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. 1996 Oct;49(10):836–838. doi: 10.1136/jcp.49.10.836

Hepatitis C and bile duct loss.

R D Goldin 1, N K Patel 1, H C Thomas 1
PMCID: PMC500780  PMID: 8943752

Abstract

AIM: To assess whether bile duct loss is associated with the bile duct damage induced by chronic hepatitis C. METHODS: Sections were examined from 171 liver biopsy specimens from patients with chronic hepatitis C, 98 biopsy specimens from patients with chronic hepatitis B, 25 postmortem specimens from patients with no evidence of liver disease, and 23 patients who underwent protocol liver biopsy at the time of cholecystectomy. RESULTS: The bile duct:portal tract ratio for the hepatitis C group was 0.89, for the hepatitis B group was 0.93 and for the two control groups was 0.96 and 0.90, respectively. The ratio was lower in the hepatitis C group than in the other three. In no case of chronic hepatitis C was the ratio less than 0.60. In the hepatitis C group greater bile duct loss was seen in cirrhotic patients. CONCLUSIONS: Hepatitis C is associated with bile duct loss and this was related to the stage of the disease. However, in the cases studied this did not reach what is generally considered to be significant (that is, greater than 50% of portal tracts lacking bile ducts). This does not preclude a contributory effect of hepatitis C to bile duct loss in the presence of other risk factors, especially in liver transplant recipients.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bach N., Thung S. N., Schaffner F. The histological features of chronic hepatitis C and autoimmune chronic hepatitis: a comparative analysis. Hepatology. 1992 Apr;15(4):572–577. doi: 10.1002/hep.1840150403. [DOI] [PubMed] [Google Scholar]
  2. Bruguera M., Llach J., Rodés J. Nonsyndromic paucity of intrahepatic bile ducts in infancy and idiopathic ductopenia in adulthood: the same syndrome? Hepatology. 1992 May;15(5):830–834. doi: 10.1002/hep.1840150514. [DOI] [PubMed] [Google Scholar]
  3. Dousset B., Conti F., Houssin D., Calmus Y. Acute vanishing bile duct syndrome after interferon therapy for recurrent HCV infection in liver-transplant recipients. N Engl J Med. 1994 Apr 21;330(16):1160–1161. doi: 10.1056/NEJM199404213301618. [DOI] [PubMed] [Google Scholar]
  4. Farges O., Bismuth H., Sebagh M., Reynes M. Granulomatous destruction of bile ducts after liver transplantation: primary biliary cirrhosis recurrence or hepatitis C virus infection? Hepatology. 1995 Jun;21(6):1765–1767. [PubMed] [Google Scholar]
  5. Finegold M. J., Carpenter R. J. Obliterative cholangitis due to cytomegalovirus: a possible precursor of paucity of intrahepatic bile ducts. Hum Pathol. 1982 Jul;13(7):662–665. doi: 10.1016/s0046-8177(82)80011-7. [DOI] [PubMed] [Google Scholar]
  6. Hoffmann R. M., Günther C., Diepolder H. M., Zachoval R., Eissner H. J., Forst H., Anthuber M., Paumgartner G., Pape G. R. Hepatitis C virus infection as a possible risk factor for ductopenic rejection (vanishing bile duct syndrome) after liver transplantation. Transpl Int. 1995;8(5):353–359. doi: 10.1007/BF00337166. [DOI] [PubMed] [Google Scholar]
  7. Kaji K., Nakanuma Y., Sasaki M., Unoura M., Kobayashi K., Nonomura A., Tsuneyama K., Van de Water J., Gershwin M. E. Hepatitic bile duct injuries in chronic hepatitis C: histopathologic and immunohistochemical studies. Mod Pathol. 1994 Dec;7(9):937–945. [PubMed] [Google Scholar]
  8. Lefkowitch J. H., Schiff E. R., Davis G. L., Perrillo R. P., Lindsay K., Bodenheimer H. C., Jr, Balart L. A., Ortego T. J., Payne J., Dienstag J. L. Pathological diagnosis of chronic hepatitis C: a multicenter comparative study with chronic hepatitis B. The Hepatitis Interventional Therapy Group. Gastroenterology. 1993 Feb;104(2):595–603. doi: 10.1016/0016-5085(93)90432-c. [DOI] [PubMed] [Google Scholar]
  9. Ludwig J., Wiesner R. H., Batts K. P., Perkins J. D., Krom R. A. The acute vanishing bile duct syndrome (acute irreversible rejection) after orthotopic liver transplantation. Hepatology. 1987 May-Jun;7(3):476–483. doi: 10.1002/hep.1840070311. [DOI] [PubMed] [Google Scholar]
  10. Ludwig J., Wiesner R. H., LaRusso N. F. Idiopathic adulthood ductopenia. A cause of chronic cholestatic liver disease and biliary cirrhosis. J Hepatol. 1988 Oct;7(2):193–199. doi: 10.1016/s0168-8278(88)80482-3. [DOI] [PubMed] [Google Scholar]
  11. Nakanuma Y., Ohta G. Histometric and serial section observations of the intrahepatic bile ducts in primary biliary cirrhosis. Gastroenterology. 1979 Jun;76(6):1326–1332. [PubMed] [Google Scholar]
  12. Poulsen H., Christoffersen P. Abnormal bile duct epithelium in liver biopsies with histological signs of viral hepatitis. Acta Pathol Microbiol Scand. 1969;76(3):383–390. doi: 10.1111/j.1699-0463.1969.tb03269.x. [DOI] [PubMed] [Google Scholar]
  13. Scheuer P. J., Ashrafzadeh P., Sherlock S., Brown D., Dusheiko G. M. The pathology of hepatitis C. Hepatology. 1992 Apr;15(4):567–571. doi: 10.1002/hep.1840150402. [DOI] [PubMed] [Google Scholar]
  14. Zafrani E. S., Metreau J. M., Douvin C., Larrey D., Massari R., Reynes M., Doffoel M., Benhamou J. P., Dhumeaux D. Idiopathic biliary ductopenia in adults: a report of five cases. Gastroenterology. 1990 Dec;99(6):1823–1828. doi: 10.1016/0016-5085(90)90494-l. [DOI] [PubMed] [Google Scholar]

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