Figure 3. Transient manifestation of infection in the murine host following systemic inoculation with E. coli probiotics.

The host phenotype was evaluated in tumor bearing mice in response to infection with Symbioflor-2, EcN or SL7207. A. Development of host body weight over the course of systemic infection. B. Phenotypic appearance of wild-type mice upon infection. SL7207 infection causes fatigue and a disrupted fur coat, while probiotic infection does not cause observable manifestations. Representative images from 3 dpi are displayed. C. Progression in spleen weight of infected mice. D. Dose-response in host body weight with Symbioflor-2 infection. 1-, 10-, and 100- fold inoculum signify an infection dose of 5×10⁶, 5×10⁷ and 5×10⁸, respectively. N= 5-8. Mean ± SEM.