Abstract
AIMS--To study the value of wide needle (19 gauge) aspiration cytology in the diagnosis of lymph node disease in Zambia in the absence of a trained cytologist. METHODS--Patients (n = 304) referred for surgical biopsy of an enlarged peripheral lymph node were studied prospectively. Surgical biopsy was routinely preceded by 19 gauge needle aspiration of the same node; aspirates were stained by haematoxylin and eosin and Ziehl Neelsen stains. RESULTS--Of 232 aspirates, 182 contained sufficient material for cytological characterisation. Tuberculosis was diagnosed or suspected in 122 of 126 aspirates with histologically confirmed tuberculous lymphadenitis; reactive follicular hyperplasia in 31 of 38 patients with primary HIV lymphadenopathy; malignancy in all five patients with malignant nodes; and Kaposi's disease in four of nine patients with this. Tuberculous lymphadenitis was falsely suspected in four patients, as was reactive follicular hyperplasia in four, and Kaposi's disease in four. CONCLUSIONS--Wide needle aspiration cytology is useful in the diagnosis of lymphadenopathy in Central Africa, with the exception of lymphadenopathic Kaposi's disease.
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- Bem C., Barucha H., Patil P. S. Parotid disease and human immunodeficiency virus infection in Zambia. Br J Surg. 1992 Aug;79(8):768–770. doi: 10.1002/bjs.1800790818. [DOI] [PubMed] [Google Scholar]
- Bottles K., Miller T. R., Cohen M. B., Ljung B. M. Fine needle aspiration biopsy. Has its time come? Am J Med. 1986 Sep;81(3):525–531. doi: 10.1016/0002-9343(86)90309-8. [DOI] [PubMed] [Google Scholar]
- Ewing E. P., Jr, Chandler F. W., Spira T. J., Brynes R. K., Chan W. C. Primary lymph node pathology in AIDS and AIDS-related lymphadenopathy. Arch Pathol Lab Med. 1985 Nov;109(11):977–981. [PubMed] [Google Scholar]
- Frable W. J. Thin-needle aspiration biopsy. A personal experience with 469 cases. Am J Clin Pathol. 1976 Feb;65(2):168–182. doi: 10.1093/ajcp/65.2.168. [DOI] [PubMed] [Google Scholar]
- Hales M., Bottles K., Miller T., Donegan E., Ljung B. M. Diagnosis of Kaposi's sarcoma by fine-needle aspiration biopsy. Am J Clin Pathol. 1987 Jul;88(1):20–25. doi: 10.1093/ajcp/88.1.20. [DOI] [PubMed] [Google Scholar]
- Kline T. S., Kannan V., Kline I. K. Lymphadenopathy and aspiration biopsy cytology. Review of 376 superficial nodes. Cancer. 1984 Sep 15;54(6):1076–1081. doi: 10.1002/1097-0142(19840915)54:6<1076::aid-cncr2820540624>3.0.co;2-w. [DOI] [PubMed] [Google Scholar]
- Lau S. K., Wei W. I., Hsu C., Engzell U. C. Fine needle aspiration biopsy of tuberculous cervical lymphadenopathy. Aust N Z J Surg. 1988 Dec;58(12):947–950. doi: 10.1111/j.1445-2197.1988.tb00098.x. [DOI] [PubMed] [Google Scholar]
- Metre M. S., Jayaram G. Acid-fast bacilli in aspiration smears from tuberculous lymph nodes. An analysis of 255 cases. Acta Cytol. 1987 Jan-Feb;31(1):17–19. [PubMed] [Google Scholar]
- Orell S. R. Fine needle aspiration biopsy in perspective. Pathology. 1982 Apr;14(2):113–114. doi: 10.3109/00313028209061280. [DOI] [PubMed] [Google Scholar]
- Patra A. K., Nanda B. K., Mohapatra B. K., Panda A. K. Diagnosis of lymphadenopathy by fine needle aspiration cytology. Indian J Pathol Microbiol. 1983 Oct;26(4):273–278. [PubMed] [Google Scholar]
- Philips J. N., Goodman B. N. Clinching the diagnosis: fine needle aspiration cytology. Pathology. 1987 Oct;19(4):371–376. doi: 10.3109/00313028709103886. [DOI] [PubMed] [Google Scholar]
- Rácz P., Tenner-Rácz K., Kahl C., Feller A. C., Kern P., Dietrich M. Spectrum of morphologic changes of lymph nodes from patients with AIDS or AIDS-related complexes. Prog Allergy. 1986;37:81–181. doi: 10.1159/000318442. [DOI] [PubMed] [Google Scholar]