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. Author manuscript; available in PMC: 2016 Sep 13.
Published in final edited form as: Stroke. 2014 Oct 28;45(12):3754–3832. doi: 10.1161/STR.0000000000000046

Table 4.

Odds ratios of intracranial hemorrhage relative to warfarin with an INR of 2.0 to 3.0

Drug Dose(s) OR (95% CI) Reference
Apixaban 5 mg twice daily 0.42 (0.30 to 0.58) Granger402
2.5 or 5 mg twice daily 0.17 (0.01 to 4.30) Ogawa321
Dabigatran 110 to 150 mg twice daily 0.36 (0.26 to 0.49) Connolly392
Rivaroxaban 20 mg daily 0.65 (0.46 to 0.92) Patel397
15 mg daily 0.50 (0.17 to 1.46) Hori394

CI indicates confidence interval; INR, international normalized ratio; and OR, odds ratio. Adapted with permission from Chatterjee et al.411 Copyright © 2013, American Medical Association. All rights reserved. Authorization for this adaptation has been obtained both from the owner of the copyright in the original work and from the owner of copyright in the translation or adaptation.