Abstract
AIMS--The effects on fetal growth of hyperlipidaemia in pregnancy are not well understood at present. In this study the different lipid fractions in normal pregnancies and pregnancies complicated by intrauterine growth retardation (IUGR) were determined and related to changes in plasma and serum viscosity. METHODS--Two groups of pregnant women were studied. Group 1 consisted of 35 healthy pregnant women aged between 21 and 38 years with no previous pathology and a normal pregnancy to term. Group 1 patients were studied at four periods defined at the start of the study: (1) < or = 17 weeks; (2) 18-24 weeks; (3) 25-32 weeks, (4) > or = 33 weeks. Group 2 consisted of 24 pregnant women aged between 16 and 34 years with ultrasound diagnosed IUGR confirmed after birth. Plasma lipids and plasma and serum viscosity were measured. RESULTS--Plasma triglycerides, low density lipoprotein cholesterol, and total cholesterol increased progressively throughout pregnancy, with significantly higher values after week 25. Apolipoprotein A (ApoA) and triglyceride concentrations were significantly lower in the IUGR group than in the normal group. The HDL/ApoA ratio was greater in the IUGR group than in the control group, as was the ApoB/ApoA ratio. There were no differences in the other lipids. Plasma and serum viscosity was higher in the IUGR group than in the normal group. CONCLUSIONS--Haemorheological modifications in the IUGR group are partly secondary to changes in high density lipoprotein metabolism and the competitive inhibition of fibrinolysis by ApoB, which is increased in pregnancies with IUGR. Changes in ApoA, and more specifically in the ApoB/ApoA ratio, could be good markers for the early detection of IUGR.
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Selected References
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- Allain C. C., Poon L. S., Chan C. S., Richmond W., Fu P. C. Enzymatic determination of total serum cholesterol. Clin Chem. 1974 Apr;20(4):470–475. [PubMed] [Google Scholar]
- Brown D. F. Blood lipids and lipoproteins in atherogenesis. Am J Med. 1969 May;46(5):691–704. doi: 10.1016/0002-9343(69)90021-7. [DOI] [PubMed] [Google Scholar]
- Darmady J. M., Postle A. D. Lipid metabolism in pregnancy. Br J Obstet Gynaecol. 1982 Mar;89(3):211–215. doi: 10.1111/j.1471-0528.1982.tb03616.x. [DOI] [PubMed] [Google Scholar]
- Ernst E., Resch K. L., Saradeth T., Maier A., Matrai A. A viscometric method of measuring plasma fibrinogen concentrations. J Clin Pathol. 1992 Jun;45(6):534–535. doi: 10.1136/jcp.45.6.534. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Fletcher A. P., Alkjaersig N. K., Burstein R. The influence of pregnancy upon blood coagulation and plasma fibrinolytic enzyme function. Am J Obstet Gynecol. 1979 Aug 1;134(7):743–751. doi: 10.1016/0002-9378(79)90940-2. [DOI] [PubMed] [Google Scholar]
- Friedewald W. T., Levy R. I., Fredrickson D. S. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem. 1972 Jun;18(6):499–502. [PubMed] [Google Scholar]
- Fåhraeus L., Larsson-Cohn U., Wallentin L. Plasma lipoproteins including high density lipoprotein subfractions during normal pregnancy. Obstet Gynecol. 1985 Oct;66(4):468–472. [PubMed] [Google Scholar]
- Hay W. W., Jr Energy and substrate requirements of the placenta and fetus. Proc Nutr Soc. 1991 Aug;50(2):321–336. doi: 10.1079/pns19910042. [DOI] [PubMed] [Google Scholar]
- Hillman L., Schonfeld G., Miller J. P., Wulff G. Apolipoproteins in human pregnancy. Metabolism. 1975 Aug;24(8):943–952. doi: 10.1016/0026-0495(75)90086-4. [DOI] [PubMed] [Google Scholar]
- Huisman A., Aarnoudse J. G., Heuvelmans J. H., Goslinga H., Fidler V., Huisjes H. J., Zijlstra W. G. Whole blood viscosity during normal pregnancy. Br J Obstet Gynaecol. 1987 Dec;94(12):1143–1149. doi: 10.1111/j.1471-0528.1987.tb02313.x. [DOI] [PubMed] [Google Scholar]
- Jimenez D. M., Pocovi M., Ramon-Cajal J., Romero M. A., Martinez H., Grande F. Longitudinal study of plasma lipids and lipoprotein cholesterol in normal pregnancy and puerperium. Gynecol Obstet Invest. 1988;25(3):158–164. doi: 10.1159/000293765. [DOI] [PubMed] [Google Scholar]
- Koenig W., Hehr R., Ditschuneit H. H., Kuhn K., Ernst E., Rosenthal J., Hombach V. Lovastatin alters blood rheology in primary hyperlipoproteinemia: dependence on lipoprotein(a)? J Clin Pharmacol. 1992 Jun;32(6):539–545. doi: 10.1177/009127009203200609. [DOI] [PubMed] [Google Scholar]
- Lopes-Virella M. F., Stone P., Ellis S., Colwell J. A. Cholesterol determination in high-density lipoproteins separated by three different methods. Clin Chem. 1977 May;23(5):882–884. [PubMed] [Google Scholar]
- Piccaro M., Rastelli D., Lombardo F., Ferrazzani S., Bondoli A., Cagnetta G., Boninsegna A., Moneta E. Quadro reologico e bioumorale nella gravidanza normale e patologica. Minerva Ginecol. 1982 Mar;34(3):111–126. [PubMed] [Google Scholar]
- Pickart L. R., Creasy R. K., Thaler M. M. Hyperfibrinogenemia and polycythemia with intrauterine growth retardation in fetal lambs. Am J Obstet Gynecol. 1976 Feb 1;124(3):268–271. doi: 10.1016/0002-9378(76)90155-1. [DOI] [PubMed] [Google Scholar]
- Potter J. M., Nestel P. J. The hyperlipidemia of pregnancy in normal and complicated pregnancies. Am J Obstet Gynecol. 1979 Jan 15;133(2):165–170. doi: 10.1016/0002-9378(79)90469-1. [DOI] [PubMed] [Google Scholar]
- Takayama M., Itoh S., Nagasaki T., Tanimizu I. A new enzymatic method for determination of serum choline-containing phospholipids. Clin Chim Acta. 1977 Aug 15;79(1):93–98. doi: 10.1016/0009-8981(77)90465-x. [DOI] [PubMed] [Google Scholar]
- Thomson A. M., Billewicz W. Z., Hytten F. E. The assessment of fetal growth. J Obstet Gynaecol Br Commonw. 1968 Sep;75(9):903–916. doi: 10.1111/j.1471-0528.1968.tb01615.x. [DOI] [PubMed] [Google Scholar]
- Thorburn J., Drummond M. M., Whigham K. A., Lowe G. D., Forbes C. D., Prentice C. R., Whitfield C. R. Blood viscosity and haemostatic factors in late pregnancy, pre-eclampsia and fetal growth retardation. Br J Obstet Gynaecol. 1982 Feb;89(2):117–122. doi: 10.1111/j.1471-0528.1982.tb04676.x. [DOI] [PubMed] [Google Scholar]
- Zondervan H. A., Oosting J., Hardeman M. R., Smorenberg-Schoorl M. E., Treffers P. E. The influence of maternal whole blood viscosity on fetal growth. Eur J Obstet Gynecol Reprod Biol. 1987 Jul;25(3):187–194. doi: 10.1016/0028-2243(87)90098-0. [DOI] [PubMed] [Google Scholar]