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. 1990 Jan;43(1):13–16. doi: 10.1136/jcp.43.1.13

Paraganglial cells of urinary bladder and prostate: potential diagnostic problem.

J Rode 1, A Bentley 1, C Parkinson 1
PMCID: PMC502216  PMID: 1690221

Abstract

A transurethral prostatic resection for prostatism in a 73 year old man showed a cluster of richly capillarised clear cells originally thought to be indicative of invasive carcinoma. Immunohistochemical studies were carried out on this tissue specimen and three similar cases using a variety of antibodies--Neuron specific enolase, PGP 9.5, chromogranin, synaptophysin, serotonin, somatostatin, substance P, calcitonin, calcitonin gene related peptide, met-enkephalin, VIP, neurofilament, CAM 5.2, S100 protein, prostatic specific antigen and prostatic acid phosphatase. The cellular foci were shown to be composed of paraganglionic cells. The cell clusters were well defined and predominantly comprised clear cells with scanty, fine eosinophilic cytoplasmic granules in three cases. The cell nuclei were round to oval, moderately pleomorphic, with evenly dispersed dense chromatin. It is concluded that the presence of minute foci of paraganglial cells in the bladder wall and prostate gland may be misinterpreted as malignant because of their close association with nerves and their relative rarity. Immunohistochemical staining with neuroendocrine markers should dispel any doubt about their identity.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bains R. M., Miller K. D. Peroxidase labelling in immunocytochemistry: a critical comparison of five systems. Med Lab Sci. 1988 Jul;45(3):240–244. [PubMed] [Google Scholar]
  2. COUPLAND R. E. Post-natal fate of the abdominal para-aortic bodies in man. J Anat. 1954 Oct;88(4):455–464. [PMC free article] [PubMed] [Google Scholar]
  3. Gosling J. A., Thompson S. A. A neurohistochemical and histological study of peripheral autonomic neurons of the human bladder neck and prostate. Urol Int. 1977;32(4):269–276. doi: 10.1159/000280142. [DOI] [PubMed] [Google Scholar]
  4. Leestma J. E., Price E. B., Jr Paraganglioma of the urinary bladder. Cancer. 1971 Oct;28(4):1063–1073. doi: 10.1002/1097-0142(1971)28:4<1063::aid-cncr2820280433>3.0.co;2-r. [DOI] [PubMed] [Google Scholar]
  5. Lloyd R. V., Shapiro B., Sisson J. C., Kalff V., Thompson N. W., Beierwaltes W. A. An immunohistochemical study of pheochromocytomas. Arch Pathol Lab Med. 1984 Jul;108(7):541–544. [PubMed] [Google Scholar]
  6. Osamura R. Y., Tsutsumi Y., Yanaihara N., Imura H., Watanabe K. Immunohistochemical studies for multiple peptide-immunoreactivities and co-localization of Met-enkephalin-Arg6-Gly7-Leu8, neuropeptide Y and somatostatin in human adrenal medulla and pheochromocytomas. Peptides. 1987 Jan-Feb;8(1):77–87. doi: 10.1016/0196-9781(87)90168-9. [DOI] [PubMed] [Google Scholar]
  7. SCOTT W. W., EVERSOLE S. L. Pheochromocytoma of the urinary bladder. J Urol. 1960 May;83:656–664. doi: 10.1016/s0022-5347(17)65772-0. [DOI] [PubMed] [Google Scholar]
  8. Schulman C. C., Duarte-Escalante O., Boyarsky S. The ureterovesical innervation. A new concept based on a histochemical study. Br J Urol. 1972 Dec;44(6):698–712. doi: 10.1111/j.1464-410x.1972.tb10144.x. [DOI] [PubMed] [Google Scholar]
  9. Srigley J. R. Small-acinar patterns in the prostate gland with emphasis on atypical adenomatous hyperplasia and small-acinar carcinoma. Semin Diagn Pathol. 1988 Aug;5(3):254–272. [PubMed] [Google Scholar]
  10. ZIMMERMAN I. J., BIRON R. E., MACMAHON H. E. Pheochromocytoma of the urinary bladder. N Engl J Med. 1953 Jul 2;249(1):25–26. doi: 10.1056/NEJM195307022490106. [DOI] [PubMed] [Google Scholar]

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