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. 1990 Jan;43(1):17–21. doi: 10.1136/jcp.43.1.17

Observer variability in histopathological reporting of transitional cell carcinoma and epithelial dysplasia in bladders.

A J Robertson 1, J S Beck 1, R A Burnett 1, S R Howatson 1, F D Lee 1, A M Lessells 1, K M McLaren 1, S M Moss 1, J G Simpson 1, G D Smith 1, et al.
PMCID: PMC502217  PMID: 2312745

Abstract

Sections from 90 urinary bladder biopsy specimens were examined by 11 consultant histopathologists with varying experience to determine the appropriateness of existing pathology terminology. Analysis with kappa statistics showed fair to good agreement in the grading and staging of transitional cell carcinoma. There was also reasonable agreement in the diagnosis of high grade dysplasia in random biopsy specimens from the urothelium adjacent to the neoplasm, but very poor agreement for lesser degrees of dysplasia. It is concluded that the present classification of bladder carcinomata is reliable and that pathologists can determine stage with a high degree of reproducibility and grade with a fair degree of reproducibility.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Beck J. S. Observer variability in reporting of breast lesions. J Clin Pathol. 1985 Dec;38(12):1358–1365. doi: 10.1136/jcp.38.12.1358. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Bergkvist A., Ljungqvist A., Moberger G. Classification of bladder tumours based on the cellular pattern. Preliminary report of a clinical-pathological study of 300 cases with a minimum follow-up of eight years. Acta Chir Scand. 1965 Oct;130(4):371–378. [PubMed] [Google Scholar]
  3. Blomjous C. E., Schipper N. W., Baak J. P., van Galen E. M., de Voogt H. J., Meyer C. J. Retrospective study of prognostic importance of DNA flow cytometry of urinary bladder carcinoma. J Clin Pathol. 1988 Jan;41(1):21–25. doi: 10.1136/jcp.41.1.21. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Busch C., Engberg A., Norlén B. J., Stenkvist B. Malignancy grading of epithelial bladder tumours. Reproducibility of grading and comparison between forceps biopsy, aspiration biopsy and exfoliative cytology. Scand J Urol Nephrol. 1977;11(2):143–148. doi: 10.3109/00365597709179707. [DOI] [PubMed] [Google Scholar]
  5. Higgins G. A., Jr, Amadeo J. H., McElhinney J., McCaughan J. J., Keehn R. J. Efficacy of prolonged intermittent therapy with combined 5-fluorouracil and methyl-CCNU following resection for carcinoma of the large bowel. A Veterans Administration Surgical Oncology Group report. Cancer. 1984 Jan 1;53(1):1–8. doi: 10.1002/1097-0142(19840101)53:1<1::aid-cncr2820530102>3.0.co;2-l. [DOI] [PubMed] [Google Scholar]
  6. Landis J. R., Koch G. G. The measurement of observer agreement for categorical data. Biometrics. 1977 Mar;33(1):159–174. [PubMed] [Google Scholar]
  7. Lee F. D., Burnett R. A. Quality assurance in histopathology. J Pathol. 1987 Aug;152(4):247–251. doi: 10.1002/path.1711520402. [DOI] [PubMed] [Google Scholar]
  8. Murphy W. M., Soloway M. S. Developing carcinoma (dysplasia) of the urinary bladder. Pathol Annu. 1982;17(Pt 1):197–217. [PubMed] [Google Scholar]
  9. Nagy G. K., Frable W. J., Murphy W. M. Classification of premalignant urothelial abnormalities. A Delphi study of the National Bladder Cancer Collaborative Group A. Pathol Annu. 1982;17(Pt 1):219–233. [PubMed] [Google Scholar]
  10. Ooms E. C., Anderson W. A., Alons C. L., Boon M. E., Veldhuizen R. W. Analysis of the performance of pathologists in the grading of bladder tumors. Hum Pathol. 1983 Feb;14(2):140–143. doi: 10.1016/s0046-8177(83)80242-1. [DOI] [PubMed] [Google Scholar]
  11. Ooms E. C., Blok A. P., Veldhuizen R. W. The reproducibility of a quantitative grading system of bladder tumours. Histopathology. 1985 May;9(5):501–509. doi: 10.1111/j.1365-2559.1985.tb02831.x. [DOI] [PubMed] [Google Scholar]
  12. Ooms E. C., Kurver P. H., Veldhuizen R. W., Alons C. L., Boon M. E. Morphometric grading of bladder tumors in comparison with histologic grading by pathologists. Hum Pathol. 1983 Feb;14(2):144–150. doi: 10.1016/s0046-8177(83)80243-3. [DOI] [PubMed] [Google Scholar]
  13. Pagano F., Garbeglio A., Milani C., Bassi P., Pegoraro V. Prognosis of bladder cancer. I. Risk factors in superficial transitional cell carcinoma. Eur Urol. 1987;13(3):145–149. [PubMed] [Google Scholar]
  14. Pugh R. C. Proceedings: The pathology of cancer of the bladder. Cancer. 1973 Nov;32(5):1267–1274. doi: 10.1002/1097-0142(197311)32:5<1267::aid-cncr2820320536>3.0.co;2-6. [DOI] [PubMed] [Google Scholar]
  15. Robertson A. J., Anderson J. M., Beck J. S., Burnett R. A., Howatson S. R., Lee F. D., Lessells A. M., McLaren K. M., Moss S. M., Simpson J. G. Observer variability in histopathological reporting of cervical biopsy specimens. J Clin Pathol. 1989 Mar;42(3):231–238. doi: 10.1136/jcp.42.3.231. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Zuk R. J., Rogers H. S., Martin J. E., Baithun S. I. Clinicopathological importance of primary dysplasia of bladder. J Clin Pathol. 1988 Dec;41(12):1277–1280. doi: 10.1136/jcp.41.12.1277. [DOI] [PMC free article] [PubMed] [Google Scholar]

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