Dr. Gaetano Santulli is a physician scientist (cardiologist) working at Columbia University Medical Center in New York (NY). He earned his MD and PhD from the University of Naples “Federico II”, followed by a postdoctoral fellowship at Columbia University. He has expertise in both clinical and basic research. His research interests include heart failure [1-3], diabetes mellitus [4, 5], adrenergic signaling [1, 6], intracellular calcium release [7], mitochondrial function [4], microRNA [8], angiogenesis [9], coronary heart disease [10], hypertension [11-13], aging [5, 14-17], atrial fibrillation [18, 19], atherosclerosis [20], and cardiac resynchronization therapy [21-23]. He is currently funded by the National Institutes of Health. He is included among the Top Italian Scientists (VIA Academy). He is the author of several medical books, member of esteemed international associations, and associate editor of numerous prestigious scientific journals.
REFERENCES
- 1.Santulli G. beta-Blockers in diabetic patients with heart failure. JAMA Intern. Med. 2015;175:657. doi: 10.1001/jamainternmed.2014.8009. [DOI] [PubMed] [Google Scholar]
- 2.Santulli G., Xie W., Reiken S.R., Marks A.R. Mitochondrial calcium overload is a key determinant in heart failure. Proc. Natl. Acad. Sci. USA. 2015;112:11389–11394. doi: 10.1073/pnas.1513047112. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 3.Sorriento D., Santulli G., Franco A., et al. Integrating GRK2 and NFkappaB in the Pathophysiology of Cardiac Hypertrophy. J. Cardiovasc. Transl. Res. 2015;8:493–502. doi: 10.1007/s12265-015-9646-0. [DOI] [PubMed] [Google Scholar]
- 4.Santulli G., Pagano G., Sardu C., et al. Calcium release channel RyR2 regulates insulin release and glucose homeostasis. J. Clin. Invest. 2015;125:1968–1978. doi: 10.1172/JCI79273. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 5.Santulli G., Lombardi A., Sorriento D., et al. Age-related impairment in insulin release: the essential role of beta(2)-adrenergic receptor. Diabetes. 2012;61:692–701. doi: 10.2337/db11-1027. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 6.Santulli G. Adrenal signaling in heart failure: something more than a distant ship's smoke on the horizon. Hypertension. 2014;63:215–216. doi: 10.1161/HYPERTENSIONAHA.113.02382. [DOI] [PubMed] [Google Scholar]
- 7.Santulli G., Marks A.R. Essential roles of intracellular calcium release channels in muscle, brain, metabolism, and aging. Curr. Mol. Pharmacol. 2015;8:206–222. doi: 10.2174/1874467208666150507105105. [DOI] [PubMed] [Google Scholar]
- 8.Santulli G., Wronska A., Uryu K., et al. A selective microRNA-based strategy inhibits restenosis while preserving endothelial function. J. Clin. Invest. 2014;124:4102–4114. doi: 10.1172/JCI76069. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 9.Santulli G. Angiopoietin-like proteins: a comprehensive look. Front. Endocrinol. 2014;5:4. doi: 10.3389/fendo.2014.00004. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 10.Santulli G. Coronary heart disease risk factors and mortality. JAMA. 2012;307:1137. doi: 10.1001/jama.2012.323. [DOI] [PubMed] [Google Scholar]
- 11.Santulli G., Trimarco B., Iaccarino G. G-protein-coupled receptor kinase 2 and hypertension: molecular insights and pathophysiological mechanisms. High Blood Press. Cardiovasc. Prev. 2013;20:5–12. doi: 10.1007/s40292-013-0001-8. [DOI] [PubMed] [Google Scholar]
- 12.Santulli G., Cipolletta E., Sorriento D., et al. CaMK4 Gene Deletion Induces Hypertension. J. Am. Heart Assoc. 2012;1:e001081. doi: 10.1161/JAHA.112.001081. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 13.Yuan Q., Yang J., Santulli G., et al. Maintenance of normal blood pressure is dependent on IP3R1-mediated regulation of eNOS. Proc. Natl. Acad. Sci. USA. doi: 10.1073/pnas.1608859113. In press. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 14.Santulli G., Borras C., Bousquet J., et al. Models for preclinical studies in aging-related disorders: One is not for all. Transl. Med. UniSa. 2015;13:4–12. [PMC free article] [PubMed] [Google Scholar]
- 15.Santulli G., Ciccarelli M., Trimarco B., Iaccarino G. Physical activity ameliorates cardiovascular health in elderly subjects: the functional role of the beta adrenergic system. Front. Physiol. 2013;4:209. doi: 10.3389/fphys.2013.00209. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 16.Umanskaya A., Santulli G., Xie W., Andersson D.C., Reiken S.R., Marks A.R. Genetically enhancing mitochondrial antioxidant activity improves muscle function in aging. Proc. Natl. Acad. Sci. USA. 2014;111:15250–15255. doi: 10.1073/pnas.1412754111. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 17.Yuan Q., Chen Z., Santulli G., et al. Functional Role of Calstabin2 in Age-related Cardiac Alterations. Sci. Rep. 2014;4:7425. doi: 10.1038/srep07425. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 18.Santulli G., Iaccarino G., De Luca N., Trimarco B., Condorelli G. Atrial fibrillation and microRNAs. Front. Physiol. 2014;5:15. doi: 10.3389/fphys.2014.00015. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 19.Xie W., Santulli G., Reiken S.R., et al. Mitochondrial oxidative stress promotes atrial fibrillation. Sci. Rep. 2015;5:11427. doi: 10.1038/srep11427. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 20.Novak J., Olejnickova V., Tkacova N., Santulli G. Mechanistic Role of MicroRNAs in Coupling Lipid Metabolism and Atherosclerosis. Adv. Exp. Med. Biol. 2015;887:79–100. doi: 10.1007/978-3-319-22380-3_5. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 21.Sardu C., Marfella R., Santulli G. Impact of diabetes mellitus on the clinical response to cardiac resynchronization therapy in elderly people. J. Cardiovasc. Transl. Res. 2014;7:362–368. doi: 10.1007/s12265-014-9545-9. [DOI] [PubMed] [Google Scholar]
- 22.D'Ascia S.L., D'Ascia C., Marino V., et al. Cardiac resynchronisation therapy response predicts occurrence of atrial fibrillation in non-ischaemic dilated cardiomyopathy. Int. J. Clin. Pract. 2011;65:1149–1155. doi: 10.1111/j.1742-1241.2011.02732.x. [DOI] [PubMed] [Google Scholar]
- 23.Sardu C., Santamaria M., Rizzo M.R., et al. Telemonitoring in heart failure patients treated by cardiac resynchronisation therapy with defibrillator (CRT-D): the TELECART Study. Int. J. Clin. Pract. 2016 doi: 10.1111/ijcp.12823. [DOI] [PMC free article] [PubMed] [Google Scholar]