On withdrawal day 4 after chronic vehicle or METH treatment (1 mg/Kg, sc, once a day for 7 days) mice received acute modafinil and 1 hr later performed a 10 min Novelty session in which they were allowed to explore two equal novel objects and euthanized immediately. Control mice were placed in the arena in the absence of objects and the same procedure was performed. A) Modafinil 30 mg/Kg, B) Modafinil 90 mg/Kg. Locomotion was analyzed with Ethovision XT 7.0 (Leesburg, Virginia). Two way ANOVA - Bonferroni. Values indicate the mean ± SEM (N=4– 9), different letters: p<0.05, *: different from METH-MOD control.