Abstract
AIM: To characterise the distribution of major growth plate proteoglycans in a group of infants who died of SIDS. METHODS: Nine such infants and eight age matched controls were selected from the necropsy files at the Adelaide Children's Hospital. Sections of rib and adjacent costal cartilage were stained for chondroitin-4-sulphate, chondroitin-6-sulphate, and keratan sulphate with antibodies 2-B-6, 3-B-3, and 5-D-4, respectively, using standard techniques. RESULTS: The distribution of proteoglycans within the extracellular matrix of the costochondral junction in the group of SIDS infants was identical with that found in control infants. CONCLUSION: Any changes present in the growth plate in cases of SIDS are most likely caused by secondary phenomena.
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- Buck G. M., Cookfair D. L., Michalek A. M., Nasca P. C., Standfast S. J., Sever L. E., Kramer A. A. Intrauterine growth retardation and risk of sudden infant death syndrome (SIDS) Am J Epidemiol. 1989 May;129(5):874–884. doi: 10.1093/oxfordjournals.aje.a115221. [DOI] [PubMed] [Google Scholar]
- Byard R. W. Possible mechanisms responsible for the sudden infant death syndrome. J Paediatr Child Health. 1991 Jun;27(3):147–157. doi: 10.1111/j.1440-1754.1991.tb00376.x. [DOI] [PubMed] [Google Scholar]
- Byers S., Caterson B., Hopwood J. J., Foster B. K. Immunolocation analysis of glycosaminoglycans in the human growth plate. J Histochem Cytochem. 1992 Feb;40(2):275–282. doi: 10.1177/40.2.1372629. [DOI] [PubMed] [Google Scholar]
- Gibson G. J., Francki K. T., Hopwood J. J., Foster B. K. Human and sheep growth-plate cartilage type X collagen synthesis and the influence of tissue storage. Biochem J. 1991 Jul 15;277(Pt 2):513–520. doi: 10.1042/bj2770513. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Peterson D. R., Benson E. A., Fisher L. D., Chinn N. A., Beckwith J. B. Postnatal growth and the sudden infant death syndrome. Am J Epidemiol. 1974 Jun;99(6):389–394. doi: 10.1093/oxfordjournals.aje.a121627. [DOI] [PubMed] [Google Scholar]
- Sorrell J. M., Lintala A. M., Mahmoodian F., Caterson B. Epitope-specific changes in chondroitin sulfate/dermatan sulfate proteoglycans as markers in the lymphopoietic and granulopoietic compartments of developing bursae of Fabricius. J Immunol. 1988 Jun 15;140(12):4263–4270. [PubMed] [Google Scholar]
- Williams S. M., Taylor B. J., Ford R. P., Nelson E. A. Growth velocity before sudden infant death. Arch Dis Child. 1990 Dec;65(12):1315–1318. doi: 10.1136/adc.65.12.1315. [DOI] [PMC free article] [PubMed] [Google Scholar]