (0.88, 2.03) |
Bold indicates significant result at α = 0.05.
aEach logistic regression model was adjusted for age, race (in total sample), sex, pack years education years and family history of lung cancer (yes/no).
bMinor allele relative frequencies estimated in controls only.
cTest of interaction effects on lung cancer subphenotype between SNP relative frequencies and race, in a logistic regression model adjusted for age, sex, pack years, education years and family history of lung cancer.