Skip to main content
PMC home page
Journal of Clinical Pathology logoLink to Journal of Clinical Pathology
. 1999 Oct;52(10):780–781. doi: 10.1136/jcp.52.10.780

Severe hypoglycaemia caused by raised insulin-like growth factor II in disseminated breast cancer.

E M Bessell 1, C Selby 1, I O Ellis 1
PMCID: PMC501577  PMID: 10674040

Abstract

A 60 year old woman with disseminated ductal carcinoma of the breast developed non-islet cell tumour induced hypoglycaemia (NICTH). The concentrations of the two insulin-like growth factors, IGF-I and IGF-II, were < 2 nmol/l and 94.1 nmol/l, respectively. The IGF-II to IGF-I ratio was > 47 (normal < 10). Insulin (< 3 mu/l) and C peptide (< 100 pmol/l) were both undetectable.

Full text

PDF
780

Images in this article

781Image
on p.781

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Daughaday W. H. Hypoglycemia in patients with non-islet cell tumors. Endocrinol Metab Clin North Am. 1989 Mar;18(1):91–101. [PubMed] [Google Scholar]
  2. Doege K. W. FIBRO-SARCOMA OF THE MEDIASTINUM. Ann Surg. 1930 Nov;92(5):955–960. [PMC free article] [PubMed] [Google Scholar]
  3. Luna-Moré S., Gonzalez B., Acedo C., Rodrigo I., Luna C. Invasive micropapillary carcinoma of the breast. A new special type of invasive mammary carcinoma. Pathol Res Pract. 1994 Aug;190(7):668–674. doi: 10.1016/S0344-0338(11)80745-4. [DOI] [PubMed] [Google Scholar]
  4. Macaulay V. M. Insulin-like growth factors and cancer. Br J Cancer. 1992 Mar;65(3):311–320. doi: 10.1038/bjc.1992.65. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Siriaunkgul S., Tavassoli F. A. Invasive micropapillary carcinoma of the breast. Mod Pathol. 1993 Nov;6(6):660–662. [PubMed] [Google Scholar]
  6. Teale J. D., Blum W. F., Marks V. Alleviation of non-islet cell tumour hypoglycaemia by growth hormone therapy is associated with changes in IGF binding protein-3. Ann Clin Biochem. 1992 May;29(Pt 3):314–323. doi: 10.1177/000456329202900312. [DOI] [PubMed] [Google Scholar]
  7. Teale J. D., Marks V. Inappropriately elevated plasma insulin-like growth factor II in relation to suppressed insulin-like growth factor I in the diagnosis of non-islet cell tumour hypoglycaemia. Clin Endocrinol (Oxf) 1990 Jul;33(1):87–98. doi: 10.1111/j.1365-2265.1990.tb00469.x. [DOI] [PubMed] [Google Scholar]
  8. Toropainen E. M., Lipponen P. K., Syrjanen K. J. Expression of insulin-like growth factor II in female breast cancer as related to established prognostic factors and long-term prognosis. Anticancer Res. 1995 Nov-Dec;15(6B):2669–2674. [PubMed] [Google Scholar]

Articles from Journal of Clinical Pathology are provided here courtesy of BMJ Publishing Group

RESOURCES