Abstract
A 15 year old boy being treated for relapsed acute lymphoblastic leukaemia developed severe diarrhoea and abdominal pain which worsened despite empirical antibiotic treatment. A right hemicolectomy was performed. The caecum and ascending colon showed changes typical of neutropenic enterocolitis. Clostridium tertium was isolated from faeces, blood cultures, and from the resected gut wall, with no evidence of other organisms capable of causing such a condition. As far as is known, this is the first reported case in which neutropenic enterocolitis has been associated with well documented C tertium infection, an organism previously described as a cause of bacteraemia in neutropenic patients.
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- King A., Rampling A., Wight D. G., Warren R. E. Neutropenic enterocolitis due to Clostridium septicum infection. J Clin Pathol. 1984 Mar;37(3):335–343. doi: 10.1136/jcp.37.3.335. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Koea J. B., Shaw J. H. Surgical management of neutropenic enterocolitis. Br J Surg. 1989 Aug;76(8):821–824. doi: 10.1002/bjs.1800760821. [DOI] [PubMed] [Google Scholar]
- Lawrence G., Shann F., Freestone D. S., Walker P. D. Prevention of necrotising enteritis in Papua New Guinea by active immunisation. Lancet. 1979 Feb 3;1(8110):227–230. doi: 10.1016/s0140-6736(79)90764-5. [DOI] [PubMed] [Google Scholar]
- Newbold K. M. Neutropenic enterocolitis. Clinical and pathological review. Dig Dis. 1989;7(6):281–287. doi: 10.1159/000171228. [DOI] [PubMed] [Google Scholar]
- Slavin R. E., Dias M. A., Saral R. Cytosine arabinoside induced gastrointestinal toxic alterations in sequential chemotherapeutic protocols: a clinical-pathologic study of 33 patients. Cancer. 1978 Oct;42(4):1747–1759. doi: 10.1002/1097-0142(197810)42:4<1747::aid-cncr2820420413>3.0.co;2-t. [DOI] [PubMed] [Google Scholar]
- Speirs G., Warren R. E., Rampling A. Clostridium tertium septicemia in patients with neutropenia. J Infect Dis. 1988 Dec;158(6):1336–1340. doi: 10.1093/infdis/158.6.1336. [DOI] [PubMed] [Google Scholar]
- Valtonen M., Sivonen A., Elonen E. A cluster of seven cases of Clostridium tertium septicemia in neutropenic patients. Eur J Clin Microbiol Infect Dis. 1990 Jan;9(1):40–42. doi: 10.1007/BF01969532. [DOI] [PubMed] [Google Scholar]
- Yates P., MacGowan A. P., Potter M., White H., Slade R. R. Clostridia and neutropenic enterocolitis. Lancet. 1988 Jan 23;1(8578):185–185. doi: 10.1016/s0140-6736(88)92760-2. [DOI] [PubMed] [Google Scholar]