Skip to main content
Journal of Clinical Pathology logoLink to Journal of Clinical Pathology
. 1994 Apr;47(4):364–366. doi: 10.1136/jcp.47.4.364

CD4+ lymphocytopenia due to common variable immunodeficiency mimicking AIDS.

R S Kaczmarski 1, A D Webster 1, J Moxham 1, F Davison 1, S Sutherland 1, G J Mufti 1
PMCID: PMC501945  PMID: 8027379

Abstract

There are an increasing number of published reports of patients with acquired immunodeficiency without evidence of HIV infection, who have been labelled as having "idiopathic CD4+ lymphocytopenia". The case is reported here of a young man who presented with Pneumocystis carinii pneumonia (PCP), CD4+ lymphopenia, and hypogammaglobulinaemia attributable to common variable immunodeficiency (CVID). The presentation of this condition, with many of the clinical and laboratory features of AIDS, highlights CVID as a diagnosis to be considered in the differential diagnosis of CD4+ lymphocytopenia.

Full text

PDF
364

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Birx D. L., Redfield R. R., Tencer K., Fowler A., Burke D. S., Tosato G. Induction of interleukin-6 during human immunodeficiency virus infection. Blood. 1990 Dec 1;76(11):2303–2310. [PubMed] [Google Scholar]
  2. Cooper D. A., Tindall B., Wilson E. J., Imrie A. A., Penny R. Characterization of T lymphocyte responses during primary infection with human immunodeficiency virus. J Infect Dis. 1988 May;157(5):889–896. doi: 10.1093/infdis/157.5.889. [DOI] [PubMed] [Google Scholar]
  3. Davis S. D., Eidelman S., Loop J. W. Nodular lymphoid hyperplasia of the small intestine and sarcoidosis. Arch Intern Med. 1970 Oct;126(4):668–672. [PubMed] [Google Scholar]
  4. Hermans P. E., Diaz-Buxo J. A., Stobo J. D. Idiopathic late-onset immunoglobulin deficiency. Clinical observations in 50 patients. Am J Med. 1976 Aug;61(2):221–237. doi: 10.1016/0002-9343(76)90173-x. [DOI] [PubMed] [Google Scholar]
  5. Imagawa D. T., Lee M. H., Wolinsky S. M., Sano K., Morales F., Kwok S., Sninsky J. J., Nishanian P. G., Giorgi J., Fahey J. L. Human immunodeficiency virus type 1 infection in homosexual men who remain seronegative for prolonged periods. N Engl J Med. 1989 Jun 1;320(22):1458–1462. doi: 10.1056/NEJM198906013202205. [DOI] [PubMed] [Google Scholar]
  6. Laurence J., Siegal F. P., Schattner E., Gelman I. H., Morse S. Acquired immunodeficiency without evidence of infection with human immunodeficiency virus types 1 and 2. Lancet. 1992 Aug 1;340(8814):273–274. doi: 10.1016/0140-6736(92)92359-n. [DOI] [PubMed] [Google Scholar]
  7. Meyer P. R., Yanagihara E. T., Parker J. W., Lukes R. J. A distinctive follicular hyperplasia in the acquired immune deficiency syndrome (AIDS) and the AIDS related complex. A pre-lymphomatous state for B cell lymphomas? Hematol Oncol. 1984 Oct-Dec;2(4):319–347. doi: 10.1002/hon.2900020403. [DOI] [PubMed] [Google Scholar]
  8. Spickett G. P., Matamoros N., Farrant J. Lymphocyte surface phenotype in common variable immunodeficiency. Dis Markers. 1992 Mar-Apr;10(2):67–80. [PubMed] [Google Scholar]
  9. Tindall B., Barker S., Donovan B., Barnes T., Roberts J., Kronenberg C., Gold J., Penny R., Cooper D. Characterization of the acute clinical illness associated with human immunodeficiency virus infection. Arch Intern Med. 1988 Apr;148(4):945–949. [PubMed] [Google Scholar]
  10. Wolinsky S. M., Rinaldo C. R., Kwok S., Sninsky J. J., Gupta P., Imagawa D., Farzadegan H., Jacobson L. P., Grovit K. S., Lee M. H. Human immunodeficiency virus type 1 (HIV-1) infection a median of 18 months before a diagnostic western blot. Evidence from a cohort of homosexual men. Ann Intern Med. 1989 Dec 15;111(12):961–972. doi: 10.7326/0003-4819-111-12-961. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Clinical Pathology are provided here courtesy of BMJ Publishing Group

RESOURCES