Abstract
AIMS--To examine veins histologically from different sites in the body to study the effect of venous pressure; and to examine veins used as aortocoronary grafts. METHODS--The axillary vein, femoral vein at the inguinal ligament, the short saphenous vein at the knee and the long saphenous vein at the ankle were removed from 24 necropsy cases of patients aged 2 months to 80 years. Fifteen varicose saphenous veins and 12 aortocoronary grafts removed at surgery were obtained. All were examined histologically. RESULTS--Varying degrees of intimal thickening composed of collagen, elastin, and smooth muscle were found. These changes were most noticeable in the varicose veins. Intimal changes were also seen related to valves and to adjacent arteries. No clinically relevant lipid was seen in the native veins, though atheromatous changes were seen in the grafts. CONCLUSIONS--Venous changes are related to venous pressure, to local haemodynamic effects, and probably to hypoxia. The changes are often focal and seem to be sequential in their formation. True atheroma is seen in the aortocoronary grafts but is not seen in native veins and this may be the result of additional factors.
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- Barboriak J. J., Pintar K., Van Horn D. L., Batayias G. E., Korns M. E. Pathologic findings in the aortocoronary vein grafts. A scanning electron microscope study. Atherosclerosis. 1978 Jan;29(1):69–80. doi: 10.1016/0021-9150(78)90095-3. [DOI] [PubMed] [Google Scholar]
- Cox J. L., Chiasson D. A., Gotlieb A. I. Stranger in a strange land: the pathogenesis of saphenous vein graft stenosis with emphasis on structural and functional differences between veins and arteries. Prog Cardiovasc Dis. 1991 Jul-Aug;34(1):45–68. doi: 10.1016/0033-0620(91)90019-i. [DOI] [PubMed] [Google Scholar]
- Kern W. H., Wells W. J., Meyer B. W. The pathology of surgically excised aortocoronary saphenous vein bypass grafts. Am J Surg Pathol. 1981 Jul;5(5):491–496. doi: 10.1097/00000478-198107000-00008. [DOI] [PubMed] [Google Scholar]
- McCann R. L., Larson R. M., Mitchener J. S., Hagen P. O. Histological and biochemical studies of vascular autografts. Artery. 1980;6(4):267–279. [PubMed] [Google Scholar]
- Noishiki Y. Pattern of arrangement of smooth muscle cells in neointimae of synthetic vascular prostheses. J Thorac Cardiovasc Surg. 1978 Jun;75(6):894–901. [PubMed] [Google Scholar]
- Ramos J. R., Berger K., Mansfield P. B., Sauvage L. R. Histologic fate and endothelial changes of distended and nondistended vein grafts. Ann Surg. 1976 Mar;183(3):205–228. doi: 10.1097/00000658-197603000-00001. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Ramos J. R., Berger K., Mansfield P. B., Sauvage L. R. Histologic fate and endothelial changes of distended and nondistended vein grafts. Ann Surg. 1976 Mar;183(3):205–228. doi: 10.1097/00000658-197603000-00001. [DOI] [PMC free article] [PubMed] [Google Scholar]
- STUART M., MAGAREY F. R. The great veins in venous hypertension. J Pathol Bacteriol. 1960 Apr;79:319–323. doi: 10.1002/path.1700790213. [DOI] [PubMed] [Google Scholar]
- Saffitz J. E. Toward a unified concept of vascular smooth muscle response to injury. Am J Clin Pathol. 1992 Jan;97(1):1–3. doi: 10.1093/ajcp/97.1.1. [DOI] [PubMed] [Google Scholar]
- Schwartz S. M., Reidy M. A. Common mechanisms of proliferation of smooth muscle in atherosclerosis and hypertension. Hum Pathol. 1987 Mar;18(3):240–247. doi: 10.1016/s0046-8177(87)80006-0. [DOI] [PubMed] [Google Scholar]
- Sottiurai V. S., Yao J. S., Flinn W. R., Batson R. C. Intimal hyperplasia and neointima: An ultrastructural analysis of thrombosed grafts in humans. Surgery. 1983 Jun;93(6):809–817. [PubMed] [Google Scholar]