Erratum to: Adv Ther (2016) DOI 10.1007/s12325-016-0368-8
During typesetting of the aforementioned article, a number of erroneous commas were inadvertently introduced into the quantities cited. Furthermore, the authors noted that the description of Fig. 2 was incorrect in the results section. As such, the following corrections should be highlighted:
In the Results section of the Abstract, the following sentence is incorrect ‘We identified 4,85,895 orthopedic surgery patients with 1,74,805 (36%) who had received IV acetaminophen.’ and should read ‘We identified 485,895 orthopedic surgery patients with 174,805 (36%) who had received IV acetaminophen’.
In the Results section, the following sentence is incorrect ‘We identified 4,85,895 orthopedic surgery patients who were eligible for our study of which 1,74,805 (36%) had been managed with IV acetaminophen and opioids and 3,11,090 (64%) had been managed with IV opioids alone.’ and should read as follows ‘We identified 485,895 orthopedic surgery patients who were eligible for our study of which 174,805 (36%) had been managed with IV acetaminophen and opioids and 311,090 (64%) had been managed with IV opioids alone’.
Also in the Results section, the following sentence is incorrect ‘Subgroup analyses by surgery type revealed that LOS was consistently lower across all surgery groups, though only the fracture and other subgroups were statistically significantly lower. These subgroup analyses also showed that while costs were estimated to be lower for most groups, they were slightly higher for total knee replacements and other surgeries, none of which were statistically significantly different. Opioid dose was also lower for all groups (non-significant with the exception of other) except MED was slightly higher for knee revisions (1.1 mg, P = 0.8; Fig. 2).’ And should read as follows ‘Subgroup analyses by surgery type revealed that LOS was statistically significantly lower for all groups with the exception of knee revision. These subgroup analyses also showed that while costs were estimated to be lower for most groups, they were slightly higher for total knee replacements and other surgeries, neither of which were statistically significantly higher. Opioid dose was also lower for all groups except MED was slightly higher for knee revisions (1.1 mg, P = 0.8; Fig. 2)’.
A number of errors were noted in Table 1. Table 1 should appear as above.
Table 1.
Demographic characteristics of orthopedic surgery patients, comparing IV acetaminophen (Ofirmev) recipients to IV opioid monotherapy recipients
| Characteristic | IV opioids (n = 311,090) | IV acetaminophen (n = 174,805) |
|---|---|---|
| Age (years), mean (SD) | 64.3 (15.6) | 63.6 (14.0) |
| Female, n (%) | 179,779 (57.8) | 102,864 (58.8) |
| Race, n (%) | ||
| White | 238,421 (76.6) | 140,748 (80.5) |
| Black | 24,876 (8.0) | 14,591 (8.4) |
| Hispanic | 47,600 (15.3) | 19,362 (11.1) |
| Unknown | 193 (0.1) | 104 (0.1) |
| APR-DRG severity of illness, n (%) | ||
| Minor | 136,264 (43.8) | 80,801 (46.2) |
| Moderate | 130,231 (41.9) | 77,862 (44.5) |
| Severe | 36,973 (11.9) | 14,462 (8.3) |
| Extreme | 7622 (2.5) | 1680 (1.0) |
| APR-DRG risk of mortality, n (%) | ||
| Minor | 217,279 (69.8) | 137,283 (78.5) |
| Moderate | 63,080 (20.3) | 28,648 (16.4) |
| Severe | 24,654 (7.9) | 7454 (4.3) |
| Extreme | 6077 (1.9) | 1420 (0.8) |
| Elective surgery, n (%) | 210,663 (67.7) | 136,318 (78.0) |
| Hospital region, n (%) | ||
| Midwest | 60,685 (19.5) | 27,639 (15.8) |
| Northeast | 70,154 (22.6) | 28,530 (16.3) |
| South | 132,013 (42.4) | 104,113 (59.6) |
| West | 48,238 (15.5) | 14,523 (8.3) |
| Surgery type, n (%) | ||
| Total knee replacement | 66,725 (21.4) | 64,399 (36.8) |
| Total hip replacement | 40,140 (12.9) | 33,541 (19.2) |
| Knee revision | 5187 (1.7) | 4869 (2.8) |
| Hip revision or partial replacement | 26,672 (8.6) | 9671 (5.5) |
| Fracture | 64,395 (20.7) | 17,928 (10.3) |
| Othera | 107,971 (34.7) | 44,397 (25.4) |
APR-DRG all patient refined-diagnosis related group, IV intravenous, SD standard deviation
aShoulder and spine
Furthermore, errors were noted in the field headings of Table 2. Table 2 should appear as above.
Table 2.
Unadjusted outcomes of orthopedic surgery patients, comparing IV acetaminophen recipients to IV opioid monotherapy recipients
| Outcome | IV opioids (n = 311,090) | IV acetaminophen (n = 174,805) | Difference (95% CI) | P value |
|---|---|---|---|---|
| Length of stay (days), mean (SD) | 3.9 (3.9) | 3.2 (2.6) | −0.66 (−0.68 to −0.64) | <0.0001 |
| Hospitalization cost ($), mean (SD) | 19,927.6 (19,578.8) | 19,024.9 (13,113.7) | −902.7 (−1005.4 to −800.0) | <0.0001 |
| Morphine equivalent dose (mg), mean (SD) | 43.8 (53.4) | 46.9 (44.5) | 3.1 (2.8 to 3.4) | <0.0001 |
| Opioid-related AEs, ORa (95% CI) | ||||
| Urinary tract infection | 0.596 (0.56 to 0.63) | <0.0001 | ||
| Respiratory depression | 0.518 (0.50 to 0.54) | <0.0001 | ||
| Surgery site infection | 0.754 (0.71 to 0.80) | <0.0001 | ||
| Bowel obstruction | 1.013 (0.99 to 1.04) | 0.4 | ||
| Nausea/vomiting | 1.208 (1.16 to 1.26) | <0.0001 | ||
AE adverse event, CI confidence interval, OR odds ratio, IV intravenous, SD standard deviation
aIV opioid monotherapy is the reference group
Open Access
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Footnotes
The online version of the original article can be found under doi:10.1007/s12325-016-0368-8.