Abstract
A 67 year old man with myelodysplasia was admitted as an emergency with a six week history of rectal bleeding and diarrhoea. Barium enema showed an irregular polypoid filling defect in the lateral wall of the proximal rectum near the rectosigmoid junction. Histology showed this to be a granulocytic sarcoma (extramedullary granulocytic leukaemia; chloroma) infiltrating the bowel. A low index of suspicion of this lesion results in an incorrect diagnosis in many such cases. A chloroacetate esterase immunoperoxidase stain will confirm the granulocytic nature of the tumour cells.
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- Catalano M. F., Levin B., Hart R. S., Troncoso P., DuBrow R. A., Estey E. H. Granulocytic sarcoma of the colon. Gastroenterology. 1991 Feb;100(2):555–559. doi: 10.1016/0016-5085(91)90230-i. [DOI] [PubMed] [Google Scholar]
- Lugassy G., Gimon Z., Okon E., Michaeli J. Acute abdomen due to granulocytic sarcoma of the terminal ileum. Eur J Surg Oncol. 1988 Oct;14(5):445–448. [PubMed] [Google Scholar]
- Meis J. M., Butler J. J., Osborne B. M., Manning J. T. Granulocytic sarcoma in nonleukemic patients. Cancer. 1986 Dec 15;58(12):2697–2709. doi: 10.1002/1097-0142(19861215)58:12<2697::aid-cncr2820581225>3.0.co;2-r. [DOI] [PubMed] [Google Scholar]
- Rosenthal S., Canellos G. P., DeVita V. T., Jr, Gralnick H. R. Characteristics of blast crisis in chronic granulocytic leukemia. Blood. 1977 May;49(5):705–714. [PubMed] [Google Scholar]
- Rottenberg G. T., Thomas B. M. Case report: granulocytic sarcoma of the small bowel--a rare presentation of leukaemia. Clin Radiol. 1994 Jul;49(7):501–502. doi: 10.1016/s0009-9260(05)81752-0. [DOI] [PubMed] [Google Scholar]