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. 1999 Mar;52(3):234–236. doi: 10.1136/jcp.52.3.234

Telomerase expression in intracranial tumours: prognostic potential for malignant gliomas and meningiomas.

M L Falchetti 1, R Pallini 1, L M Larocca 1, R Verna 1, E D'Ambrosio 1
PMCID: PMC501091  PMID: 10450187

Abstract

AIM: To evaluate the diagnostic value of telomerase expression in intracranial tumours. METHODS: 98 surgical specimens from different neoplasms were analysed by the telomeric repeat amplification protocol (TRAP) and the presence of telomerase compared with the histological diagnosis and the proliferation index. RESULTS: A high degree of positivity for telomerase activity was found in glioblastomas and atypical/anaplastic meningiomas. Telomerase activity was poorly detected in anaplastic astrocytomas. CONCLUSIONS: The TRAP assay seems to be a valuable index for identifying meningeal tumours with aggressive behaviour.

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Selected References

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