Skip to main content
Journal of Clinical Pathology logoLink to Journal of Clinical Pathology
. 1993 Jun;46(6):570–572. doi: 10.1136/jcp.46.6.570

Primary splenic lymphoma with filiform ultrastructure.

U R Suresh 1, B P Eyden 1, S S Banerjee 1, N L Reeve 1
PMCID: PMC501301  PMID: 8331186

Abstract

A case of primary large cell splenic lymphoma of B lineage exhibiting filiform cell appearance is reported. The patient presented with massive splenomegaly, and following spontaneous splenic rupture, died of adult respiratory distress syndrome. The clinical aspects of the case, notably a lymphoma arising as a primary tumour in the spleen, with spontaneous spleen rupture and rapid fatal outcome, in combination with the filiform appearance of the lymphoma on electron microscopic examination, constitute an unusual combination of features. As far as is known, this B cell neoplasm is only the second primary splenic lymphoma of filiform type to be recorded.

Full text

PDF
570

Images in this article

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bernier V., Azar H. A. Filiform large-cell lymphomas. An ultrastructural and immunohistochemical study. Am J Surg Pathol. 1987 May;11(5):387–396. doi: 10.1097/00000478-198705000-00008. [DOI] [PubMed] [Google Scholar]
  2. Bostick W. L. Primary Splenic Neoplasms. Am J Pathol. 1945 Nov;21(6):1143–1165. [PMC free article] [PubMed] [Google Scholar]
  3. Franchino C., Reich C., Distenfeld A., Ubriaco A., Knowles D. M. A clinicopathologically distinctive primary splenic histiocytic neoplasm. Demonstration of its histiocyte derivation by immunophenotypic and molecular genetic analysis. Am J Surg Pathol. 1988 May;12(5):398–404. [PubMed] [Google Scholar]
  4. Hansmann M. L., Fellbaum C., Bohm A. Large cell anaplastic lymphoma: evaluation of immunophenotype on paraffin and frozen sections in comparison with ultrastructural features. Virchows Arch A Pathol Anat Histopathol. 1991;418(5):427–433. doi: 10.1007/BF01605929. [DOI] [PubMed] [Google Scholar]
  5. Ishihara T., Takahashi M., Uchino F., Matsumoto N. A filiform large cell lymphoma in the spleen: a case report with immunohistochemical and electron microscopic study. Ultrastruct Pathol. 1990 Mar-Apr;14(2):193–199. doi: 10.1080/01913129009025131. [DOI] [PubMed] [Google Scholar]
  6. Kinney M. C., Glick A. D., Stein H., Collins R. D. Comparison of anaplastic large cell Ki-1 lymphomas and microvillous lymphomas in their immunologic and ultrastructural features. Am J Surg Pathol. 1990 Nov;14(11):1047–1060. doi: 10.1097/00000478-199011000-00006. [DOI] [PubMed] [Google Scholar]
  7. Kraemer B. B., Osborne B. M., Butler J. J. Primary splenic presentation of malignant lymphoma and related disorders. A study of 49 cases. Cancer. 1984 Oct 15;54(8):1606–1619. doi: 10.1002/1097-0142(19841015)54:8<1606::aid-cncr2820540823>3.0.co;2-5. [DOI] [PubMed] [Google Scholar]
  8. Melo J. V., Hegde U., Parreira A., Thompson I., Lampert I. A., Catovsky D. Splenic B cell lymphoma with circulating villous lymphocytes: differential diagnosis of B cell leukaemias with large spleens. J Clin Pathol. 1987 Jun;40(6):642–651. doi: 10.1136/jcp.40.6.642. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Mulligan S. P., Matutes E., Dearden C., Catovsky D. Splenic lymphoma with villous lymphocytes: natural history and response to therapy in 50 cases. Br J Haematol. 1991 Jun;78(2):206–209. doi: 10.1111/j.1365-2141.1991.tb04417.x. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Clinical Pathology are provided here courtesy of BMJ Publishing Group

RESOURCES