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. 1990 Jan;43(1):27–31. doi: 10.1136/jcp.43.1.27

Lamina propria eosinophils and mast cells in ulcerative colitis: comparison between Asians and Caucasians.

G F Benfield 1, R Bryan 1, J Crocker 1
PMCID: PMC502219  PMID: 2312747

Abstract

To investigate the theory of hypersensitivity in the colonic mucosa of Asian patients with ulcerative colitis the rectal biopsy specimens of Asian and Caucasian patients presenting with colitis were selectively stained for both eosinophils and mast cells. Comparisons between ethnic groups were made as well as the correlation to the blood eosinophil count and two variables of active ulcerative colitis--the blood leucocyte count and serum orosomucoid concentration. No correlation was found in either group between circulating and tissue eosinophils and no ethnic difference was identified in the lamina propria differential cell densities. The leucocyte count and serum orosomucoid concentrations, however, were significantly higher in the Caucasians. In the Asian group a strong negative association was found between the lamina propria eosinophil density and serum orosomucoids; in the Caucasian group there was a positive association between all blood variables. It is concluded that different mechanisms occur in the two ethnic groups and in Asians these might not be reflected by the more orthodox indices of colonic inflammation.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Benfield G. F., Asquith P. Blood eosinophilia and ulcerative colitis--influence of ethnic origin. Postgrad Med J. 1986 Dec;62(734):1101–1105. doi: 10.1136/pgmj.62.734.1101. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Bercovitz Z. T., Sommers S. C. Altered inflammatory reaction in nonspecific ulcerative colitis. Arch Intern Med. 1966 Apr;117(4):504–510. [PubMed] [Google Scholar]
  3. Binder V., Hvidberg E. Histamine content of rectal mucosa in ulcerative colitis. Gut. 1967 Feb;8(1):24–28. doi: 10.1136/gut.8.1.24. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Blaies D. M., Williams J. F. A simplified method for staining mast cells with astra blue. Stain Technol. 1981 Mar;56(2):91–94. doi: 10.3109/10520298109067288. [DOI] [PubMed] [Google Scholar]
  5. Heatley R. V., Calcraft B. J., Fifield R., Rhodes J., Whitehead R. H., Newcombe R. G. Immunoglobulin E in rectal mucosa of patients with proctitis. Lancet. 1975 Nov 22;2(7943):1010–1012. doi: 10.1016/s0140-6736(75)90294-9. [DOI] [PubMed] [Google Scholar]
  6. Heatley R. V., James P. D. Eosinophils in the rectal mucosa. A simple method of predicting the outcome of ulcerative proctocolitis? Gut. 1979 Sep;20(9):787–791. doi: 10.1136/gut.20.9.787. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Jensen K. B., Jarnum S., Koudahl G., Kristensen M. Serum orosomucoid in ulcerative colitis: its relation to clinical activity, protein loss, and turnover of albumin and IgG. Scand J Gastroenterol. 1976;11(2):177–183. [PubMed] [Google Scholar]
  8. Knoflach P., Park B. H., Cunningham R., Weiser M. M., Albini B. Serum antibodies to cow's milk proteins in ulcerative colitis and Crohn's disease. Gastroenterology. 1987 Feb;92(2):479–485. doi: 10.1016/0016-5085(87)90145-4. [DOI] [PubMed] [Google Scholar]
  9. Li C. Y., Yam L. T., Crosby W. H. Histochemical characterization of cellular and structural elements of the human spleen. J Histochem Cytochem. 1972 Dec;20(12):1049–1058. doi: 10.1177/20.12.1049. [DOI] [PubMed] [Google Scholar]
  10. Lloyd G., Green F. H., Fox H., Mani V., Turnberg L. A. Mast cells and immunoglobulin E in inflammatory bowel disease. Gut. 1975 Nov;16(11):861–865. doi: 10.1136/gut.16.11.861. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Marner I. L., Friborg S., Simonsen E. Disease activity and serum proteins in ulcerative colitis. Immunochemical quantitation. Scand J Gastroenterol. 1975;10(5):537–544. [PubMed] [Google Scholar]
  12. RIIS P., ANTHONISEN P. EOSINOPHILIA IN PERIPHERAL BLOOD AND INFLAMMATORY EXUDATE IN NON-SPECIFIC PROCTOCOLITIS. Acta Med Scand. 1964 Jan;175:85–89. doi: 10.1111/j.0954-6820.1964.tb00553.x. [DOI] [PubMed] [Google Scholar]
  13. Ranlöv P., Nielsen M. H., Wanstrup J. Ultrastructure of the ileum in Crohn's disease. Immune lesions and mastocytosis. Scand J Gastroenterol. 1972;7(5):471–476. doi: 10.3109/00365527209180772. [DOI] [PubMed] [Google Scholar]
  14. Sanderson I. R., Leung K. B., Pearce F. L., Walker-Smith J. A. Lamina propria mast cells in biopsies from children with Crohn's disease. J Clin Pathol. 1986 Mar;39(3):279–283. doi: 10.1136/jcp.39.3.279. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Wright R., Truelove S. C. Circulating and tissue eosinophils in ulcerative colitis. Am J Dig Dis. 1966 Nov;11(11):831–846. doi: 10.1007/BF02233940. [DOI] [PubMed] [Google Scholar]

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