Figure 4. Effect of sorafenib on cell inactivation after combined treatment.

HNSCC cells were treated with 10 μM sorafenib and 1 μM cisplatin for 2 h before cells were irradiated using different doses. Twenty-four hours later cells were re-plated and cell inactivation was measured by colony forming assay (delayed plating). A. Relative cell survival (transformed values) including the effect of cisplatin and cisplatin + sorafenib treatment alone (inlays). B. Non transformed values.