Abstract
AIMS: To study the spectrum of histological changes in the urinary tract caused by pelvic irradiation. METHODS: Biopsy specimens of ureter and bladder and cystectomy specimens from 18 patients who had received pelvic irradiation were studied and the histological features were arbitrarily grouped into early and late changes. RESULTS: A wide range of histological changes were noted of which submucosal inflammation, fibrosis, and epithelial damage were the commonest. Other less common features were interstitial haemorrhage, ureteritis and cystitis cystica, squamous metaplasia of vaginal type and perineural inflammation. CONCLUSIONS: Although epithelial changes were most prominent in early cases and stromal changes in the late cases, there was a continuing spectrum of epithelial damage which persisted many years after initial radiation. Similarly, submucosal fibrosis was equally prominent in early and late phases.
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- Antonakopoulos G. N., Hicks R. M., Berry R. J. The subcellular basis of damage to the human urinary bladder induced by irradiation. J Pathol. 1984 Jun;143(2):103–116. doi: 10.1002/path.1711430205. [DOI] [PubMed] [Google Scholar]
- Berthrong M. Pathologic changes secondary to radiation. World J Surg. 1986 Apr;10(2):155–170. doi: 10.1007/BF01658133. [DOI] [PubMed] [Google Scholar]
- Haboubi N. Y., Schofield P. F., Rowland P. L. The light and electron microscopic features of early and late phase radiation-induced proctitis. Am J Gastroenterol. 1988 Oct;83(10):1140–1144. [PubMed] [Google Scholar]
- Hopewell J. W. Letter: The late vascular effects of radiation. Br J Radiol. 1974 Feb;47(554):157–158. doi: 10.1259/0007-1285-47-554-157. [DOI] [PubMed] [Google Scholar]
- Strickland P. Complications of radiotherapy. Br J Hosp Med. 1980 Jun;23(6):552, 556-60, 565. [PubMed] [Google Scholar]