Abstract
AIMS--To evaluate the ability of histopathologists to classify lung carcinomas on bronchial biopsy material using the current World Health Organisation (WHO) classification. METHODS--Eleven histopathologists each reviewed 100 randomly selected bronchial biopsy specimens which had originally been reported as showing lung carcinoma. A single haematoxylin and eosin stained section from each case was circulated and a standard proforma completed. These were analysed using kappa statistics. RESULTS--The histopathologists were excellent at distinguishing between small cell and non-small-cell carcinoma kappa = 0.86), but not so good at subclassifying the non-small cell carcinoma group kappa = 0.25). CONCLUSIONS--The clinically important distinction between small cell and non-small cell carcinoma of the lung is reliably made by competent histopathologists even on limited material.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Chuang M. T., Marchevsky A., Teirstein A. S., Kirschner P. A., Kleinerman J. Diagnosis of lung cancer by fibreoptic bronchoscopy: problems in the histological classification of non-small cell carcinomas. Thorax. 1984 Mar;39(3):175–178. doi: 10.1136/thx.39.3.175. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Robertson A. J., Anderson J. M., Beck J. S., Burnett R. A., Howatson S. R., Lee F. D., Lessells A. M., McLaren K. M., Moss S. M., Simpson J. G. Observer variability in histopathological reporting of cervical biopsy specimens. J Clin Pathol. 1989 Mar;42(3):231–238. doi: 10.1136/jcp.42.3.231. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Robertson A. J., Beck J. S., Burnett R. A., Howatson S. R., Lee F. D., Lessells A. M., McLaren K. M., Moss S. M., Simpson J. G., Smith G. D. Observer variability in histopathological reporting of transitional cell carcinoma and epithelial dysplasia in bladders. J Clin Pathol. 1990 Jan;43(1):17–21. doi: 10.1136/jcp.43.1.17. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Roggli V. L., Vollmer R. T., Greenberg S. D., McGavran M. H., Spjut H. J., Yesner R. Lung cancer heterogeneity: a blinded and randomized study of 100 consecutive cases. Hum Pathol. 1985 Jun;16(6):569–579. doi: 10.1016/s0046-8177(85)80106-4. [DOI] [PubMed] [Google Scholar]