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. 2016 May 20;102(17):1342–1347. doi: 10.1136/heartjnl-2014-306775

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Stepwise treatment of patients with symptomatic (NYHA II–IV) heart failure with reduced ejection fraction. Progressive therapies should be added in a stepwise fashion. Where two or more options exist on a step the most appropriate therapy for the patient based on concomitant medication or the presence of other patient factors should be made. NYHA, New York Heart Association; ARB, angiotensin receptor blocker; ACE, angiotensin converting enzyme inhibitor; ICD, implantable cardioverter defibrillator; CRT-P, cardiac resynchronisation therapy-pacemaker; CRT-D, cardiac resynchronisation therapy-defibrillator; LVAD, left ventricular assist device.