. 2016 Feb 26;139(4):1282–1294. doi: 10.1093/brain/aww010

Table 2.

Summary of DTI abnormalities of the main brain structures associated with delirium incidence and severity

	Delirium incidence				Delirium severity
	AD	FA	MD	RD	AD	FA	MD	RD
Cerebellum	ns	↓↓^L	↑*^,R	↑↑*^,R	↑^**^,B	ns	↑^**^,B	↑^**^,B
Cingulum	ns	↓↓ ^B	ns	ns	↑^B	↓↓ ^B	↑^B	↑↑^B
Corpus callosum	ns	↓↓	↑	↑↑	ns	↓↓	↑	↑↑
Hippocampus	ns	ns	ns	ns	↑↑^**^,L	ns	↑↑^**^,B	↑↑^**^,B
Internal capsule	ns	↓↓ ^L	ns	ns	ns	↓↓ ^L	↑↑^**^,B	↑↑*^,L
Occipital lobe	ns	ns	ns	ns	ns	↓↓ ^R	ns	↑↑^B
Parietal lobe	ns	ns	ns	ns	ns	↓↓ ^R	↑^R	↑^R
Temporal lobe	ns	ns	ns	ns	↑↑^**^,L	ns	↑↑^**^,B	↑↑^**^,B
Thalamus	ns	↓↓ ^L	ns	ns	↑↑*^,L	↓↓ ^B	↑↑^**^,B	↑↑^**^,B

↑ Indicates significant increase in DTI metric associated with delirium outcome, controlling for age, gender, and vascular comorbidity with P ≤ 0.05.

↑↑ Indicates significant increase in DTI metric associated with delirium outcome, controlling for age, gender, and vascular comorbidity with P ≤ 0.01.

↓ Indicates significant decrease in DTI metric associated with delirium outcome, controlling for age, gender, and vascular comorbidity with P ≤ 0.05.

↓↓Indicates significant decrease in DTI metric associated with delirium outcome, controlling for age, gender, and vascular comorbidity with P ≤ 0.01.

*Indicates significant association after adjustment for GCP in addition to age, gender, and vascular comorbidity with P ≤ 0.05.

^**Indicates significant association after adjustment for GCP in addition to age, gender, and vascular comorbidity with P ≤ 0.01.

ns =No significant association between DTI metric and delirium outcome, controlling for age, gender, and vascular comorbidity.

L/R Indicates unilateral (left/right) DTI abnormalities of the structure of interest (bilateral structures only).

B Indicates bilateral DTI abnormalities of the structure of interest (bilateral structures only). AD = axial diffusivity; MD = mean diffusivity; RD = radial diffusivity; FA = fractional anisotropy.