DDT and sCD74 serum levels were compared between surviving burn patients, non-surviving burn patients, and healthy controls. We further compared the levels between patients who died before 120 hours (patient 6, 16, 19) and patients who died between 120 hours and 10 days (“non-survivors (>5 days)”). A On admission, serum levels of DDT are significantly increased in non-survivors when compared to survivors and healthy controls. The DDT serum levels of survivors also are significantly higher when compared to controls. After a temporary decrease, DDT levels again increase in non-survivors. In survivors, DDT serum levels remain low with no statistical difference to healthy controls. B Patients 6, 16, and 19 who died within 5 days after admission show a rapid increase pre mortem when compared to patients who died after 5 days (“non-survivors (>5 days)”). C Serum levels of sCD74 are comparable in the early stage after burn injury but increase in non-survivors after 24 hours. Serum CD74 levels of survivors are slightly higher than healthy controls (statistically not significant). D Except for patient 6, patients who died within 5 days after admission (patients 16, 19) show higher levels of sCD74 when compared to patients who died after 5 days (“non-survivors (>5 days)”). Significant difference between non-survivors and survivors: ** p <0.01, *** p <0.001. Significant difference between non-survivors and healthy control: ## p <0.01, ### p <0.001. Significant difference between non-survivors and healthy control/survivor and healthy control: §§§ p <0.001. Data represent mean ± SEM