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. Author manuscript; available in PMC: 2017 Nov 1.
Published in final edited form as: Neuropharmacology. 2016 Jun 3;110(Pt A):118–124. doi: 10.1016/j.neuropharm.2016.06.002

Fig. 1.

Fig. 1

Timeline of experimental manipulations. Ovariectomized female rats were injected with the cannabinoid type 1 receptor inverse agonist, AM251, or vehicle (veh) followed by estradiol (E) or oil, on days 1, 2, 5, and 6 (n = 14–19 per group). Cocaine (Coc) was injected on days 3–7 and locomotor activity was assessed on day of the first and fifth Coc injections (Test 1 and Test 5 respectively). 24 hrs after the final Coc injection a subset of females that were tested for behavior were sacrificed for DiI labeling.