Abstract
A case of neurocytoma arising in the rostral pontine region of an 18 year old man is reported. The patient developed a right trochlear nerve palsy and was shown to have a well circumscribed, contrast enhancing mass on magnetic resonance imaging. The tumour was characterised histologically by a uniform population of medium sized round nuclei and slightly eosinophilic cytoplasm or occasional perinuclear halos, with delicate branching capillaries, patches of fibrillary matrix, and occasional perivascular pseudorosettes. Immunohistochemical studies demonstrated strong reactivity for synaptophysin in the fibrillary processes and cytoplasm of tumour cells. The present tumour is an exceptional case of neurocytoma arising in the pons.
Full text
PDFImages in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Bruner J. M. Oligodendroglioma: diagnosis and prognosis. Semin Diagn Pathol. 1987 Aug;4(3):251–261. [PubMed] [Google Scholar]
- Coca S., Moreno M., Martos J. A., Rodriguez J., Barcena A., Vaquero J. Neurocytoma of spinal cord. Acta Neuropathol. 1994;87(5):537–540. doi: 10.1007/BF00294182. [DOI] [PubMed] [Google Scholar]
- Ellison D. W., Zygmunt S. C., Weller R. O. Neurocytoma/lipoma (neurolipocytoma) of the cerebellum. Neuropathol Appl Neurobiol. 1993 Feb;19(1):95–98. doi: 10.1111/j.1365-2990.1993.tb00410.x. [DOI] [PubMed] [Google Scholar]
- Gould V. E., Wiedenmann B., Lee I., Schwechheimer K., Dockhorn-Dworniczak B., Radosevich J. A., Moll R., Franke W. W. Synaptophysin expression in neuroendocrine neoplasms as determined by immunocytochemistry. Am J Pathol. 1987 Feb;126(2):243–257. [PMC free article] [PubMed] [Google Scholar]
- Hassoun J., Söylemezoglu F., Gambarelli D., Figarella-Branger D., von Ammon K., Kleihues P. Central neurocytoma: a synopsis of clinical and histological features. Brain Pathol. 1993 Jul;3(3):297–306. doi: 10.1111/j.1750-3639.1993.tb00756.x. [DOI] [PubMed] [Google Scholar]
- Louis D. N., Swearingen B., Linggood R. M., Dickersin G. R., Kretschmar C., Bhan A. K., Hedley-Whyte E. T. Central nervous system neurocytoma and neuroblastoma in adults--report of eight cases. J Neurooncol. 1990 Dec;9(3):231–238. doi: 10.1007/BF02341154. [DOI] [PubMed] [Google Scholar]
- Miller D. C., Koslow M., Budzilovich G. N., Burstein D. E. Synaptophysin: a sensitive and specific marker for ganglion cells in central nervous system neoplasms. Hum Pathol. 1990 Jan;21(1):93–98. doi: 10.1016/0046-8177(90)90080-o. [DOI] [PubMed] [Google Scholar]
- Tatter S. B., Borges L. F., Louis D. N. Central neurocytomas of the cervical spinal cord. Report of two cases. J Neurosurg. 1994 Aug;81(2):288–293. doi: 10.3171/jns.1994.81.2.0288. [DOI] [PubMed] [Google Scholar]
- von Deimling A., Janzer R., Kleihues P., Wiestler O. D. Patterns of differentiation in central neurocytoma. An immunohistochemical study of eleven biopsies. Acta Neuropathol. 1990;79(5):473–479. doi: 10.1007/BF00296105. [DOI] [PubMed] [Google Scholar]
- von Deimling A., Kleihues P., Saremaslani P., Yasargil M. G., Spoerri O., Südhof T. C., Wiestler O. D. Histogenesis and differentiation potential of central neurocytomas. Lab Invest. 1991 Apr;64(4):585–591. [PubMed] [Google Scholar]