Table 2. Univariate and Multivariate Cox regression analysis of the association of various clinicopathological features with progression-free survival in training cohort.
| Feature | Univariate | Multivariate | ||
|---|---|---|---|---|
| Hazard ratio (95% CI) | P | Hazard ratio (95% CI) | P | |
| Age (y) ≥ 45 vs < 45 | 1.213 (0.782–1.883) | 0.388 | ||
| Gender F VSM | 0.781 (0.109–5.613) | 0.806 | ||
| Smoking status Present vs Absent | 0.967 (0.498–1.876) | 0.921 | ||
| Drinking status Present vs Absent | 0.760 (0.478–1.208) | 0.245 | ||
| Pathological differentiation | 0.023 | |||
| Highly | 1.000 | |||
| Moderately | 1.767 (1.071–2.914) | 0.026 | ||
| Poorly | 2.253 (1.187–4.276) | 0.013 | ||
| Site Non-glottic va Glottic | 0.641 (0.412–0.995) | 0.047 | ||
| T stage | < 0.001 | |||
| T1+T2 | 1.000 | |||
| T3 | 2.415 (1.427–4.087) | 0.001 | ||
| T4 | 2.989 (1.744–5.125) | < 0.001 | ||
| N stage | < 0.001 | < 0.001 | ||
| N0 | 1.000 | 1.000 | ||
| N1 | 2.044 (1.163–3.592) | 0.013 | 1.961 (1.115–3.451) | < 0.001 |
| N2 | 3.862 (2.129–7.007) | < 0.001 | 3.027 (1.659–5.522) | 0.019 |
| CISd2 High vs Low | 3.761 (2.280–6.203) | < 0.001 | 3.318 (2.030–5.425) | < 0.001 |
Abbreviations: SCC, laryngeal Squamous cell carcinoma (SCC); H, Highly differentiated; M, Moderately differentiated; P, Poorly differentiated; Non-Glottic, Supraglottic and Subglottic; Comprehensive, Surgery and chemotherapy or Surgery and radiotherapy; CISD2, CDGSH iron sulfur domain2.