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. 1995 Apr;48(4):325–329. doi: 10.1136/jcp.48.4.325

The prevalence of lymphoid follicles in Helicobacter pylori associated gastritis in patients with ulcers and non-ulcer dyspepsia.

A M Zaitoun 1
PMCID: PMC502550  PMID: 7615851

Abstract

AIMS--To determine the prevalence of lymphoid follicles in Helicobacter pylori positive and negative gastritis in antral and body type gastric mucosa in patients with non-ulcer dyspepsia (NUD), duodenal ulcer, or gastric ulcer; to correlate follicle presence with patient age; to evaluate the correlation between the prevalence of lymphoid follicles and active and inactive gastritis and its severity; and to assess the positive predictive value of lymphoid follicle prevalence with respect to H pylori infection. METHODS--Gastric biopsy specimens, graded according to the Sydney system, from 337 patients were studied. RESULTS--Lymphoid follicles occurred more often in antral mucosa (78%) than in body type mucosa (41%) and were observed in 85% of patients with H pylori positive gastritis. There was no significant difference between NUD and gastric and duodenal ulcer disease with regard to the presence of lymphoid follicles. The positive predictive value of the presence of lymphoid follicles in H pylori infection was 96%. Lymphoid follicles were more commonly observed in patients aged between 10 and 29 years. Lymphoid follicles were more frequently found in pangastritis of all subtypes than in antral gastritis and also in active gastritis than in inactive gastritis. The presence of lymphoid follicles correlated strongly with the degree and severity of gastritis. CONCLUSION--Lymphoid follicles are a constant morphological feature of H pylori associated gastritis.

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Selected References

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  1. Conti-Nibali S., Sferlazzas C., Fera M. T., Saitta G., Tedeschi A., Magazzù G. Helicobacter pylori infection: a simplified diagnostic approach. Am J Gastroenterol. 1990 Dec;85(12):1573–1575. [PubMed] [Google Scholar]
  2. De Giacomo C., Fiocca R., Villani L., Lisato L., Licardi G., Diegoli N., Donadini A., Maggiore G. Helicobacter pylori infection and chronic gastritis: clinical, serological, and histologic correlations in children treated with amoxicillin and colloidal bismuth subcitrate. J Pediatr Gastroenterol Nutr. 1990 Oct;11(3):310–316. [PubMed] [Google Scholar]
  3. Eidt S., Stolte M. Prevalence of lymphoid follicles and aggregates in Helicobacter pylori gastritis in antral and body mucosa. J Clin Pathol. 1993 Sep;46(9):832–835. doi: 10.1136/jcp.46.9.832. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Genta R. M., Hamner H. W., Graham D. Y. Gastric lymphoid follicles in Helicobacter pylori infection: frequency, distribution, and response to triple therapy. Hum Pathol. 1993 Jun;24(6):577–583. doi: 10.1016/0046-8177(93)90235-9. [DOI] [PubMed] [Google Scholar]
  5. Hauke C., Grabner W., Grosse M., Stolte M. Zur Frage der Lymphfollikelbildung und der Entstehung der intestinalen Metaplasie in der Antrumschleimhaut als Reaktion auf eine Helicobacter pylori-Infektion. Leber Magen Darm. 1991 Jun;21(4):156–160. [PubMed] [Google Scholar]
  6. Karnes W. E., Jr, Samloff I. M., Siurala M., Kekki M., Sipponen P., Kim S. W., Walsh J. H. Positive serum antibody and negative tissue staining for Helicobacter pylori in subjects with atrophic body gastritis. Gastroenterology. 1991 Jul;101(1):167–174. doi: 10.1016/0016-5085(91)90474-y. [DOI] [PubMed] [Google Scholar]
  7. Price A. B. The Sydney System: histological division. J Gastroenterol Hepatol. 1991 May-Jun;6(3):209–222. doi: 10.1111/j.1440-1746.1991.tb01468.x. [DOI] [PubMed] [Google Scholar]
  8. Radin M. J., Eaton K. A., Krakowka S., Morgan D. R., Lee A., Otto G., Fox J. Helicobacter pylori gastric infection in gnotobiotic beagle dogs. Infect Immun. 1990 Aug;58(8):2606–2612. doi: 10.1128/iai.58.8.2606-2612.1990. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Stolte M., Eidt S. Lymphoid follicles in antral mucosa: immune response to Campylobacter pylori? J Clin Pathol. 1989 Dec;42(12):1269–1271. doi: 10.1136/jcp.42.12.1269. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Stolte M., Heilmann K. L. Neue Klassifikation und Graduierung der Gastritis. Leber Magen Darm. 1989 Sep;19(5):220–226. [PubMed] [Google Scholar]
  11. Wotherspoon A. C., Ortiz-Hidalgo C., Falzon M. R., Isaacson P. G. Helicobacter pylori-associated gastritis and primary B-cell gastric lymphoma. Lancet. 1991 Nov 9;338(8776):1175–1176. doi: 10.1016/0140-6736(91)92035-z. [DOI] [PubMed] [Google Scholar]
  12. Wyatt J. I., Rathbone B. J. Immune response of the gastric mucosa to Campylobacter pylori. Scand J Gastroenterol Suppl. 1988;142:44–49. [PubMed] [Google Scholar]
  13. Zaitoun A. M. Histological study of chronic gastritis from the United Arab Emirates using the Sydney system of classification. J Clin Pathol. 1994 Sep;47(9):810–815. doi: 10.1136/jcp.47.9.810. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Zaitoun A. M. Use of Romanowsky type (Diff-3) stain for detecting Helicobacter pylori in smears and tissue sections. J Clin Pathol. 1992 May;45(5):448–449. doi: 10.1136/jcp.45.5.448. [DOI] [PMC free article] [PubMed] [Google Scholar]

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