Abstract
This report describes the occurrence of splenic lymphoma with villous lymphocytes (SLVL) in a 56 year old white female with a family history of chronic lymphocytic leukaemia. Other unusual features included a marked lymphocytosis with counts up to 224 x 10(9)/l and marked clumping of lymphocytes in EDTA anticoagulated blood. The neoplastic cells were CD19+, CD20+, CD22+, CD22+, IgM+, lambda+, kappa-, CD5-, and CD10-. The spleen had nodular infiltrates of B lymphocytes in the region of the white pulp with minimal red pulp involvement. Electron microscopy of peripheral blood lymphocytes revealed cells with polar cytoplasmic processes. This report underlines the need for detailed analysis, including morphology and immunophenotyping, for each patient with a small B cell lymphoproliferative disorder.
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- Bassan R., Neonato M. G., Abbate M., Motta T., Barbui T., Rambaldi A. Monoclonal lymphocytosis with villous lymphocytes: a chronic lymphoproliferative disease of CD11c+ B-cells. Leukemia. 1991 Sep;5(9):799–806. [PubMed] [Google Scholar]
- Conley C. L., Misiti J., Laster A. J. Genetic factors predisposing to chronic lymphocytic leukemia and to autoimmune disease. Medicine (Baltimore) 1980 Sep;59(5):323–334. doi: 10.1097/00005792-198009000-00001. [DOI] [PubMed] [Google Scholar]
- De Oliveira M. S., Jaffe E. S., Catovsky D. Leukaemic phase of mantle zone (intermediate) lymphoma: its characterisation in 11 cases. J Clin Pathol. 1989 Sep;42(9):962–972. doi: 10.1136/jcp.42.9.962. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Juneja S., Wolf M., McLennan R. Clumping of lymphoma cells in peripheral blood induced by EDTA. J Clin Pathol. 1992 Jun;45(6):538–540. doi: 10.1136/jcp.45.6.538. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Matutes E., Morilla R., Owusu-Ankomah K., Houlihan A., Catovsky D. The immunophenotype of splenic lymphoma with villous lymphocytes and its relevance to the differential diagnosis with other B-cell disorders. Blood. 1994 Mar 15;83(6):1558–1562. [PubMed] [Google Scholar]
- Melo J. V., Hegde U., Parreira A., Thompson I., Lampert I. A., Catovsky D. Splenic B cell lymphoma with circulating villous lymphocytes: differential diagnosis of B cell leukaemias with large spleens. J Clin Pathol. 1987 Jun;40(6):642–651. doi: 10.1136/jcp.40.6.642. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Mulligan S. P., Matutes E., Dearden C., Catovsky D. Splenic lymphoma with villous lymphocytes: natural history and response to therapy in 50 cases. Br J Haematol. 1991 Jun;78(2):206–209. doi: 10.1111/j.1365-2141.1991.tb04417.x. [DOI] [PubMed] [Google Scholar]
- Neiman R. S., Sullivan A. L., Jaffe R. Malignant lymphoma simulating leukemic reticuloendotheliosis: a clinicopathologic study of ten cases. Cancer. 1979 Jan;43(1):329–342. doi: 10.1002/1097-0142(197901)43:1<329::aid-cncr2820430148>3.0.co;2-2. [DOI] [PubMed] [Google Scholar]
- Oscier D. G., Matutes E., Gardiner A., Glide S., Mould S., Brito-Babapulle V., Ellis J., Catovsky D. Cytogenetic studies in splenic lymphoma with villous lymphocytes. Br J Haematol. 1993 Nov;85(3):487–491. doi: 10.1111/j.1365-2141.1993.tb03337.x. [DOI] [PubMed] [Google Scholar]
- Ribeiro I., Costa M. M., Fernandes B. A., Sousa I., Melo A., Parreira A., Uva L. S. Splenic lymphoma with villous lymphocytes in two sisters. J Clin Pathol. 1992 Dec;45(12):1111–1113. doi: 10.1136/jcp.45.12.1111. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Spriano P., Barosi G., Invernizzi R., Ippoliti G., Fortunato A., Rosso R., Magrini U. Splenomegalic immunocytoma with circulating hairy cells. Report of eight cases and revision of the literature. Haematologica. 1986 Jan-Feb;71(1):25–33. [PubMed] [Google Scholar]