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. Author manuscript; available in PMC: 2017 Sep 6.
Published in final edited form as: Structure. 2016 Aug 18;24(9):1562–1572. doi: 10.1016/j.str.2016.07.001

Fig. 6. A recombinant influenza B virus with a R246A NS1B mutation that suppresses CTD homo-dimerization is attenuated in viral replication.

Fig. 6

(a) Growth curves of wt and R246A mutant viruses in A549 cells infected with 0.1 pfu / cell. (b) A549 cells were infected with 5 pfu / cell of wt or R246A mutant virus, and at the indicated times after infected cell extracts were assayed by immunoblots for activated (phosphorylated) IRF3, total IRF3, and NS1B levels, as described in the legend of Figure 5.