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. 1994 Oct;47(10):956–958. doi: 10.1136/jcp.47.10.956

Imerslund-Grasbeck syndrome in a Chinese family with distinct skin lesions refractory to vitamin B12.

S H Lin 1, N A Sourial 1, K C Lu 1, E J Hsueh 1
PMCID: PMC502184  PMID: 7962612

Abstract

Two brothers in a Chinese family with selective malabsorption of vitamin B12 associated with proteinuria (Imerslund-Grasbeck syndrome) presented with widespread mottled skin pigmentation, termed poikiloderma. In contrast to anaemia, this pigmentary disturbance remained unresponsive to vitamin B12 replacement. This is different from the reported hyperpigmentation sometimes seen in vitamin B12 deficiency which is reversible following treatment. As far as is known, an irreversible and persistent skin disorder has not been reported in this syndrome before.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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