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. 1998 Mar;51(3):234–237. doi: 10.1136/jcp.51.3.234

Effect of kidney function and disease status on urinary tissue factor measurements.

B A Lwaleed 1, P S Bass 1, M E Rogerson 1, J L Francis 1, M Chisholm 1
PMCID: PMC500646  PMID: 9659267

Abstract

AIM: To investigate factors that influence urinary tissue factor (uTF) measurements: glomerular permeability and filtration, tubular function, haematuria, and urine bacterial growth. METHODS: uTF, protein creatinine index, glomerular filtration rate, retinol binding protein, N-acetyl-beta-D-glucosaminidase (NAG) and urinary haemoglobin (uHb) were measured in patients with hypertension, diabetes mellitus and nephrotic syndrome (n = 342), tubulo-interstitial disease (n = 50), and haematuria of uncertain cause (n = 50); measurements were also made in urine samples from healthy subjects for "simulated" haematuria (n = 6) and bacterial growth (n = 4) studies. RESULTS: There was a weak correlation of uTF with glomerular permeability and filtration (protein creatinine index and glomerular filtration rate) and with markers of tubular function (retinol binding protein and NAG). uTF concentrations were not affected by the presence of blood or bacteria in the urine sample. CONCLUSION: uTF concentrations are relatively stable. This is an important finding if the assay is to be used in clinical practice.

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Selected References

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  1. Adamson A. S., Francis J. L., Roath O. S., Witherow R. O., Snell M. E. Urinary tissue factor levels in transitional cell carcinoma of the bladder. J Urol. 1992 Aug;148(2 Pt 1):449–452. doi: 10.1016/s0022-5347(17)36626-0. [DOI] [PubMed] [Google Scholar]
  2. Bach R., Nemerson Y., Konigsberg W. Purification and characterization of bovine tissue factor. J Biol Chem. 1981 Aug 25;256(16):8324–8331. [PubMed] [Google Scholar]
  3. Bernard A. M., Moreau D., Lauwerys R. Comparison of retinol-binding protein and beta 2-microglobulin determination in urine for the early detection of tubular proteinuria. Clin Chim Acta. 1982 Nov 24;126(1):1–7. doi: 10.1016/0009-8981(82)90356-4. [DOI] [PubMed] [Google Scholar]
  4. Bröchner-Mortensen J., Rödbro P. Selection of routine method for determination of glomerular filtration rate in adult patients. Scand J Clin Lab Invest. 1976 Jan;36(1):35–43. doi: 10.1080/00365517609068016. [DOI] [PubMed] [Google Scholar]
  5. CALDWELL M. J., von KAULLA K., von KAULLA, SEEGERS W. H. Procoagulant material from human urine in prothrombin activation. Thromb Diath Haemorrh. 1963 Apr 15;9:53–61. [PubMed] [Google Scholar]
  6. Carty N., Taylor I., Roath O. S., el-Baruni K., Francis J. L. Urinary tissue factor activity in malignancy. Thromb Res. 1990 Feb 1;57(3):473–478. doi: 10.1016/0049-3848(90)90263-c. [DOI] [PubMed] [Google Scholar]
  7. Cockcroft D. W., Gault M. H. Prediction of creatinine clearance from serum creatinine. Nephron. 1976;16(1):31–41. doi: 10.1159/000180580. [DOI] [PubMed] [Google Scholar]
  8. Daugaard G., Rossing N., Rørth M. Effects of cisplatin on different measures of glomerular function in the human kidney with special emphasis on high-dose. Cancer Chemother Pharmacol. 1988;21(2):163–167. doi: 10.1007/BF00257365. [DOI] [PubMed] [Google Scholar]
  9. Drake T. A., Rodgers G. M., Sande M. A. Tissue factor is a major stimulus for vegetation formation in enterococcal endocarditis in rabbits. J Clin Invest. 1984 Jun;73(6):1750–1753. doi: 10.1172/JCI111383. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Folkman J. Tumor angiogenesis and tissue factor. Nat Med. 1996 Feb;2(2):167–168. doi: 10.1038/nm0296-167. [DOI] [PubMed] [Google Scholar]
  11. Francis J. L. Haemostasis and cancer. Med Lab Sci. 1989 Oct;46(4):331–346. [PubMed] [Google Scholar]
  12. Guha A., Bach R., Konigsberg W., Nemerson Y. Affinity purification of human tissue factor: interaction of factor VII and tissue factor in detergent micelles. Proc Natl Acad Sci U S A. 1986 Jan;83(2):299–302. doi: 10.1073/pnas.83.2.299. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Kurosawa S., Matsuda M., Aoki N. Urinary procoagulant behaves as tissue factor by promoting factor VIIa-catalyzed activation of factor X. Thromb Res. 1984 Mar 15;33(6):595–606. doi: 10.1016/0049-3848(84)90114-2. [DOI] [PubMed] [Google Scholar]
  14. Lwaleed B. A., Bass P. S., Chisholm M., Francis J. L. Urinary tissue factor in glomerulonephritis: a potential marker of glomerular injury? J Clin Pathol. 1997 Apr;50(4):336–340. doi: 10.1136/jcp.50.4.336. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Matsuda M., Aoki N., Kawaoi A. Localization of urinary procoagulant in the human kidney. Kidney Int. 1979 Jun;15(6):612–617. doi: 10.1038/ki.1979.80. [DOI] [PubMed] [Google Scholar]
  16. Matsumura T., Hutt M. P., Von Kaulla K. N. Urinary procoagulant excretion in experimental renal disease. Proc Soc Exp Biol Med. 1968 Jan;127(1):147–153. doi: 10.3181/00379727-127-32643. [DOI] [PubMed] [Google Scholar]
  17. Matsumura T., Hutt M. P., von Kaulla K. N. Urinary procoagulant excretion and its relation to kidney function. Nephron. 1970;7(2):165–177. doi: 10.1159/000179818. [DOI] [PubMed] [Google Scholar]
  18. Matsumura T., Von Kaulla K. N. Procoagulant content of human urine in health and disease. Am J Clin Pathol. 1968 Aug;50(2):198–210. doi: 10.1093/ajcp/50.2.198. [DOI] [PubMed] [Google Scholar]
  19. Nemerson Y., Bach R. Tissue factor revisited. Prog Hemost Thromb. 1982;6:237–261. [PubMed] [Google Scholar]
  20. Nemerson Y. The tissue factor pathway of blood coagulation. Semin Hematol. 1992 Jul;29(3):170–176. [PubMed] [Google Scholar]
  21. Orsonneau J. L., Douet P., Massoubre C., Lustenberger P., Bernard S. An improved pyrogallol red-molybdate method for determining total urinary protein. Clin Chem. 1989 Nov;35(11):2233–2236. [PubMed] [Google Scholar]
  22. Osterud B., Flaegstad T. Increased tissue thromboplastin activity in monocytes of patients with meningococcal infection: related to an unfavourable prognosis. Thromb Haemost. 1983 Feb 28;49(1):5–7. [PubMed] [Google Scholar]
  23. Osterud B., Rapaport S. I. Activation of factor IX by the reaction product of tissue factor and factor VII: additional pathway for initiating blood coagulation. Proc Natl Acad Sci U S A. 1977 Dec;74(12):5260–5264. doi: 10.1073/pnas.74.12.5260. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Rowe D. J., Anthony F., Polak A., Shaw K., Ward C. D., Watts G. F. Retinol binding protein as a small molecular weight marker of renal tubular function in diabetes mellitus. Ann Clin Biochem. 1987 Sep;24(Pt 5):477–482. doi: 10.1177/000456328702400509. [DOI] [PubMed] [Google Scholar]
  25. Twyman S. J., Rowe D. J. A sensitive radioimmunoassay for the determination of haemoglobin in urine. Ann Clin Biochem. 1995 Sep;32(Pt 5):506–508. doi: 10.1177/000456329503200513. [DOI] [PubMed] [Google Scholar]
  26. VON KAULLA K. N. Extraction and concentration of thromboplastic material from human urine. Proc Soc Exp Biol Med. 1956 Apr;91(4):543–545. doi: 10.3181/00379727-91-22321. [DOI] [PubMed] [Google Scholar]
  27. Waller D. G., Keast C. M., Fleming J. S., Ackery D. M. Measurement of glomerular filtration rate with technetium-99m DTPA: comparison of plasma clearance techniques. J Nucl Med. 1987 Mar;28(3):372–377. [PubMed] [Google Scholar]
  28. Watanabe N., Kamei S., Ohkubo A., Yamanaka M., Ohsawa S., Makino K., Tokuda K. Urinary protein as measured with a pyrogallol red-molybdate complex, manually and in a Hitachi 726 automated analyzer. Clin Chem. 1986 Aug;32(8):1551–1554. [PubMed] [Google Scholar]
  29. Wellwood J. M., Price R. G., Ellis B. G., Thompson A. E. A note on the practical aspects of the assay of N-acetyl-beta-glucosaminidase in human urine. Clin Chim Acta. 1976 May 17;69(1):85–91. doi: 10.1016/0009-8981(76)90475-7. [DOI] [PubMed] [Google Scholar]
  30. Wiggins R., Glatfelter A., Kshirsagar B., Beals T. Lipid microvesicles and their association with procoagulant activity in urine and glomeruli of rabbits with nephrotoxic nephritis. Lab Invest. 1987 Mar;56(3):264–272. [PubMed] [Google Scholar]
  31. Yuen C. T., Price R. G., Chattagoon L., Richardson A. C., Praill P. F. Colorimetric assays for N-acetyl-beta-D-glucosaminidase and beta-D-galactosidase in human urine using newly-developed omega-nitrostyryl substrates. Clin Chim Acta. 1982 Sep 15;124(2):195–204. doi: 10.1016/0009-8981(82)90387-4. [DOI] [PubMed] [Google Scholar]
  32. Zacharski L. R., Rosenstein R., Phillips P. G. Concanavalin A inhibition of tissue factor (thromboplastin) activity. Blood. 1974 Dec;44(6):783–787. [PubMed] [Google Scholar]

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