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. 1995 Apr;48(4):300–303. doi: 10.1136/jcp.48.4.300

Parathyroid hormone related protein in oral squamous cell carcinomas invading the mandible.

F P Dunne 1, S J Bowden 1, J S Brown 1, W A Ratcliffe 1, R M Browne 1
PMCID: PMC502544  PMID: 7615845

Abstract

AIM--To assess parathyroid hormone related protein (PTHrP) as a candidate biochemical marker of invasion of the mandible by oral squamous cell carcinoma. METHODS--Tumour PTHrP concentrations were quantitated by immunoassay, and PTHrP was detected by immunohistochemistry, in a cohort of 24 primary squamous cell carcinomas of the mandible. RESULTS--PTHrP was identified in all tumours examined, but no correlation was found between scores of the intensity and/or consistency of staining or tumour PTHrP concentrations and the histological classification of tumour invasion. CONCLUSION--Although PTHrP was present in all squamous tumours studied, there was no correlation between PTHrP expression and pattern of tumour invasion. However, tumour derived PTHrP may act locally to influence tumour growth and differentiation and resorption of bone.

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Selected References

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  1. Bowden S. J., Emly J. F., Hughes S. V., Powell G., Ahmed A., Whittle M. J., Ratcliffe J. G., Ratcliffe W. A. Parathyroid hormone-related protein in human term placenta and membranes. J Endocrinol. 1994 Aug;142(2):217–224. doi: 10.1677/joe.0.1420217. [DOI] [PubMed] [Google Scholar]
  2. Bowden S. J., Hughes S. V., Ratcliffe W. A. Molecular forms of parathyroid hormone-related protein in tumours and biological fluids. Clin Endocrinol (Oxf) 1993 Mar;38(3):287–294. doi: 10.1111/j.1365-2265.1993.tb01008.x. [DOI] [PubMed] [Google Scholar]
  3. Centrella M., Canalis E., McCarthy T. L., Stewart A. F., Orloff J. J., Insogna K. L. Parathyroid hormone-related protein modulates the effect of transforming growth factor-beta on deoxyribonucleic acid and collagen synthesis in fetal rat bone cells. Endocrinology. 1989 Jul;125(1):199–208. doi: 10.1210/endo-125-1-199. [DOI] [PubMed] [Google Scholar]
  4. Chan S. D., Strewler G. J., King K. L., Nissenson R. A. Expression of a parathyroid hormone-like protein and its receptor during differentiation of embryonal carcinoma cells. Mol Endocrinol. 1990 Apr;4(4):638–646. doi: 10.1210/mend-4-4-638. [DOI] [PubMed] [Google Scholar]
  5. Danks J. A., Ebeling P. R., Hayman J., Chou S. T., Moseley J. M., Dunlop J., Kemp B. E., Martin T. J. Parathyroid hormone-related protein: immunohistochemical localization in cancers and in normal skin. J Bone Miner Res. 1989 Apr;4(2):273–278. doi: 10.1002/jbmr.5650040221. [DOI] [PubMed] [Google Scholar]
  6. Dunne F. P., Lee S., Ratcliffe W. A., Hutchesson A. C., Bundred N. J., Heath D. A. Parathyroid hormone-related protein (PTHrP) gene expression in solid tumours associated with normocalcaemia and hypercalcaemia. J Pathol. 1993 Nov;171(3):215–221. doi: 10.1002/path.1711710310. [DOI] [PubMed] [Google Scholar]
  7. Dunne F. P., Rollason T., Ratcliffe W. A., Marshall T., Heath D. A. Parathyroid hormone-related protein gene expression in invasive cervical tumors. Cancer. 1994 Jul 1;74(1):83–89. doi: 10.1002/1097-0142(19940701)74:1<83::aid-cncr2820740115>3.0.co;2-w. [DOI] [PubMed] [Google Scholar]
  8. Henderson J., Sebag M., Rhim J., Goltzman D., Kremer R. Dysregulation of parathyroid hormone-like peptide expression and secretion in a keratinocyte model of tumor progression. Cancer Res. 1991 Dec 15;51(24):6521–6528. [PubMed] [Google Scholar]
  9. Insogna K. L., Stewart A. F., Morris C. A., Hough L. M., Milstone L. M., Centrella M. Native and a synthetic analogue of the malignancy-associated parathyroid hormone-like protein have in vitro transforming growth factor-like properties. J Clin Invest. 1989 Mar;83(3):1057–1060. doi: 10.1172/JCI113947. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Jüppner H., Abou-Samra A. B., Uneno S., Gu W. X., Potts J. T., Jr, Segre G. V. The parathyroid hormone-like peptide associated with humoral hypercalcemia of malignancy and parathyroid hormone bind to the same receptor on the plasma membrane of ROS 17/2.8 cells. J Biol Chem. 1988 Jun 25;263(18):8557–8560. [PubMed] [Google Scholar]
  11. Kaiser S. M., Laneuville P., Bernier S. M., Rhim J. S., Kremer R., Goltzman D. Enhanced growth of a human keratinocyte cell line induced by antisense RNA for parathyroid hormone-related peptide. J Biol Chem. 1992 Jul 5;267(19):13623–13628. [PubMed] [Google Scholar]
  12. Kitazawa S., Kitazawa R., Fukase M., Fujimori T., Maeda S. Immunohistochemical evaluation of parathyroid hormone-related protein (PTHrP) in the uterine cervix. Int J Cancer. 1992 Mar 12;50(5):731–735. doi: 10.1002/ijc.2910500511. [DOI] [PubMed] [Google Scholar]
  13. Löwik C. W., Hoekman K., Offringa R., Groot C. G., Hendy G. N., Papapoulos S. E., Ponec M. Regulation of parathyroid hormonelike protein production in cultured normal and malignant keratinocytes. J Invest Dermatol. 1992 Feb;98(2):198–203. doi: 10.1111/1523-1747.ep12555864. [DOI] [PubMed] [Google Scholar]
  14. Mangin M., Webb A. C., Dreyer B. E., Posillico J. T., Ikeda K., Weir E. C., Stewart A. F., Bander N. H., Milstone L., Barton D. E. Identification of a cDNA encoding a parathyroid hormone-like peptide from a human tumor associated with humoral hypercalcemia of malignancy. Proc Natl Acad Sci U S A. 1988 Jan;85(2):597–601. doi: 10.1073/pnas.85.2.597. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. McGregor A. D., MacDonald D. G. Reactive changes in the mandible in the presence of squamous cell carcinoma. Head Neck Surg. 1988 Jul-Aug;10(6):378–386. doi: 10.1002/hed.2890100604. [DOI] [PubMed] [Google Scholar]
  16. Orloff J. J., Ganz M. B., Ribaudo A. E., Burtis W. J., Reiss M., Milstone L. M., Stewart A. F. Analysis of PTHRP binding and signal transduction mechanisms in benign and malignant squamous cells. Am J Physiol. 1992 May;262(5 Pt 1):E599–E607. doi: 10.1152/ajpendo.1992.262.5.E599. [DOI] [PubMed] [Google Scholar]
  17. Orloff J. J., Reddy D., de Papp A. E., Yang K. H., Soifer N. E., Stewart A. F. Parathyroid hormone-related protein as a prohormone: posttranslational processing and receptor interactions. Endocr Rev. 1994 Feb;15(1):40–60. doi: 10.1210/edrv-15-1-40. [DOI] [PubMed] [Google Scholar]
  18. Powell G. J., Southby J., Danks J. A., Stillwell R. G., Hayman J. A., Henderson M. A., Bennett R. C., Martin T. J. Localization of parathyroid hormone-related protein in breast cancer metastases: increased incidence in bone compared with other sites. Cancer Res. 1991 Jun 1;51(11):3059–3061. [PubMed] [Google Scholar]
  19. Ralston S. H., Danks J., Hayman J., Fraser W. D., Stewart C. S., Martin T. J. Parathyroid hormone-related protein of malignancy: immunohistochemical and biochemical studies in normocalcaemic and hypercalcaemic patients with cancer. J Clin Pathol. 1991 Jun;44(6):472–476. doi: 10.1136/jcp.44.6.472. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Ratcliffe W. A., Bowden S. J., Dunne F. P., Hughes S., Emly J. F., Baker J. T., Pye J. K., Williams C. P. Expression and processing of parathyroid hormone-related protein in a pancreatic endocrine cell tumour associated with hypercalcaemia. Clin Endocrinol (Oxf) 1994 May;40(5):679–686. doi: 10.1111/j.1365-2265.1994.tb03021.x. [DOI] [PubMed] [Google Scholar]
  21. Ratcliffe W. A., Norbury S., Heath D. A., Ratcliffe J. G. Development and validation of an immunoradiometric assay of parathyrin-related protein in unextracted plasma. Clin Chem. 1991 May;37(5):678–685. [PubMed] [Google Scholar]
  22. Schwartz S., Shklar G. Reaction of alveolar bone to invasion of oral carcinoma. Oral Surg Oral Med Oral Pathol. 1967 Jul;24(1):33–37. doi: 10.1016/0030-4220(67)90285-x. [DOI] [PubMed] [Google Scholar]
  23. Slootweg P. J., Müller H. Mandibular invasion by oral squamous cell carcinoma. J Craniomaxillofac Surg. 1989 Feb;17(2):69–74. doi: 10.1016/s1010-5182(89)80048-4. [DOI] [PubMed] [Google Scholar]
  24. Suva L. J., Mather K. A., Gillespie M. T., Webb G. C., Ng K. W., Winslow G. A., Wood W. I., Martin T. J., Hudson P. J. Structure of the 5' flanking region of the gene encoding human parathyroid-hormone-related protein (PTHrP). Gene. 1989 Apr 15;77(1):95–105. doi: 10.1016/0378-1119(89)90363-6. [DOI] [PubMed] [Google Scholar]
  25. Suva L. J., Winslow G. A., Wettenhall R. E., Hammonds R. G., Moseley J. M., Diefenbach-Jagger H., Rodda C. P., Kemp B. E., Rodriguez H., Chen E. Y. A parathyroid hormone-related protein implicated in malignant hypercalcemia: cloning and expression. Science. 1987 Aug 21;237(4817):893–896. doi: 10.1126/science.3616618. [DOI] [PubMed] [Google Scholar]

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