Abstract
AIMS--To propose a computerised image analysis based method for measuring, on paper mounted lung sections, the area macroscopically occupied by emphysema. METHODS--The study was based on the assessment of 69 lung sections prepared following a modified Gough-Wentworth technique. The results obtained from image analysis, point counting, and panel grading methods were compared, as was the repeatability of image analysis and panel grading. RESULTS--The results from image analysis and from point counting were not significantly different (p = 0.609) and significant quadratic regressions (r = 0.96, p < 0.001) were found between measurements from image analysis and from panel grading, the computerised technique being shown to be the most reproducible. CONCLUSIONS--Image analysis is a valuable and reproducible method to measure the area of lung macroscopically involved by emphysema.
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Selected References
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- Archer D. C., Coblentz C. L., deKemp R. A., Nahmias C., Norman G. Automated in vivo quantification of emphysema. Radiology. 1993 Sep;188(3):835–838. doi: 10.1148/radiology.188.3.8351358. [DOI] [PubMed] [Google Scholar]
- Bland J. M., Altman D. G. Statistical methods for assessing agreement between two methods of clinical measurement. Lancet. 1986 Feb 8;1(8476):307–310. [PubMed] [Google Scholar]
- Gevenois P. A., Koob M. C., Jacobovitz D., De Vuyst P., Yernault J. C., Struyven J. Whole lung sections for computed tomographic-pathologic correlations. Modified Gough-Wentworth technique. Invest Radiol. 1993 Mar;28(3):242–246. doi: 10.1097/00004424-199303000-00012. [DOI] [PubMed] [Google Scholar]
- Kalender W. A., Fichte H., Bautz W., Skalej M. Semiautomatic evaluation procedures for quantitative CT of the lung. J Comput Assist Tomogr. 1991 Mar-Apr;15(2):248–255. doi: 10.1097/00004728-199103000-00011. [DOI] [PubMed] [Google Scholar]
- Thurlbeck W. M., Dunnill M. S., Hartung W., Heard B. E., Heppleston A. G., Ryder R. C. A comparison of three methods of measuring emphysema. Hum Pathol. 1970 Jun;1(2):215–226. doi: 10.1016/s0046-8177(70)80035-1. [DOI] [PubMed] [Google Scholar]
- Turner P., Whimster W. F. Volume of emphysema. Thorax. 1981 Dec;36(12):932–937. doi: 10.1136/thx.36.12.932. [DOI] [PMC free article] [PubMed] [Google Scholar]