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. 1993 Jun;46(6):529–532. doi: 10.1136/jcp.46.6.529

Monocyte esterase deficiency in gastrointestinal cancer.

G M Markey 1, R C Curry 1, D Swain 1, T C Morris 1, J A McCormick 1, H D Alexander 1, S Edgar 1
PMCID: PMC501288  PMID: 8331174

Abstract

AIM--To substantiate the high incidence of monocyte esterase deficiency (MED) in gastrointestinal carcinoma already reported in a small group of patients; to compare the clinical findings in esterase deficient and esterase positive patients. METHODS--Peripheral blood smears (n = 22) or cytocentrifuge preparations (n = 52) of mononuclear cells from the peripheral blood of patients with gastrointestinal carcinoma were stained by the non-specific esterase stain (pH 5.8) using a batch technique. Samples containing > or = 85% esterase negative monocytes were identified at light microscopic examination. RESULTS--Seven of 74 patients were identified as having MED. This correlated exactly with the proportion (five of 46) found before, using an automated method, and was significantly higher than the 0.8% incidence in normal blood donors shown in that study. Comparison of the clinical details of the 12 MED patients with those of 105 esterase positive patients showed a significantly longer disease free survival in the MED cohort and increased occurrence of benign neoplasms--largely colorectal polyps--in this group also. Three patients had a borderline degree of deficiency and were excluded from comparisons, although they showed the same clinical tendencies as the MED group. CONCLUSIONS--There is a strong degree of association between monocyte esterase deficiency and gastrointestinal carcinoma. Further evidence must be sought to prove that the deficiency precedes the disease and therefore may predispose to it, or at least may identify subjects with such a predisposition. This could lead to early diagnosis and effective treatment of gastrointestinal carcinoma in a sizeable proportion of patients.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bell A. L., Markey G. M., McCaigue M. D., Middleton D., McCormick J. A., Wilson A. G., Morris T. C. Heredofamilial deficiency of monocyte esterase in patients with rheumatoid arthritis. Ann Rheum Dis. 1992 May;51(5):668–670. doi: 10.1136/ard.51.5.668. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Levine M. S., Fox N. L., Thompson B., Taylor W., Darlington A. C., Van der Hoeden J., Emmett E. A., Rutten W. Inhibition of esterase activity and an undercounting of circulating monocytes in a population of production workers. J Occup Med. 1986 Mar;28(3):207–211. doi: 10.2196/44146. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Li C. Y., Lam K. W., Yam L. T. Esterases in human leukocytes. J Histochem Cytochem. 1973 Jan;21(1):1–12. doi: 10.1177/21.1.1. [DOI] [PubMed] [Google Scholar]
  4. Mandel J. S., Berlinger N. T., Kay N., Connett J., Reape M., 3rd Organophosphate exposure inhibits non-specific esterase staining in human blood monocytes. Am J Ind Med. 1989;15(2):207–212. doi: 10.1002/ajim.4700150209. [DOI] [PubMed] [Google Scholar]
  5. Markey G. M., McCormick J. A., Morris T. C., Alexander H. D., Nolan L., Morgan L. M., Reynolds M. E., Edgar S., Bell A. L., McCaigue M. D. Monocyte esterase deficiency in malignant neoplasia. J Clin Pathol. 1990 Apr;43(4):282–286. doi: 10.1136/jcp.43.4.282. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Markey G. M., Morris T. C., Alexander H. D., Kyle A., Middleton D., Turner A., Burnside P., Drexler H. G., Gaedicke G., Hartmen W. Monocyte esterase? A factor involved in the pathogenesis of lymphoproliferative neoplasia. Leukemia. 1987 Mar;1(3):236–239. [PubMed] [Google Scholar]
  7. McCormick J. A., Markey G. M., Morris T. C., Auld P. W., Alexander H. D. Lactoferrin inducible monocyte cytotoxicity defective in esterase deficient monocytes. Br J Haematol. 1991 Mar;77(3):287–290. doi: 10.1111/j.1365-2141.1991.tb08572.x. [DOI] [PubMed] [Google Scholar]
  8. McCormick J. A., Markey G. M., Morris T. C., Auld P. W., Alexander H. D. Lactoferrin inducible monocyte cytotoxicity defective in esterase deficient monocytes. Br J Haematol. 1991 Mar;77(3):287–290. doi: 10.1111/j.1365-2141.1991.tb08572.x. [DOI] [PubMed] [Google Scholar]
  9. Newcombe D. S. Immune surveillance, organophosphorus exposure, and lymphomagenesis. Lancet. 1992 Feb 29;339(8792):539–541. doi: 10.1016/0140-6736(92)90349-8. [DOI] [PubMed] [Google Scholar]
  10. Oehmichen M., Pedal I., Besserer K., Gencic M. Inhibition of non-specific leukocyte esterase activity. Absence of monocyte esterase activity due to phosphoric and thiophosphoric acid ester intoxication. Forensic Sci Int. 1984 Jul;25(3):181–189. doi: 10.1016/0379-0738(84)90192-0. [DOI] [PubMed] [Google Scholar]
  11. Oertel J., Hagner G., Kastner M., Huhn D. The relevance of alpha-naphthyl acetate esterases to various monocyte functions. Br J Haematol. 1985 Dec;61(4):717–726. doi: 10.1111/j.1365-2141.1985.tb02886.x. [DOI] [PubMed] [Google Scholar]
  12. Ross D. W., Bishop C., Henderson A., Kaplow L. Whole blood staining in suspension for nonspecific esterase and alkaline phosphatase analyzed with a Technicon H-1. Cytometry. 1990;11(4):552–555. doi: 10.1002/cyto.990110415. [DOI] [PubMed] [Google Scholar]

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