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. Author manuscript; available in PMC: 2017 Nov 1.
Published in final edited form as: Neuropharmacology. 2016 Jun 3;110(Pt A):118–124. doi: 10.1016/j.neuropharm.2016.06.002

Fig. 2.

Fig. 2

The estradiol-mediated increase in cocaine-induced ambulations depends on type 1 cannabinoid receptors. In estradiol (E) treated females, ambulations (mean + SEM) were higher in response to the fifth cocaine (Coc) vs. first Coc injection (Test 5 vs. Test 1). This effect of estradiol was not observed when females were treated with the cannabinoid type 1 receptor inverse agonist, AM251, 30 min prior to estradiol. Oil or AM251 treatment alone did not affect Coc-induced ambulations. The number inside of each bar represents the number of animals per treatment condition. * p < 0.0125 Veh+E Test 1 vs Veh+E Test 5