Abstract
Degenerative changes are encountered relatively frequently in uterine leiomyomas. Morphologic changes within leiomyomas, particularly necrosis and alterations in cellularity, have been described following treatment with gonadotrophin releasing hormone analogue, but the effects of this form of treatment on the morphology of the normal myometrium are less well documented. A case is reported of a 42 year old woman with a history of menorrhagia in whom a combination of degenerative and iatrogenic changes resulted in a histological appearance resembling diffuse leiomyomatosis.
Full text
PDF
Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Colgan T. J., Pendergast S., LeBlanc M. The histopathology of uterine leiomyomas following treatment with gonadotropin-releasing hormone analogues. Hum Pathol. 1993 Oct;24(10):1073–1077. doi: 10.1016/0046-8177(93)90186-k. [DOI] [PubMed] [Google Scholar]
- Friedman A. J., Barbieri R. L., Benacerraf B. R., Schiff I. Treatment of leiomyomata with intranasal or subcutaneous leuprolide, a gonadotropin-releasing hormone agonist. Fertil Steril. 1987 Oct;48(4):560–564. [PubMed] [Google Scholar]
- Friedman A. J. Vaginal hemorrhage associated with degenerating submucous leiomyomata during leuprolide acetate treatment. Fertil Steril. 1989 Jul;52(1):152–154. doi: 10.1016/s0015-0282(16)60806-3. [DOI] [PubMed] [Google Scholar]
- Rein M. S., Friedman A. J., Stuart J. M., MacLaughlin D. T. Fibroid and myometrial steroid receptors in women treated with gonadotropin-releasing hormone agonist leuprolide acetate. Fertil Steril. 1990 Jun;53(6):1018–1023. [PubMed] [Google Scholar]
- Upadhyaya N. B., Doody M. C., Googe P. B. Histopathological changes in leiomyomata treated with leuprolide acetate. Fertil Steril. 1990 Nov;54(5):811–814. doi: 10.1016/s0015-0282(16)53937-5. [DOI] [PubMed] [Google Scholar]