Skip to main content
NCBI home page
Journal of Clinical Pathology logoLink to Journal of Clinical Pathology
. 1990 Mar;43(3):184–192. doi: 10.1136/jcp.43.3.184

Review: assessment of cell proliferation in histological material.

P A Hall 1, D A Levison 1
PMCID: PMC502326  PMID: 2185282

Full text

PDF
184

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Akerman M., Brandt L., Johnson A., Olsson H. Mitotic activity in non-Hodgkin's lymphoma. Relation to the Kiel classification and to prognosis. Br J Cancer. 1987 Feb;55(2):219–223. doi: 10.1038/bjc.1987.41. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Baisch H., Beck H. P., Christensen I. J., Hartmann N. R., Fried J., Dean P. N., Gray J. W., Jett J. H., Johnston D. A., White R. A. A comparison of mathematical methods for the analysis of DNA histograms obtained by flow cytometry. Cell Tissue Kinet. 1982 May;15(3):235–249. doi: 10.1111/j.1365-2184.1982.tb01043.x. [DOI] [PubMed] [Google Scholar]
  3. Baisch H., Gerdes J. Simultaneous staining of exponentially growing versus plateau phase cells with the proliferation-associated antibody Ki-67 and propidium iodide: analysis by flow cytometry. Cell Tissue Kinet. 1987 Jul;20(4):387–391. doi: 10.1111/j.1365-2184.1987.tb01323.x. [DOI] [PubMed] [Google Scholar]
  4. Barnard N. J., Hall P. A., Lemoine N. R., Kadar N. Proliferative index in breast carcinoma determined in situ by Ki67 immunostaining and its relationship to clinical and pathological variables. J Pathol. 1987 Aug;152(4):287–295. doi: 10.1002/path.1711520407. [DOI] [PubMed] [Google Scholar]
  5. Bauer K. D., Merkel D. E., Winter J. N., Marder R. J., Hauck W. W., Wallemark C. B., Williams T. J., Variakojis D. Prognostic implications of ploidy and proliferative activity in diffuse large cell lymphomas. Cancer Res. 1986 Jun;46(6):3173–3178. [PubMed] [Google Scholar]
  6. Bensch K. G., Tanaka S., Hu S. Z., Wang T. S., Korn D. Intracellular localization of human DNA polymerase alpha with monoclonal antibodies. J Biol Chem. 1982 Jul 25;257(14):8391–8396. [PubMed] [Google Scholar]
  7. Bouzubar N., Walker K. J., Griffiths K., Ellis I. O., Elston C. W., Robertson J. F., Blamey R. W., Nicholson R. I. Ki67 immunostaining in primary breast cancer: pathological and clinical associations. Br J Cancer. 1989 Jun;59(6):943–947. doi: 10.1038/bjc.1989.200. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Brandt L., Olsson H., Monti M. Uptake of thymidine in lymphoma cells obtained through fine-needle aspiration biopsy. Relation to prognosis in non-Hodgkin's lymphomas. Eur J Cancer Clin Oncol. 1981 Nov;17(11):1229–1233. [PubMed] [Google Scholar]
  9. Bravo R., Frank R., Blundell P. A., Macdonald-Bravo H. Cyclin/PCNA is the auxiliary protein of DNA polymerase-delta. Nature. 1987 Apr 2;326(6112):515–517. doi: 10.1038/326515a0. [DOI] [PubMed] [Google Scholar]
  10. Braylan R. C., Diamond L. W., Powell M. L., Harty-Golder B. Percentage of cells in the S phase of the cell cycle in human lymphoma determined by flow cytometry. Cytometry. 1980 Nov;1(3):171–174. doi: 10.1002/cyto.990010302. [DOI] [PubMed] [Google Scholar]
  11. Breeden L. Cell cycle-regulated promoters in budding yeast. Trends Genet. 1988 Sep;4(9):249–253. doi: 10.1016/0168-9525(88)90031-5. [DOI] [PubMed] [Google Scholar]
  12. Brown D. C., Cole D., Gatter K. C., Mason D. Y. Carcinoma of the cervix uteri: an assessment of tumour proliferation using the monoclonal antibody Ki67. Br J Cancer. 1988 Feb;57(2):178–181. doi: 10.1038/bjc.1988.37. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Brown D. C., Gatter K. C., Dunnill M. S., Mason D. Y. Immunocytochemical analysis of cytocentrifuged fine needle aspirates. A study based on lung tumors aspirated in vitro. Anal Quant Cytol Histol. 1989 Apr;11(2):140–145. [PubMed] [Google Scholar]
  14. Buick R. N., Pollak M. N. Perspectives on clonogenic tumor cells, stem cells, and oncogenes. Cancer Res. 1984 Nov;44(11):4909–4918. [PubMed] [Google Scholar]
  15. Burger P. C., Shibata T., Kleihues P. The use of the monoclonal antibody Ki-67 in the identification of proliferating cells: application to surgical neuropathology. Am J Surg Pathol. 1986 Sep;10(9):611–617. doi: 10.1097/00000478-198609000-00003. [DOI] [PubMed] [Google Scholar]
  16. Camplejohn R. S., Macartney J. C., Morris R. W. Measurement of S-phase fractions in lymphoid tissue comparing fresh versus paraffin-embedded tissue and 4',6'-diamidino-2 phenylindole dihydrochloride versus propidium iodide staining. Cytometry. 1989 Jul;10(4):410–416. doi: 10.1002/cyto.990100408. [DOI] [PubMed] [Google Scholar]
  17. Celis J. E., Bravo R., Larsen P. M., Fey S. J. Cyclin: a nuclear protein whose level correlates directly with the proliferative state of normal as well as transformed cells. Leuk Res. 1984;8(2):143–157. doi: 10.1016/0145-2126(84)90135-8. [DOI] [PubMed] [Google Scholar]
  18. Charpin C., Andrac L., Habib M. C., Vacheret H., Xerri L., Devictor B., Lavaut M. N., Toga M. Immunodetection in fine-needle aspirates and multiparametric (SAMBA) image analysis. Receptors (monoclonal antiestrogen and antiprogesterone) and growth fraction (monoclonal Ki67) evaluation in breast carcinomas. Cancer. 1989 Mar 1;63(5):863–872. doi: 10.1002/1097-0142(19890301)63:5<863::aid-cncr2820630512>3.0.co;2-p. [DOI] [PubMed] [Google Scholar]
  19. Chilosi M., Menestrina F., Capelli P., Montagna L., Lestani M., Pizzolo G., Cipriani A., Agostini C., Trentin L., Zambello R. Immunohistochemical analysis of sarcoid granulomas. Evaluation of Ki67+ and interleukin-1+ cells. Am J Pathol. 1988 May;131(2):191–198. [PMC free article] [PubMed] [Google Scholar]
  20. Cibull M. L., Heryet A., Gatter K. C., Mason D. Y. The utility of Ki67 immunostaining, nuclear organizer region counting, and morphology in the assessment of follicular lymphomas. J Pathol. 1989 Jul;158(3):189–193. doi: 10.1002/path.1711580304. [DOI] [PubMed] [Google Scholar]
  21. Cooper E. H., Peckham M. J., Millard R. E., Hamlin I. M., Gérard-Marchant R. Cell proliferation in human malignant lymphomas. Analysis of labelling index and DNA content in cell populations obtained by biopsy. Eur J Cancer. 1968 Jul;4(3):287–296. doi: 10.1016/0014-2964(68)90054-6. [DOI] [PubMed] [Google Scholar]
  22. Costa A., Bonadonna G., Villa E., Valagussa P., Silvestrini R. Labeling index as a prognostic marker in non-Hodgkin's lymphomas. J Natl Cancer Inst. 1981 Jan;66(1):1–5. [PubMed] [Google Scholar]
  23. Crocker J., Ayres J., McGovern J. Nucleolar organiser regions in small cell carcinoma of the bronchus. Thorax. 1987 Dec;42(12):972–975. doi: 10.1136/thx.42.12.972. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Crocker J., Macartney J. C., Smith P. J. Correlation between DNA flow cytometric and nucleolar organizer region data in non-Hodgkin's lymphomas. J Pathol. 1988 Feb;154(2):151–156. doi: 10.1002/path.1711540207. [DOI] [PubMed] [Google Scholar]
  25. Crocker J., Nar P. Nucleolar organizer regions in lymphomas. J Pathol. 1987 Feb;151(2):111–118. doi: 10.1002/path.1711510203. [DOI] [PubMed] [Google Scholar]
  26. Crocker J., Skilbeck N. Nucleolar organiser region associated proteins in cutaneous melanotic lesions: a quantitative study. J Clin Pathol. 1987 Aug;40(8):885–889. doi: 10.1136/jcp.40.8.885. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. Das B. C., Rani R., Mitra A. B., Luthra U. K. The number of silver-staining NORs (rDNA) in lymphocytes of newborns and its relationship to human development. Mech Ageing Dev. 1986 Oct;36(2):117–123. doi: 10.1016/0047-6374(86)90012-6. [DOI] [PubMed] [Google Scholar]
  28. Dean P. N., Dolbeare F., Gratzner H., Rice G. C., Gray J. W. Cell-cycle analysis using a monoclonal antibody to BrdUrd. Cell Tissue Kinet. 1984 Jul;17(4):427–436. doi: 10.1111/j.1365-2184.1984.tb00601.x. [DOI] [PubMed] [Google Scholar]
  29. Derenzini M., Pession A., Farabegoli F., Trerè D., Badiali M., Dehan P. Relationship between interphasic nucleolar organizer regions and growth rate in two neuroblastoma cell lines. Am J Pathol. 1989 Apr;134(4):925–932. [PMC free article] [PubMed] [Google Scholar]
  30. Diamond L. W., Nathwani B. N., Rappaport H. Flow cytometry in the diagnosis and classification of malignant lymphoma and leukemia. Cancer. 1982 Sep 15;50(6):1122–1135. doi: 10.1002/1097-0142(19820915)50:6<1122::aid-cncr2820500616>3.0.co;2-q. [DOI] [PubMed] [Google Scholar]
  31. Dolbeare F., Gratzner H., Pallavicini M. G., Gray J. W. Flow cytometric measurement of total DNA content and incorporated bromodeoxyuridine. Proc Natl Acad Sci U S A. 1983 Sep;80(18):5573–5577. doi: 10.1073/pnas.80.18.5573. [DOI] [PMC free article] [PubMed] [Google Scholar]
  32. Draetta G., Beach D. Activation of cdc2 protein kinase during mitosis in human cells: cell cycle-dependent phosphorylation and subunit rearrangement. Cell. 1988 Jul 1;54(1):17–26. doi: 10.1016/0092-8674(88)90175-4. [DOI] [PubMed] [Google Scholar]
  33. Draetta G., Brizuela L., Potashkin J., Beach D. Identification of p34 and p13, human homologs of the cell cycle regulators of fission yeast encoded by cdc2+ and suc1+. Cell. 1987 Jul 17;50(2):319–325. doi: 10.1016/0092-8674(87)90227-3. [DOI] [PubMed] [Google Scholar]
  34. Dunphy W. G., Newport J. W. Unraveling of mitotic control mechanisms. Cell. 1988 Dec 23;55(6):925–928. doi: 10.1016/0092-8674(88)90234-6. [DOI] [PubMed] [Google Scholar]
  35. Egan M. J., Raafat F., Crocker J., Smith K. Nucleolar organizer regions in small cell tumours of childhood. J Pathol. 1987 Nov;153(3):275–280. doi: 10.1002/path.1711530312. [DOI] [PubMed] [Google Scholar]
  36. Egan M., Raafat F., Crocker J., Williams D. Comparative study of the degree of differentiation of neuroblastoma and mean numbers of nucleolar organiser regions. J Clin Pathol. 1988 May;41(5):527–531. doi: 10.1136/jcp.41.5.527. [DOI] [PMC free article] [PubMed] [Google Scholar]
  37. Egerter D. A., Said J. W., Epling S., Lee S. DNA content of T-cell lymphomas. A flow-cytometric analysis. Am J Pathol. 1988 Feb;130(2):326–334. [PMC free article] [PubMed] [Google Scholar]
  38. Elliott C. J., Sloane J. P., Pallett C. D., Sanderson K. V. Cutaneous leucocyte composition after human allogeneic bone marrow transplantation: relationship to marrow purging, histology and clinical rash. Histopathology. 1988 Jan;12(1):1–16. doi: 10.1111/j.1365-2559.1988.tb01912.x. [DOI] [PubMed] [Google Scholar]
  39. Ellis P. S., Whitehead R. Mitosis counting--a need for reappraisal. Hum Pathol. 1981 Jan;12(1):3–4. doi: 10.1016/s0046-8177(81)80235-3. [DOI] [PubMed] [Google Scholar]
  40. Ellison D. J., Nathwani B. N., Metter G. E., Turner R. R., Burke J. S., Miller T. P., Mann R. B., Barcos M., Kjeldsberg C. R., Winberg C. D. Mitotic counts in follicular lymphomas. Hum Pathol. 1987 May;18(5):502–505. doi: 10.1016/s0046-8177(87)80035-7. [DOI] [PubMed] [Google Scholar]
  41. Falini B., Canino S., Sacchi S., Ciani C., Martelli M. F., Gerdes J., Stein H., Pileri S., Gobbi M., Fagioli M. Immunocytochemical evaluation of the percentage of proliferating cells in pathological bone marrow and peripheral blood samples with the Ki-67 and anti-bromo-deoxyuridine monoclonal antibodies. Br J Haematol. 1988 Jul;69(3):311–320. doi: 10.1111/j.1365-2141.1988.tb02368.x. [DOI] [PubMed] [Google Scholar]
  42. Falini B., Stein H., Pileri S., Canino S., Farabbi R., Martelli M. F., Grignani F., Fagioli M., Minelli O., Ciani C. Expression of lymphoid-associated antigens on Hodgkin's and Reed-Sternberg cells of Hodgkin's disease. An immunocytochemical study on lymph node cytospins using monoclonal antibodies. Histopathology. 1987 Dec;11(12):1229–1242. doi: 10.1111/j.1365-2559.1987.tb01869.x. [DOI] [PubMed] [Google Scholar]
  43. Fallowfield M. E., Cook M. G. The value of nucleolar organizer region staining in the differential diagnosis of borderline melanocytic lesions. Histopathology. 1989 Mar;14(3):299–304. doi: 10.1111/j.1365-2559.1989.tb02148.x. [DOI] [PubMed] [Google Scholar]
  44. Field D. H., Fitzgerald P. H., Sin F. Y. Nucleolar silver-staining patterns related to cell cycle phase and cell generation of PHA-stimulated human lymphocytes. Cytobios. 1984;41(161):23–33. [PubMed] [Google Scholar]
  45. Franklin W. A., Bibbo M., Doria M. I., Dytch H. E., Toth J., DeSombre E., Wied G. L. Quantitation of estrogen receptor content and Ki-67 staining in breast carcinoma by the microTICAS image analysis system. Anal Quant Cytol Histol. 1987 Aug;9(4):279–286. [PubMed] [Google Scholar]
  46. Franklin W. A., McDonald G. B., Stein H. O., Gatter K. C., Jewell D. P., Clarke L. C., Mason D. Y. Immunohistologic demonstration of abnormal colonic crypt cell kinetics in ulcerative colitis. Hum Pathol. 1985 Nov;16(11):1129–1132. doi: 10.1016/s0046-8177(85)80181-7. [DOI] [PubMed] [Google Scholar]
  47. Friedlander M. L., Hedley D. W., Taylor I. W. Clinical and biological significance of aneuploidy in human tumours. J Clin Pathol. 1984 Sep;37(9):961–974. doi: 10.1136/jcp.37.9.961. [DOI] [PMC free article] [PubMed] [Google Scholar]
  48. Garcia C. F., Weiss L. M., Lowder J., Komoroske C., Link M. P., Levy R., Warnke R. A. Quantitation and estimation of lymphocyte subsets in tissue sections. Comparison with flow cytometry. Am J Clin Pathol. 1987 Apr;87(4):470–477. doi: 10.1093/ajcp/87.4.470. [DOI] [PubMed] [Google Scholar]
  49. Garcia R. L., Coltrera M. D., Gown A. M. Analysis of proliferative grade using anti-PCNA/cyclin monoclonal antibodies in fixed, embedded tissues. Comparison with flow cytometric analysis. Am J Pathol. 1989 Apr;134(4):733–739. [PMC free article] [PubMed] [Google Scholar]
  50. Gatter K. C., Brown G., Trowbridge I. S., Woolston R. E., Mason D. Y. Transferrin receptors in human tissues: their distribution and possible clinical relevance. J Clin Pathol. 1983 May;36(5):539–545. doi: 10.1136/jcp.36.5.539. [DOI] [PMC free article] [PubMed] [Google Scholar]
  51. Gatter K. C., Dunnill M. S., Gerdes J., Stein H., Mason D. Y. New approach to assessing lung tumours in man. J Clin Pathol. 1986 Jun;39(6):590–593. doi: 10.1136/jcp.39.6.590. [DOI] [PMC free article] [PubMed] [Google Scholar]
  52. Gentili C., Sanfilippo O., Silvestrini R. Cell proliferation and its relationship to clinical features and relapse in breast cancers. Cancer. 1981 Aug 15;48(4):974–979. doi: 10.1002/1097-0142(19810815)48:4<974::aid-cncr2820480420>3.0.co;2-#. [DOI] [PubMed] [Google Scholar]
  53. Gerdes J., Dallenbach F., Lennert K., Lemke H., Stein H. Growth fractions in malignant non-Hodgkin's lymphomas (NHL) as determined in situ with the monoclonal antibody Ki-67. Hematol Oncol. 1984 Oct-Dec;2(4):365–371. doi: 10.1002/hon.2900020406. [DOI] [PubMed] [Google Scholar]
  54. Gerdes J., Lelle R. J., Pickartz H., Heidenreich W., Schwarting R., Kurtsiefer L., Stauch G., Stein H. Growth fractions in breast cancers determined in situ with monoclonal antibody Ki-67. J Clin Pathol. 1986 Sep;39(9):977–980. doi: 10.1136/jcp.39.9.977. [DOI] [PMC free article] [PubMed] [Google Scholar]
  55. Gerdes J., Lemke H., Baisch H., Wacker H. H., Schwab U., Stein H. Cell cycle analysis of a cell proliferation-associated human nuclear antigen defined by the monoclonal antibody Ki-67. J Immunol. 1984 Oct;133(4):1710–1715. [PubMed] [Google Scholar]
  56. Gerdes J., Schwab U., Lemke H., Stein H. Production of a mouse monoclonal antibody reactive with a human nuclear antigen associated with cell proliferation. Int J Cancer. 1983 Jan 15;31(1):13–20. doi: 10.1002/ijc.2910310104. [DOI] [PubMed] [Google Scholar]
  57. Gerdes J., Schwarting R., Stein H. High proliferative activity of Reed Sternberg associated antigen Ki-1 positive cells in normal lymphoid tissue. J Clin Pathol. 1986 Sep;39(9):993–997. doi: 10.1136/jcp.39.9.993. [DOI] [PMC free article] [PubMed] [Google Scholar]
  58. Gerdes J., Stein H., Pileri S., Rivano M. T., Gobbi M., Ralfkiaer E., Nielsen K. M., Pallesen G., Bartels H., Palestro G. Prognostic relevance of tumour-cell growth fraction in malignant non-Hodgkin's lymphomas. Lancet. 1987 Aug 22;2(8556):448–449. doi: 10.1016/s0140-6736(87)90977-9. [DOI] [PubMed] [Google Scholar]
  59. Gerdes J., Van Baarlen J., Pileri S., Schwarting R., Van Unnik J. A., Stein H. Tumor cell growth fraction in Hodgkin's disease. Am J Pathol. 1987 Sep;128(3):390–393. [PMC free article] [PubMed] [Google Scholar]
  60. Giangaspero F., Doglioni C., Rivano M. T., Pileri S., Gerdes J., Stein H. Growth fraction in human brain tumors defined by the monoclonal antibody Ki-67. Acta Neuropathol. 1987;74(2):179–182. doi: 10.1007/BF00692849. [DOI] [PubMed] [Google Scholar]
  61. Graem N., Helweg-Larsen K. Mitotic activity and delay in fixation of tumour tissue. The influence of delay in fixation on mitotic activity of a human osteogenic sarcoma grown in athymic nude mice. Acta Pathol Microbiol Scand A. 1979 Sep;87A(5):375–378. [PubMed] [Google Scholar]
  62. Gratzner H. G. Monoclonal antibody to 5-bromo- and 5-iododeoxyuridine: A new reagent for detection of DNA replication. Science. 1982 Oct 29;218(4571):474–475. doi: 10.1126/science.7123245. [DOI] [PubMed] [Google Scholar]
  63. Griffin N. R., Howard M. R., Quirke P., O'Brien C. J., Child J. A., Bird C. C. Prognostic indicators in centroblastic-centrocytic lymphoma. J Clin Pathol. 1988 Aug;41(8):866–870. doi: 10.1136/jcp.41.8.866. [DOI] [PMC free article] [PubMed] [Google Scholar]
  64. Grigioni W. F., D'Errico A., Bacci F., Gaudio M., Mazziotti A., Gozzetti G., Mancini A. M. Primary liver neoplasms: evaluation of proliferative index using MoAb Ki67. J Pathol. 1989 May;158(1):23–29. doi: 10.1002/path.1711580107. [DOI] [PubMed] [Google Scholar]
  65. Grogan T. M., Lippman S. M., Spier C. M., Slymen D. J., Rybski J. A., Rangel C. S., Richter L. C., Miller T. P. Independent prognostic significance of a nuclear proliferation antigen in diffuse large cell lymphomas as determined by the monoclonal antibody Ki-67. Blood. 1988 Apr;71(4):1157–1160. [PubMed] [Google Scholar]
  66. Guillaud P., du Manoir S., Seigneurin D. Quantification and topographical description of Ki-67 antibody labelling during the cell cycle of normal fibroblastic (MRC-5) and mammary tumour cell lines (MCF-7). Anal Cell Pathol. 1989 Feb;1(1):25–39. [PubMed] [Google Scholar]
  67. Habeshaw J. A., Lister T. A., Stansfeld A. G., Greaves M. F. Correlation of transferrin receptor expression with histological class and outcome in non-Hodgkin lymphoma. Lancet. 1983 Mar 5;1(8323):498–501. doi: 10.1016/s0140-6736(83)92191-8. [DOI] [PubMed] [Google Scholar]
  68. Hall P. A., Crocker J., Watts A., Stansfeld A. G. A comparison of nucleolar organizer region staining and Ki-67 immunostaining in non-Hodgkin's lymphoma. Histopathology. 1988 Apr;12(4):373–381. doi: 10.1111/j.1365-2559.1988.tb01952.x. [DOI] [PubMed] [Google Scholar]
  69. Hall P. A., Greenwood R. A., d'Ardenne A. J., Levison D. A. In situ demonstration of renal tubular regeneration using the monoclonal antibody Ki67. Nephron. 1988;49(2):122–125. doi: 10.1159/000185037. [DOI] [PubMed] [Google Scholar]
  70. Hall P. A., Richards M. A., Gregory W. M., d'Ardenne A. J., Lister T. A., Stansfeld A. G. The prognostic value of Ki67 immunostaining in non-Hodgkin's lymphoma. J Pathol. 1988 Mar;154(3):223–235. doi: 10.1002/path.1711540305. [DOI] [PubMed] [Google Scholar]
  71. Hall P. A., Watt F. M. Stem cells: the generation and maintenance of cellular diversity. Development. 1989 Aug;106(4):619–633. doi: 10.1242/dev.106.4.619. [DOI] [PubMed] [Google Scholar]
  72. Hedley D. W., Friedlander M. L., Taylor I. W., Rugg C. A., Musgrove E. A. Method for analysis of cellular DNA content of paraffin-embedded pathological material using flow cytometry. J Histochem Cytochem. 1983 Nov;31(11):1333–1335. doi: 10.1177/31.11.6619538. [DOI] [PubMed] [Google Scholar]
  73. Hedley D. W., Rugg C. A., Gelber R. D. Association of DNA index and S-phase fraction with prognosis of nodes positive early breast cancer. Cancer Res. 1987 Sep 1;47(17):4729–4735. [PubMed] [Google Scholar]
  74. Hernandez-Verdun D., Derenzini M., Bouteille M. Relationship between the Ag-NOR proteins and ribosomal chromatin in situ during drug-induced RNA synthesis inhibition. J Ultrastruct Res. 1984 Jul;88(1):55–65. doi: 10.1016/s0022-5320(84)90181-3. [DOI] [PubMed] [Google Scholar]
  75. Jan-Mohamed R. M., Armstrong S. J., Crocker J., Leyland M. J., Hulten M. A. The relationship between number of interphase nors and nor-bearing chromosomes in non-Hodgkin's lymphoma. J Pathol. 1989 May;158(1):3–7. doi: 10.1002/path.1711580103. [DOI] [PubMed] [Google Scholar]
  76. Joensuu H., Klemi P. J., Eerola E. Diagnostic value of DNA flow cytometry combined with fine needle aspiration biopsy in lymphomas. J Pathol. 1988 Mar;154(3):237–245. doi: 10.1002/path.1711540306. [DOI] [PubMed] [Google Scholar]
  77. Joensuu H., Klemi P. J., Korkeila E. Prognostic value of DNA ploidy and proliferative activity in Hodgkin's disease. Am J Clin Pathol. 1988 Dec;90(6):670–673. doi: 10.1093/ajcp/90.6.670. [DOI] [PubMed] [Google Scholar]
  78. Juneja S. K., Cooper I. A., Hodgson G. S., Wolf M. M., Ding J. C., Ironside P. N., Thomas R. J., Parkin J. D. DNA ploidy patterns and cytokinetics of non-Hodgkin's lymphoma. J Clin Pathol. 1986 Sep;39(9):987–992. doi: 10.1136/jcp.39.9.987. [DOI] [PMC free article] [PubMed] [Google Scholar]
  79. Kaczmarek L. Protooncogene expression during the cell cycle. Lab Invest. 1986 Apr;54(4):365–376. [PubMed] [Google Scholar]
  80. Kamel O. W., Franklin W. A., Ringus J. C., Meyer J. S. Thymidine labeling index and Ki-67 growth fraction in lesions of the breast. Am J Pathol. 1989 Jan;134(1):107–113. [PMC free article] [PubMed] [Google Scholar]
  81. Kuenen-Boumeester V., Blonk D. I., Van der Kwast T. H. Immunocytochemical staining of proliferating cells in fine needle aspiration smears of primary and metastatic breast tumours. Br J Cancer. 1988 May;57(5):509–511. doi: 10.1038/bjc.1988.115. [DOI] [PMC free article] [PubMed] [Google Scholar]
  82. Kvaløy S., Godal T., Marton P. F., Steen H., Brenhovd I. O., Abrahamsen A. F. Spontaneous (H)-thymidine uptake in histological subgroups of human B-cell lymphomas. Scand J Haematol. 1981 Mar;26(3):221–234. doi: 10.1111/j.1600-0609.1981.tb01650.x. [DOI] [PubMed] [Google Scholar]
  83. Kvaløy S., Marton P. F., Kaalhus O., Høie J., Foss-Abrahamsen A., Godal T. 3H-thymidine uptake in B cell lymphomas--relationship to treatment response and survival. Scand J Haematol. 1985 May;34(5):429–435. doi: 10.1111/j.1600-0609.1985.tb00773.x. [DOI] [PubMed] [Google Scholar]
  84. Lalor P. A., Mapp P. I., Hall P. A., Revell P. A. Proliferative activity of cells in the synovium as demonstrated by a monoclonal antibody, Ki67. Rheumatol Int. 1987;7(5):183–186. doi: 10.1007/BF00541375. [DOI] [PubMed] [Google Scholar]
  85. Lee M. G., Nurse P. Complementation used to clone a human homologue of the fission yeast cell cycle control gene cdc2. Nature. 1987 May 7;327(6117):31–35. doi: 10.1038/327031a0. [DOI] [PubMed] [Google Scholar]
  86. Lehtinen T., Aine R., Lehtinen M., Kallioniemi O. P., Leino T., Hakala T., Leinikki P., Alavaikko M. Flow cytometric DNA analysis of 199 histologically favourable or unfavourable non-Hodgkin lymphomas. J Pathol. 1989 Jan;157(1):27–36. doi: 10.1002/path.1711570105. [DOI] [PubMed] [Google Scholar]
  87. Lischwe M. A., Smetana K., Olson M. O., Busch H. Proteins C23 and B23 are the major nucleolar silver staining proteins. Life Sci. 1979 Aug 20;25(8):701–708. doi: 10.1016/0024-3205(79)90512-5. [DOI] [PubMed] [Google Scholar]
  88. Lloyd R. V., Wilson B. S., Varani J., Gaur P. K., Moline S., Makari J. G. Immunocytochemical characterization of a monoclonal antibody that recognizes mitosing cells. Am J Pathol. 1985 Nov;121(2):275–283. [PMC free article] [PubMed] [Google Scholar]
  89. Lokhorst H. M., Boom S. E., Terpstra W., Roholl P., Gerdes J., Bast B. J. Determination of the growth fraction in monoclonal gammopathy with the monoclonal antibody Ki-67. Br J Haematol. 1988 Aug;69(4):477–481. doi: 10.1111/j.1365-2141.1988.tb02402.x. [DOI] [PubMed] [Google Scholar]
  90. Macartney J. C., Camplejohn R. S. DNA flow cytometry of histological material from dysplastic lesions of human gastric mucosa. J Pathol. 1986 Oct;150(2):113–118. doi: 10.1002/path.1711500205. [DOI] [PubMed] [Google Scholar]
  91. Mackillop W. J., Ciampi A., Till J. E., Buick R. N. A stem cell model of human tumor growth: implications for tumor cell clonogenic assays. J Natl Cancer Inst. 1983 Jan;70(1):9–16. [PubMed] [Google Scholar]
  92. Malaise E. P., Chavaudra N., Tubiana M. The relationship between growth rate, labelling index and histological type of human solid tumours. Eur J Cancer. 1973 Apr;9(4):305–312. doi: 10.1016/0014-2964(73)90099-6. [DOI] [PubMed] [Google Scholar]
  93. Masters J. R., Camplejohn R. S., Millis R. R., Rubens R. D. Histological grade, elastosis, DNA ploidy and the response to chemotherapy of breast cancer. Br J Cancer. 1987 Apr;55(4):455–457. doi: 10.1038/bjc.1987.89. [DOI] [PMC free article] [PubMed] [Google Scholar]
  94. Meyer J. S., Friedman E., McCrate M. M., Bauer W. C. Prediction of early course of breast carcinoma by thymidine labeling. Cancer. 1983 May 15;51(10):1879–1886. doi: 10.1002/1097-0142(19830515)51:10<1879::aid-cncr2820511021>3.0.co;2-9. [DOI] [PubMed] [Google Scholar]
  95. Meyer J. S., Prey M. U., Babcock D. S., McDivitt R. W. Breast carcinoma cell kinetics, morphology, stage, and host characteristics. A thymidine labeling study. Lab Invest. 1986 Jan;54(1):41–51. [PubMed] [Google Scholar]
  96. Miyachi K., Fritzler M. J., Tan E. M. Autoantibody to a nuclear antigen in proliferating cells. J Immunol. 1978 Dec;121(6):2228–2234. [PubMed] [Google Scholar]
  97. Morgan D. R., Williamson J. M., Quirke P., Clayden A. D., Smith M. E., O'Brien C. J., Allison D. L., Child J. A., Bird C. C. DNA content and prognosis of non-Hodgkin's lymphoma. Br J Cancer. 1986 Oct;54(4):643–649. doi: 10.1038/bjc.1986.221. [DOI] [PMC free article] [PubMed] [Google Scholar]
  98. Morgan D. W., Crocker J., Watts A., Shenoi P. M. Salivary gland tumours studied by means of the AgNOR technique. Histopathology. 1988 Nov;13(5):553–559. doi: 10.1111/j.1365-2559.1988.tb02079.x. [DOI] [PubMed] [Google Scholar]
  99. Morgan K. G., Quirke P., O'Brien C. J., Bird C. C. Hodgkin's disease: a flow cytometric study. J Clin Pathol. 1988 Apr;41(4):365–369. doi: 10.1136/jcp.41.4.365. [DOI] [PMC free article] [PubMed] [Google Scholar]
  100. Murray P. G., Boldy D. A., Crocker J., Ayres J. G. Sequential demonstration of antigens and AgNORs in frozen and paraffin sections. J Pathol. 1989 Oct;159(2):169–172. doi: 10.1002/path.1711590212. [DOI] [PubMed] [Google Scholar]
  101. Namikawa R., Suchi T., Ueda R., Itoh G., Koike K., Ota K., Takahashi T. Phenotyping of proliferating lymphocytes in angioimmunoblastic lymphadenopathy and related lesions by the double immunoenzymatic staining technique. Am J Pathol. 1987 May;127(2):279–287. [PMC free article] [PubMed] [Google Scholar]
  102. Namikawa R., Ueda R., Suchi T., Itoh G., Ota K., Takahashi T. Double immunoenzymatic detection of surface phenotype of proliferating lymphocytes in situ with monoclonal antibodies against DNA polymerase alpha and lymphocyte membrane antigens. Am J Clin Pathol. 1987 Jun;87(6):725–731. doi: 10.1093/ajcp/87.6.725. [DOI] [PubMed] [Google Scholar]
  103. Newton J. A., Camplejohn R. S., McGibbon D. H. The flow cytometry of melanocytic skin lesions. Br J Cancer. 1988 Nov;58(5):606–609. doi: 10.1038/bjc.1988.268. [DOI] [PMC free article] [PubMed] [Google Scholar]
  104. Norton L. Implications of kinetic heterogeneity in clinical oncology. Semin Oncol. 1985 Sep;12(3):231–249. [PubMed] [Google Scholar]
  105. O'Brien C. J., Holgate C., Quirke P., Stuart N. S., Ellis I. O., Elston C. W., Jones E. L., Bird C. C. Correlation of morphology, immunophenotype, and flow cytometry with remission induction and survival in high grade non-Hodgkin's lymphoma. J Pathol. 1989 May;158(1):31–39. doi: 10.1002/path.1711580108. [DOI] [PubMed] [Google Scholar]
  106. Ochs R. L., Busch H. Further evidence that phosphoprotein C23 (110 kD/pI 5.1) is the nucleolar silver staining protein. Exp Cell Res. 1984 May;152(1):260–265. doi: 10.1016/0014-4827(84)90251-9. [DOI] [PubMed] [Google Scholar]
  107. Olszewski W., Darzynkiewicz Z., Rosen P. P., Schwartz M. K., Melamed M. R. Flow cytometry of breast carcinoma: II. Relation of tumor cell cycle distribution to histology and estrogen receptor. Cancer. 1981 Aug 15;48(4):985–988. doi: 10.1002/1097-0142(19810815)48:4<985::aid-cncr2820480422>3.0.co;2-q. [DOI] [PubMed] [Google Scholar]
  108. Pace D., Morrison L., Bulmer J. N. Proliferative activity in endometrial stromal granulocytes throughout menstrual cycle and early pregnancy. J Clin Pathol. 1989 Jan;42(1):35–39. doi: 10.1136/jcp.42.1.35. [DOI] [PMC free article] [PubMed] [Google Scholar]
  109. Pileri S., Gerdes J., Rivano M., Tazzari P. L., Magnani M., Gobbi M., Stein H. Immunohistochemical determination of growth fractions in human permanent cell lines and lymphoid tumours: a critical comparison of the monoclonal antibodies OKT9 and Ki-67. Br J Haematol. 1987 Mar;65(3):271–276. doi: 10.1111/j.1365-2141.1987.tb06853.x. [DOI] [PubMed] [Google Scholar]
  110. Prelich G., Tan C. K., Kostura M., Mathews M. B., So A. G., Downey K. M., Stillman B. Functional identity of proliferating cell nuclear antigen and a DNA polymerase-delta auxiliary protein. Nature. 1987 Apr 2;326(6112):517–520. doi: 10.1038/326517a0. [DOI] [PubMed] [Google Scholar]
  111. Quirke P., Dixon M. F., Clayden A. D., Durdey P., Dyson J. E., Williams N. S., Bird C. C. Prognostic significance of DNA aneuploidy and cell proliferation in rectal adenocarcinomas. J Pathol. 1987 Apr;151(4):285–291. doi: 10.1002/path.1711510408. [DOI] [PubMed] [Google Scholar]
  112. Quirke P., Dyson J. E. Flow cytometry: methodology and applications in pathology. J Pathol. 1986 Jun;149(2):79–87. doi: 10.1002/path.1711490202. [DOI] [PubMed] [Google Scholar]
  113. Raber M. N., Barlogie B., Latreille J., Bedrossian C., Fritsche H., Blumenschein G. Ploidy, proliferative activity and estrogen receptor content in human breast cancer. Cytometry. 1982 Jul;3(1):36–41. doi: 10.1002/cyto.990030109. [DOI] [PubMed] [Google Scholar]
  114. Riabowol K., Draetta G., Brizuela L., Vandre D., Beach D. The cdc2 kinase is a nuclear protein that is essential for mitosis in mammalian cells. Cell. 1989 May 5;57(3):393–401. doi: 10.1016/0092-8674(89)90914-8. [DOI] [PubMed] [Google Scholar]
  115. Riccardi A., Danova M., Dionigi P., Gaetani P., Cebrelli T., Butti G., Mazzini G., Wilson G. Cell kinetics in leukaemia and solid tumours studied with in vivo bromodeoxyuridine and flow cytometry. Br J Cancer. 1989 Jun;59(6):898–903. doi: 10.1038/bjc.1989.190. [DOI] [PMC free article] [PubMed] [Google Scholar]
  116. Rivano M. T., Falini B., Stein H., Canino S., Ciani C., Gerdes J., Ribacchi R., Gobbi M., Pileri S. Histiocytic necrotizing lymphadenitis without granulocytic infiltration (Kikuchi's lymphadenitis). Morphological and immunohistochemical study of eight cases. Histopathology. 1987 Oct;11(10):1013–1027. doi: 10.1111/j.1365-2559.1987.tb01842.x. [DOI] [PubMed] [Google Scholar]
  117. Ronan S. G., Han M. C., Das Gupta T. K. Histologic prognostic indicators in cutaneous malignant melanoma. Semin Oncol. 1988 Dec;15(6):558–565. [PubMed] [Google Scholar]
  118. Roos G., Dige U., Lenner P., Lindh J., Johansson H. Prognostic significance of DNA-analysis by flow cytometry in non-Hodgkin's lymphoma. Hematol Oncol. 1985 Oct-Dec;3(4):233–242. doi: 10.1002/hon.2900030403. [DOI] [PubMed] [Google Scholar]
  119. Rowlands D. C. Nucleolar organising regions in cervical intraepithelial neoplasia. J Clin Pathol. 1988 Nov;41(11):1200–1202. doi: 10.1136/jcp.41.11.1200. [DOI] [PMC free article] [PubMed] [Google Scholar]
  120. Sasaki K., Matsumura K., Tsuji T., Shinozaki F., Takahashi M. Relationship between labeling indices of Ki-67 and BrdUrd in human malignant tumors. Cancer. 1988 Sep 1;62(5):989–993. doi: 10.1002/1097-0142(19880901)62:5<989::aid-cncr2820620525>3.0.co;2-u. [DOI] [PubMed] [Google Scholar]
  121. Sasaki K., Murakami T., Kawasaki M., Takahashi M. The cell cycle associated change of the Ki-67 reactive nuclear antigen expression. J Cell Physiol. 1987 Dec;133(3):579–584. doi: 10.1002/jcp.1041330321. [DOI] [PubMed] [Google Scholar]
  122. Schrape S., Jones D. B., Wright D. H. A comparison of three methods for the determination of the growth fraction in non-Hodgkin's lymphoma. Br J Cancer. 1987 Mar;55(3):283–286. doi: 10.1038/bjc.1987.54. [DOI] [PMC free article] [PubMed] [Google Scholar]
  123. Schutte B., Reynders M. M., Bosman F. T., Blijham G. H. Flow cytometric determination of DNA ploidy level in nuclei isolated from paraffin-embedded tissue. Cytometry. 1985 Jan;6(1):26–30. doi: 10.1002/cyto.990060106. [DOI] [PubMed] [Google Scholar]
  124. Schwartz B. R., Pinkus G., Bacus S., Toder M., Weinberg D. S. Cell proliferation in non-Hodgkin's lymphomas. Digital image analysis of Ki-67 antibody staining. Am J Pathol. 1989 Feb;134(2):327–336. [PMC free article] [PubMed] [Google Scholar]
  125. Schümperli D. Cell-cycle regulation of histone gene expression. Cell. 1986 May 23;45(4):471–472. doi: 10.1016/0092-8674(86)90277-1. [DOI] [PubMed] [Google Scholar]
  126. Scully R. E. Editorial: Mitosis counting--I. Hum Pathol. 1976 Jul;7(4):481–482. doi: 10.1016/s0046-8177(76)80062-7. [DOI] [PubMed] [Google Scholar]
  127. Silverberg S. G. Reproducibility of the mitosis count in the histologic diagnosis of smooth muscle tumors of the uterus. Hum Pathol. 1976 Jul;7(4):451–454. doi: 10.1016/s0046-8177(76)80058-5. [DOI] [PubMed] [Google Scholar]
  128. Silvestrini R., Costa A., Veneroni S., Del Bino G., Persici P. Comparative analysis of different approaches to investigate cell kinetics. Cell Tissue Kinet. 1988 Mar;21(2):123–131. doi: 10.1111/j.1365-2184.1988.tb00778.x. [DOI] [PubMed] [Google Scholar]
  129. Silvestrini R., Piazza R., Riccardi A., Rilke F. Correlation of cell kinetic findings with morphology of non-Hodgkin's malignant lymphomas. J Natl Cancer Inst. 1977 Mar;58(3):499–504. doi: 10.1093/jnci/58.3.499. [DOI] [PubMed] [Google Scholar]
  130. Simanis V., Nurse P. Characterization of the fission yeast cdc10+ protein that is required for commitment to the cell cycle. J Cell Sci. 1989 Jan;92(Pt 1):51–56. doi: 10.1242/jcs.92.1.51. [DOI] [PubMed] [Google Scholar]
  131. Smetana K., Gyorkey F., Chan P. K., Tan E., Busch H. Proliferating cell nuclear antigen (PCNA) and human malignant tumor nucleolar antigens (HMTNA) in nucleoli of human hematological malignancies. Blut. 1983 Mar;46(3):133–141. doi: 10.1007/BF00320271. [DOI] [PubMed] [Google Scholar]
  132. Srigley J., Barlogie B., Butler J. J., Osborne B., Blick M., Johnston D., Kantarjian H., Reuben J., Batsakis J., Freireich E. J. Heterogeneity of non-Hodgkin's lymphoma probed by nucleic acid cytometry. Blood. 1985 May;65(5):1090–1096. [PubMed] [Google Scholar]
  133. Steel G. G. Cell loss as a factor in the growth rate of human tumours. Eur J Cancer. 1967 Nov;3(4):381–387. doi: 10.1016/0014-2964(67)90022-9. [DOI] [PubMed] [Google Scholar]
  134. Suzuka I., Daidoji H., Matsuoka M., Kadowaki K., Takasaki Y., Nakane P. K., Moriuchi T. Gene for proliferating-cell nuclear antigen (DNA polymerase delta auxiliary protein) is present in both mammalian and higher plant genomes. Proc Natl Acad Sci U S A. 1989 May;86(9):3189–3193. doi: 10.1073/pnas.86.9.3189. [DOI] [PMC free article] [PubMed] [Google Scholar]
  135. Takasaki Y., Deng J. S., Tan E. M. A nuclear antigen associated with cell proliferation and blast transformation. J Exp Med. 1981 Dec 1;154(6):1899–1909. doi: 10.1084/jem.154.6.1899. [DOI] [PMC free article] [PubMed] [Google Scholar]
  136. Tanaka S., Hu S. Z., Wang T. S., Korn D. Preparation and preliminary characterization of monoclonal antibodies against human DNA polymerase alpha. J Biol Chem. 1982 Jul 25;257(14):8386–8390. [PubMed] [Google Scholar]
  137. Tannock I. F. The relation between cell proliferation and the vascular system in a transplanted mouse mammary tumour. Br J Cancer. 1968 Jun;22(2):258–273. doi: 10.1038/bjc.1968.34. [DOI] [PMC free article] [PubMed] [Google Scholar]
  138. Thornton J. G., Wells M., Hume W. J. Flash labelling of S-phase cells in short-term organ culture of normal and pathological human endometrium using bromodeoxyuridine and tritiated thymidine. J Pathol. 1988 Apr;154(4):321–328. doi: 10.1002/path.1711540407. [DOI] [PubMed] [Google Scholar]
  139. Thornton J. G., Wells M., Hume W. J. Measurement of the S-phase duration in normal and abnormal human endometrium by in vitro double labelling with bromodeoxyuridine and tritiated thymidine. J Pathol. 1989 Feb;157(2):109–115. doi: 10.1002/path.1711570205. [DOI] [PubMed] [Google Scholar]
  140. Thorud E., Fosså S. D., Vaage S., Kaalhus O., Knudsen O. S., Børmer O., Shoaib M. C. Primary breast cancer. Flow cytometric DNA pattern in relation to clinical and histopathologic characteristics. Cancer. 1986 Feb 15;57(4):808–811. doi: 10.1002/1097-0142(19860215)57:4<808::aid-cncr2820570421>3.0.co;2-#. [DOI] [PubMed] [Google Scholar]
  141. Ueda T., Aozasa K., Tsujimoto M., Ohsawa M., Uchida A., Aoki Y., Ono K., Matsumoto K. Prognostic significance of Ki-67 reactivity in soft tissue sarcomas. Cancer. 1989 Apr 15;63(8):1607–1611. doi: 10.1002/1097-0142(19890415)63:8<1607::aid-cncr2820630827>3.0.co;2-1. [DOI] [PubMed] [Google Scholar]
  142. Untawale S., Blick M. Oncogene expression in adenocarcinomas of the colon and in colon tumor-derived cell lines. Anticancer Res. 1988 Jan-Feb;8(1):1–7. [PubMed] [Google Scholar]
  143. Veneroni S., Costa A., Motta R., Giardini R., Rilke F., Silvestrini R. Comparative analysis of [3H]-thymidine labelling index and monoclonal antibody Ki-67 in non-Hodgkin's lymphomas. Hematol Oncol. 1988 Jan-Mar;6(1):21–28. doi: 10.1002/hon.2900060105. [DOI] [PubMed] [Google Scholar]
  144. Verheijen R., Kuijpers H. J., Schlingemann R. O., Boehmer A. L., van Driel R., Brakenhoff G. J., Ramaekers F. C. Ki-67 detects a nuclear matrix-associated proliferation-related antigen. I. Intracellular localization during interphase. J Cell Sci. 1989 Jan;92(Pt 1):123–130. doi: 10.1242/jcs.92.1.123. [DOI] [PubMed] [Google Scholar]
  145. Verheijen R., Kuijpers H. J., van Driel R., Beck J. L., van Dierendonck J. H., Brakenhoff G. J., Ramaekers F. C. Ki-67 detects a nuclear matrix-associated proliferation-related antigen. II. Localization in mitotic cells and association with chromosomes. J Cell Sci. 1989 Apr;92(Pt 4):531–540. doi: 10.1242/jcs.92.4.531. [DOI] [PubMed] [Google Scholar]
  146. Wagner B. M. Left ventricular hypertrophy and sudden death. Hum Pathol. 1986 Jan;17(1):1–1. doi: 10.1016/s0046-8177(86)80148-4. [DOI] [PubMed] [Google Scholar]
  147. Wahl A. F., Geis A. M., Spain B. H., Wong S. W., Korn D., Wang T. S. Gene expression of human DNA polymerase alpha during cell proliferation and the cell cycle. Mol Cell Biol. 1988 Nov;8(11):5016–5025. doi: 10.1128/mcb.8.11.5016. [DOI] [PMC free article] [PubMed] [Google Scholar]
  148. Walker R. A., Camplejohn R. S. Comparison of monoclonal antibody Ki-67 reactivity with grade and DNA flow cytometry of breast carcinomas. Br J Cancer. 1988 Mar;57(3):281–283. doi: 10.1038/bjc.1988.60. [DOI] [PMC free article] [PubMed] [Google Scholar]
  149. Walker R. A., Camplejohn R. S. DNA flow cytometry of human breast carcinomas and its relationship to transferrin and epidermal growth factor receptors. J Pathol. 1986 Sep;150(1):37–42. doi: 10.1002/path.1711500107. [DOI] [PubMed] [Google Scholar]
  150. Walker R. A. The histopathological evaluation of nucleolar organizer region proteins. Histopathology. 1988 Feb;12(2):221–223. doi: 10.1111/j.1365-2559.1988.tb01932.x. [DOI] [PubMed] [Google Scholar]
  151. Wang E. Rapid disappearance of statin, a nonproliferating and senescent cell-specific protein, upon reentering the process of cell cycling. J Cell Biol. 1985 Nov;101(5 Pt 1):1695–1701. doi: 10.1083/jcb.101.5.1695. [DOI] [PMC free article] [PubMed] [Google Scholar]
  152. Wersto R. P., Herz F., Gallagher R. E., Koss L. G. Cell cycle-dependent reactivity with the monoclonal antibody Ki-67 during myeloid cell differentiation. Exp Cell Res. 1988 Nov;179(1):79–88. doi: 10.1016/0014-4827(88)90350-3. [DOI] [PubMed] [Google Scholar]
  153. Williams M. A., Kleinschmidt J. A., Krohne G., Franke W. W. Argyrophilic nuclear and nucleolar proteins of Xenopus laevis oocytes identified by gel electrophoresis. Exp Cell Res. 1982 Feb;137(2):341–351. doi: 10.1016/0014-4827(82)90035-0. [DOI] [PubMed] [Google Scholar]
  154. Wilson G. D., McNally N. J., Dische S., Saunders M. I., Des Rochers C., Lewis A. A., Bennett M. H. Measurement of cell kinetics in human tumours in vivo using bromodeoxyuridine incorporation and flow cytometry. Br J Cancer. 1988 Oct;58(4):423–431. doi: 10.1038/bjc.1988.234. [DOI] [PMC free article] [PubMed] [Google Scholar]
  155. Wyllie A. H. Apoptosis: cell death in tissue regulation. J Pathol. 1987 Dec;153(4):313–316. doi: 10.1002/path.1711530404. [DOI] [PubMed] [Google Scholar]
  156. Young G. A., Hedley D. W., Rugg C. A., Iland H. J. The prognostic significance of proliferative activity in poor histology non-Hodgkin's lymphoma: a flow cytometry study using archival material. Eur J Cancer Clin Oncol. 1987 Oct;23(10):1497–1504. doi: 10.1016/0277-5379(87)90092-7. [DOI] [PubMed] [Google Scholar]
  157. de Capoa A., Baldini A., Marlekaj P., Natoli C., Rocchi M., Archidiacono N., Cianfarani S., Spadoni G. L., Boscherini B. Hormone-modulated rRNA gene activity is visualized by selective staining of the NOs. Cell Biol Int Rep. 1985 Sep;9(9):791–796. doi: 10.1016/0309-1651(85)90097-9. [DOI] [PubMed] [Google Scholar]
  158. van Dierendonck J. H., Keijzer R., van de Velde C. J., Cornelisse C. J. Nuclear distribution of the Ki-67 antigen during the cell cycle: comparison with growth fraction in human breast cancer cells. Cancer Res. 1989 Jun 1;49(11):2999–3006. [PubMed] [Google Scholar]

Articles from Journal of Clinical Pathology are provided here courtesy of BMJ Publishing Group

RESOURCES