Table 2. Risk of Ischemic Stroke Associated with Premature Atrial Contractions (N=22,975).

PAC	Cases	Person-years	Incidence Rate per 1000 person-years	Model 1* HR (95%CI)	P-value	Model 2† HR (95%CI)	P-value
Absent	481	152,489	3.2 (2.9, 3.4)	1.0	-	1.0	-
Present	68	11,299	6.0 (4.7, 7.6)	1.37 (1.06, 1.77)	0.018	1.34 (1.04, 1.74)	0.025

^*Adjusted for age, sex, race, age*race, education, income, and region of residence.

^†Adjusted for Model 1 covariates plus systolic blood pressure, smoking, diabetes, low-density lipoprotein cholesterol, left ventricular hypertrophy, antihypertensive medications, lipid-lowering therapies, aspirin, and coronary heart disease.

CI=confidence interval; HR=hazard ratio; PAC=premature atrial contraction.