Skip to main content
NCBI home page
Journal of Clinical Pathology logoLink to Journal of Clinical Pathology
. 1990 Jan;43(1):79–81. doi: 10.1136/jcp.43.1.79

Serological diagnosis of neurobrucellosis.

A Sanchez-Sousa 1, C Torres 1, M G Campello 1, C Garcia 1, F Parras 1, E Cercenado 1, F Baquero 1
PMCID: PMC502231  PMID: 2312754

Abstract

The presence of antibodies was determined in the serum and cerebrospinal fluid in six patients with neurobrucellosis using the Rose Bengal test, the microdilution agglutination test, and the Coombs' test. Four of the patients were followed up for more than three months. The Rose Bengal test and the microagglutination test were positive in cerebrospinal fluid in five of the six cases at some stage. The Coombs' test was positive in cerebrospinal fluid in every patient and in one was the only positive serological test. Cerebrospinal fluid positivity is not excluded by low titres or negative results of antibodies in the serum for any of the three methods. A Coombs' test or some equivalent must always be made on the cerebrospinal fluid to diagnose neurobrucellosis.

Full text

PDF
79

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Alapin B. Psychosomatic and somato-psychic aspects of brucellosis. J Psychosom Res. 1976;20(4):339–350. doi: 10.1016/0022-3999(76)90085-4. [DOI] [PubMed] [Google Scholar]
  2. Buades J., Obrador A., Massot B., Siquier B., Villalonga C., Cabrer B. Méningite brucellienne et test au rose Bengale. Nouv Presse Med. 1981 Feb 7;10(5):335–336. [PubMed] [Google Scholar]
  3. Colmenero J. de D., Valdivielso P., Camps M. T., Porras J. J., Trujillo J., Juárez C. Brucelosis: estudio clínico-epidemiológico de 139 casos. Med Clin (Barc) 1983 May 14;80(17):748–751. [PubMed] [Google Scholar]
  4. Dupont B., Bletry O., Tucat G., Veyssier P., Philippon A. M., Godeau P. Neurobrucelloses chroniques avec sérodiagnostic de Wright négatif. 2 observations. Nouv Presse Med. 1980 Oct 11;9(37):2721–2724. [PubMed] [Google Scholar]
  5. FINCHAM R. W., SAHS A. L., JOYNT R. J. Protean manifestations of nervous system brucellosis. Case histories of a wide variety of clinical forms. JAMA. 1963 Apr 27;184:269–275. doi: 10.1001/jama.1963.03700170061009. [DOI] [PubMed] [Google Scholar]
  6. Kerr W. R., McCaughey W. J., Coghlan J. D., Payne D. J., Quaife R. A., Robertson L., Farrell I. D. Techniques and interpretations in the serological diagnosis of brucellosis in man. J Med Microbiol. 1968 Nov;1(2):181–193. doi: 10.1099/00222615-1-2-181. [DOI] [PubMed] [Google Scholar]
  7. Larbrisseau A., Maravi E., Aguilera F., Martinez-Lage J. M. The neurological complications of brucellosis. Can J Neurol Sci. 1978 Nov;5(4):369–376. doi: 10.1017/s0317167100024124. [DOI] [PubMed] [Google Scholar]
  8. Morgan W. J., MacKinnon D. J., Lawson J. R., Cullen G. A. The rose bengal plate agglutination test in the diagnosis of brucellosis. Vet Rec. 1969 Dec 6;85(23):636–641. doi: 10.1136/vr.85.23.636. [DOI] [PubMed] [Google Scholar]
  9. Olmer J., Gabriel B., Luciani J. M. A propos des méningo-encéphalites brucellosiques. Mars Med. 1968;105(3):265–269. [PubMed] [Google Scholar]
  10. Parratt D., Nielsen K. H., White R. G. Radioimmunoassay of IgM, IgG, and IgA Brucella antibodies. Lancet. 1977 May 21;1(8021):1075–1078. doi: 10.1016/s0140-6736(77)92334-0. [DOI] [PubMed] [Google Scholar]
  11. Sanz Moreno J., Puras Tellaeche A., Alguacil Muñoz A., Alonso Navas F., Franch O., Damiano Rivero A. Neurobrucelosis. Rev Clin Esp. 1985 Apr;176(7):349–353. [PubMed] [Google Scholar]
  12. Wise R. I. Brucellosis in the United States. Past, present, and future. JAMA. 1980 Nov 21;244(20):2318–2322. [PubMed] [Google Scholar]

Articles from Journal of Clinical Pathology are provided here courtesy of BMJ Publishing Group

RESOURCES