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. 1996 Nov;49(11):950–951. doi: 10.1136/jcp.49.11.950

Malignant melanoma showing smooth muscle differentiation.

S S Banerjee 1, P W Bishop 1, C M Nicholson 1, B P Eyden 1
PMCID: PMC500840  PMID: 8944620

Abstract

A unique case of a metastatic non-desmoplastic sarcomatoid malignant melanoma in an axillary lymph node showing smooth muscle differentiation in a 54 year old woman is described. The tumour cells exhibited alpha-smooth muscle actin, HHF-35 and desmin positivity but were negative for S100 protein and HMB-45. Ultrastructural examination revealed smooth muscle phenotype and there was no evidence of myofibroblastic differentiation, a feature described previously in desmoplastic melanomas.

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Selected References

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