Abstract
AIMS--To identify the number and geographical distribution of post mortem examinations performed on HIV infected cadavers; to identify the areas that perform post mortem examinations so that, by invitation and discussion, a national post mortem network could be initiated. METHODS--A nationwide survey of Royal College of Pathologists' district tutors (n = 216) was done by postal questionnaire. These were completed by the district tutors or passed on to their histopathologist colleagues. The results were collated after three months. After one follow up letter, an 86% response rate, which is a significant sample, was achieved. RESULTS--Twenty eight per cent of respondents were performing HIV post mortem examinations. Of those who were not performing them (30%), the lack of clinical or coroner requests was the most common explanation. All regions provide facilities for HIV post mortem examinations, as judged by the responses. CONCLUSIONS--These findings are of singular importance as it is the first United Kingdom survey investigating the distribution of post mortem examinations on HIV infected cadavers. Studying post mortem material using a systemic, coordinated collection of brain tissue is essential to increase knowledge of a new disease of pandemic proportions.
Full text
PDF



Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Budka H., Costanzi G., Cristina S., Lechi A., Parravicini C., Trabattoni R., Vago L. Brain pathology induced by infection with the human immunodeficiency virus (HIV). A histological, immunocytochemical, and electron microscopical study of 100 autopsy cases. Acta Neuropathol. 1987;75(2):185–198. doi: 10.1007/BF00687080. [DOI] [PubMed] [Google Scholar]
- Budka H., Wiley C. A., Kleihues P., Artigas J., Asbury A. K., Cho E. S., Cornblath D. R., Dal Canto M. C., DeGirolami U., Dickson D. HIV-associated disease of the nervous system: review of nomenclature and proposal for neuropathology-based terminology. Brain Pathol. 1991 Apr;1(3):143–152. doi: 10.1111/j.1750-3639.1991.tb00653.x. [DOI] [PubMed] [Google Scholar]
- Catalan J. Psychiatric manifestations of HIV disease. Baillieres Clin Gastroenterol. 1990 Jun;4(2):547–562. doi: 10.1016/0950-3528(90)90016-a. [DOI] [PubMed] [Google Scholar]
- Everall I. P., Luthert P. J., Lantos P. L. Neuronal loss in the frontal cortex in HIV infection. Lancet. 1991 May 11;337(8750):1119–1121. doi: 10.1016/0140-6736(91)92786-2. [DOI] [PubMed] [Google Scholar]
- Goldman L., Sayson R., Robbins S., Cohn L. H., Bettmann M., Weisberg M. The value of the autopsy in three medical eras. N Engl J Med. 1983 Apr 28;308(17):1000–1005. doi: 10.1056/NEJM198304283081704. [DOI] [PubMed] [Google Scholar]
- Goodale F. The future of the autopsy. Am J Clin Pathol. 1978 Feb;69(2 Suppl):260–262. [PubMed] [Google Scholar]
- Ho D. D., Rota T. R., Schooley R. T., Kaplan J. C., Allan J. D., Groopman J. E., Resnick L., Felsenstein D., Andrews C. A., Hirsch M. S. Isolation of HTLV-III from cerebrospinal fluid and neural tissues of patients with neurologic syndromes related to the acquired immunodeficiency syndrome. N Engl J Med. 1985 Dec 12;313(24):1493–1497. doi: 10.1056/NEJM198512123132401. [DOI] [PubMed] [Google Scholar]
- KINGERY F. A. OSTEOPOROSIS, FRACTURES, AND HEPARIN THERAPY. JAMA. 1965 Jul 12;193:152–152. [PubMed] [Google Scholar]
- KINGERY F. A. ST. LOUIS ENCEPHALITIS. JAMA. 1965 Jul 12;193:150–151. [PubMed] [Google Scholar]
- KINGERY F. A. THE SELF-HEALING "CANCER". JAMA. 1965 Jul 12;193:149–149. doi: 10.1001/jama.1965.03090020063015. [DOI] [PubMed] [Google Scholar]
- Lantos P. L., McLaughlin J. E., Schoitz C. L., Berry C. L., Tighe J. R. Neuropathology of the brain in HIV infection. Lancet. 1989 Feb 11;1(8633):309–311. doi: 10.1016/s0140-6736(89)91316-0. [DOI] [PubMed] [Google Scholar]
- Navia B. A., Jordan B. D., Price R. W. The AIDS dementia complex: I. Clinical features. Ann Neurol. 1986 Jun;19(6):517–524. doi: 10.1002/ana.410190602. [DOI] [PubMed] [Google Scholar]
- Petito C. K., Cho E. S., Lemann W., Navia B. A., Price R. W. Neuropathology of acquired immunodeficiency syndrome (AIDS): an autopsy review. J Neuropathol Exp Neurol. 1986 Nov;45(6):635–646. doi: 10.1097/00005072-198611000-00003. [DOI] [PubMed] [Google Scholar]
- Price R. W., Brew B., Sidtis J., Rosenblum M., Scheck A. C., Cleary P. The brain in AIDS: central nervous system HIV-1 infection and AIDS dementia complex. Science. 1988 Feb 5;239(4840):586–592. doi: 10.1126/science.3277272. [DOI] [PubMed] [Google Scholar]
- Price R. W., Sidtis J. J., Brew B. J. AIDS dementia complex and HIV-1 infection: a view from the clinic. Brain Pathol. 1991 Apr;1(3):155–162. doi: 10.1111/j.1750-3639.1991.tb00655.x. [DOI] [PubMed] [Google Scholar]
- Roberts W. C. The autopsy: its decline and a suggestion for its revival. N Engl J Med. 1978 Aug 17;299(7):332–338. doi: 10.1056/NEJM197808172990704. [DOI] [PubMed] [Google Scholar]
- Sharer L. R., Cho E. S., Epstein L. G. Multinucleated giant cells and HTLV-III in AIDS encephalopathy. Hum Pathol. 1985 Aug;16(8):760–760. doi: 10.1016/s0046-8177(85)80245-8. [DOI] [PubMed] [Google Scholar]
- Snider W. D., Simpson D. M., Nielsen S., Gold J. W., Metroka C. E., Posner J. B. Neurological complications of acquired immune deficiency syndrome: analysis of 50 patients. Ann Neurol. 1983 Oct;14(4):403–418. doi: 10.1002/ana.410140404. [DOI] [PubMed] [Google Scholar]
- Wiley C. A., Masliah E., Morey M., Lemere C., DeTeresa R., Grafe M., Hansen L., Terry R. Neocortical damage during HIV infection. Ann Neurol. 1991 Jun;29(6):651–657. doi: 10.1002/ana.410290613. [DOI] [PubMed] [Google Scholar]
- Wiley C. A., Schrier R. D., Nelson J. A., Lampert P. W., Oldstone M. B. Cellular localization of human immunodeficiency virus infection within the brains of acquired immune deficiency syndrome patients. Proc Natl Acad Sci U S A. 1986 Sep;83(18):7089–7093. doi: 10.1073/pnas.83.18.7089. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Wilkes M. S., Fortin A. H., Felix J. C., Godwin T. A., Thompson W. G. Value of necropsy in acquired immunodeficiency syndrome. Lancet. 1988 Jul 9;2(8602):85–88. doi: 10.1016/s0140-6736(88)90014-1. [DOI] [PubMed] [Google Scholar]
