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. 1996 Oct;49(10):821–823. doi: 10.1136/jcp.49.10.821

Mycobacterium kansasii: its presentation, treatment and outcome in HIV infected patients.

G Rooney 1, M R Nelson 1, B Gazzard 1
PMCID: PMC500776  PMID: 8943748

Abstract

AIM: To report the clinical significance and treatment of Mycobacterium kansasii infection in the context of HIV disease. DESIGN/METHODS: Retrospective case review of all isolates of M kansasii until June 1994. RESULTS: Ten cases of M kansasii were isolated. All but one patient with this infection had clinical symptoms compatible with generalised infection. The majority had chest infections with the organism isolated on induced sputum but not routine sputum. All isolates were sensitive to ethambutol and nine of 10 to rifampicin. All isolates were resistant to isoniazid and pyrazinamide. CONCLUSION: M kansasii is a pathogen in HIV infected patients and should be treated when isolated. Treatment should be with rifampicin and ethambutol but not isoniazid, as has been recommended previously.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ahn C. H., McLarty J. W., Ahn S. S., Ahn S. I., Hurst G. A. Diagnostic criteria for pulmonary disease caused by Mycobacterium kansasii and Mycobacterium intracellulare. Am Rev Respir Dis. 1982 Apr;125(4):388–391. doi: 10.1164/arrd.1982.125.4.388. [DOI] [PubMed] [Google Scholar]
  2. Ahn C. H., Wallace R. J., Jr, Steele L. C., Murphy D. T. Sulfonamide-containing regimens for disease caused by rifampin-resistant Mycobacterium kansasii. Am Rev Respir Dis. 1987 Jan;135(1):10–16. doi: 10.1164/arrd.1987.135.1.10. [DOI] [PubMed] [Google Scholar]
  3. Bamberger D. M., Driks M. R., Gupta M. R., O'Connor M. C., Jost P. M., Neihart R. E., McKinsey D. S., Moore L. A. Mycobacterium kansasii among patients infected with human immunodeficiency virus in Kansas City. Kansas City AIDS Research Consortium. Clin Infect Dis. 1994 Mar;18(3):395–400. doi: 10.1093/clinids/18.3.395. [DOI] [PubMed] [Google Scholar]
  4. Carpenter J. L., Parks J. M. Mycobacterium kansasii infections in patients positive for human immunodeficiency virus. Rev Infect Dis. 1991 Sep-Oct;13(5):789–796. doi: 10.1093/clinids/13.5.789. [DOI] [PubMed] [Google Scholar]
  5. Chin D. P., Hopewell P. C., Yajko D. M., Vittinghoff E., Horsburgh C. R., Jr, Hadley W. K., Stone E. N., Nassos P. S., Ostroff S. M., Jacobson M. A. Mycobacterium avium complex in the respiratory or gastrointestinal tract and the risk of M. avium complex bacteremia in patients with human immunodeficiency virus infection. J Infect Dis. 1994 Feb;169(2):289–295. doi: 10.1093/infdis/169.2.289. [DOI] [PubMed] [Google Scholar]
  6. Engstrom P. F., Dewey G. C., Barrett O. N., Jr Disseminated Mycobacterium kansasii infection: successful treatment of a patient with pancytopenia. Am J Med. 1972 Apr;52(4):533–537. doi: 10.1016/0002-9343(72)90044-7. [DOI] [PubMed] [Google Scholar]
  7. Hawkins C. C., Gold J. W., Whimbey E., Kiehn T. E., Brannon P., Cammarata R., Brown A. E., Armstrong D. Mycobacterium avium complex infections in patients with the acquired immunodeficiency syndrome. Ann Intern Med. 1986 Aug;105(2):184–188. doi: 10.7326/0003-4819-105-2-184. [DOI] [PubMed] [Google Scholar]
  8. Horsburgh C. R., Jr, Selik R. M. The epidemiology of disseminated nontuberculous mycobacterial infection in the acquired immunodeficiency syndrome (AIDS). Am Rev Respir Dis. 1989 Jan;139(1):4–7. doi: 10.1164/ajrccm/139.1.4. [DOI] [PubMed] [Google Scholar]
  9. Levine B., Chaisson R. E. Mycobacterium kansasii: a cause of treatable pulmonary disease associated with advanced human immunodeficiency virus (HIV) infection. Ann Intern Med. 1991 May 15;114(10):861–868. doi: 10.7326/0003-4819-114-10-861. [DOI] [PubMed] [Google Scholar]
  10. Schraufnagel D. E., Leech J. A., Pollak B. Mycobacterium kansasii: colonization and disease. Br J Dis Chest. 1986 Apr;80(2):131–137. doi: 10.1016/0007-0971(86)90033-1. [DOI] [PubMed] [Google Scholar]
  11. Selik R. M., Starcher E. T., Curran J. W. Opportunistic diseases reported in AIDS patients: frequencies, associations, and trends. AIDS. 1987 Sep;1(3):175–182. [PubMed] [Google Scholar]
  12. Sherer R., Sable R., Sonnenberg M., Cooper S., Spencer P., Schwimmer S., Kocka F., Muthuswamy P., Kallick C. Disseminated infection with Mycobacterium kansasii in the acquired immunodeficiency syndrome. Ann Intern Med. 1986 Nov;105(5):710–712. doi: 10.7326/0003-4819-105-5-710. [DOI] [PubMed] [Google Scholar]
  13. Valainis G. T., Cardona L. M., Greer D. L. The spectrum of Mycobacterium kansasii disease associated with HIV-1 infected patients. J Acquir Immune Defic Syndr. 1991;4(5):516–520. [PubMed] [Google Scholar]
  14. Vincké G., Yegers O., Vanachter H., Jenkins P. A., Butzler J. P. Rapid susceptibility testing of Mycobacterium tuberculosis by a radiometric technique. J Antimicrob Chemother. 1982 Oct;10(4):351–354. doi: 10.1093/jac/10.4.351. [DOI] [PubMed] [Google Scholar]
  15. Wolinsky E. When is an infection disease? Rev Infect Dis. 1981 Sep-Oct;3(5):1025–1027. doi: 10.1093/clinids/3.5.1025. [DOI] [PubMed] [Google Scholar]

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