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Effect of RN-1 on HbF and F cells in non-anemic baboons treated with RN-1. (A) Effect of RN-1 on HbF (left) and F cells (right) in 3 non-anemic baboons. PA8696 was treated for ten weeks (0.2–0.25 mg/kg/d; 5d/wk; sc). PA8698 and PA8695 were treated for six weeks (0.25 mg/kg/d; 5d/week/sc). (B) Flow cytometric analysis of F cells and F reticulocytes on d1 and d70 following RN-1 treatment in a non-anemic baboon (PA8696).
