Table 6. Cumulative effect of the three interacting factors of miRNA SNP-PGC SNP-HP infection on the gastric disease risk.

No. of interacting genotypes	Total population
	Cases/controls	Pa	OR(95%CI)
let-7e rs8111742-PGC rs6458238-H. pylori on GC risk
0	38/81		1(ref)
1	247/445	0.444	1.18(0.78-1.79)
2	204/189	<0.001	2.31(1.50-3.57)
3	28/7	<0.001	8.63(3.45-21.56)
		P trend<0.001
miR-4795 rs1002765-PGC rs9471643-H. pylori on AG risk
0	99/188		1(ref)
1	328/467	0.043	1.34(1.10-1.77)
2	330/177	<0.001	3.57(2.63-4.84)
3	42/25	<0.001	3.51(2.00-6.17)
		P trend<0.001

Note:

^aadjusted by sex and age.