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. 2016 Mar 14;7(16):22791–22806. doi: 10.18632/oncotarget.8061

Figure 6. SIRT1 is a direct target of miR-449a in ERG-associated LnTE3 cells.

Figure 6

The miR-449a target 3′-UTR SIRT1 sequences as well as that of the mutated-derivative are indicated. Luciferase reporter assays were performed in ERG-inducible LnTE3 cells transfected with pMIR-Report vectors, either controls or those containing SIRT1 3′-UTR target sequences of miR-449a (both wildtype [WT] and mutant [mt]), in the presence or absence of pre-miR-449a. The data reflect averages of at least three independent experiments (* indicates p<0.05, ** indicates p>0.05).